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    Ralgapb Ral GTPase activating protein, beta subunit (non-catalytic) [ Mus musculus (house mouse) ]

    Gene ID: 228850, updated on 23-May-2018

    Summary

    Official Symbol
    Ralgapbprovided by MGI
    Official Full Name
    Ral GTPase activating protein, beta subunit (non-catalytic)provided by MGI
    Primary source
    MGI:MGI:2444531
    See related
    Ensembl:ENSMUSG00000027652 Vega:OTTMUSG00000015940
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p170; AI507211; B230339M05Rik
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 10.3), whole brain E14.5 (RPKM 9.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ralgapb in Genome Data Viewer
    Location:
    2; 2 H1
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (158409828..158499253)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (158235589..158324989)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA host gene 17 Neighboring gene small nucleolar RNA host gene 11 Neighboring gene Rho GTPase activating protein 40 Neighboring gene adipogenin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1219, 9330195P16

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GTPase activator activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Ral protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    activation of GTPase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    activation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of exocyst localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ral GTPase-activating protein subunit beta
    Names
    ral GTPase-activating protein beta subunit

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291137.1NP_001278066.1  ral GTPase-activating protein subunit beta isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AI836674, AL663091, AL844513, CJ119771
      Consensus CDS
      CCDS71178.1
      UniProtKB/TrEMBL
      E9Q0J2
      Related
      ENSMUSP00000105111.2, OTTMUSP00000054345, ENSMUST00000109485.8, OTTMUST00000097056
      Conserved Domains (1) summary
      pfam10428
      Location:354427
      SOG2; RAM signalling pathway protein
    2. NM_001291138.1NP_001278067.1  ral GTPase-activating protein subunit beta isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AI836674, AL663091, AL844513, CJ119771
      Consensus CDS
      CCDS71179.1
      UniProtKB/TrEMBL
      A2ACC6
      Related
      ENSMUSP00000105112.2, OTTMUSP00000017002, ENSMUST00000109486.8, OTTMUST00000037869
      Conserved Domains (1) summary
      pfam10428
      Location:354427
      SOG2; RAM signalling pathway protein
    3. NM_001363006.1NP_001349935.1  ral GTPase-activating protein subunit beta isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AL663091, AL844513

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      158409828..158499253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239491.2XP_011237793.1  ral GTPase-activating protein subunit beta isoform X8

      Conserved Domains (1) summary
      pfam10428
      Location:354427
      SOG2; RAM signalling pathway protein
    2. XM_006499359.3XP_006499422.1  ral GTPase-activating protein subunit beta isoform X2

      Conserved Domains (1) summary
      pfam10428
      Location:354427
      SOG2; RAM signalling pathway protein
    3. XM_006499361.3XP_006499424.1  ral GTPase-activating protein subunit beta isoform X3

      Conserved Domains (1) summary
      pfam10428
      Location:354427
      SOG2; RAM signalling pathway protein
    4. XM_006499357.3XP_006499420.1  ral GTPase-activating protein subunit beta isoform X1

      See identical proteins and their annotated locations for XP_006499420.1

      Conserved Domains (1) summary
      pfam10428
      Location:354427
      SOG2; RAM signalling pathway protein
    5. XM_006499363.3XP_006499426.1  ral GTPase-activating protein subunit beta isoform X5

      Conserved Domains (1) summary
      pfam10428
      Location:354427
      SOG2; RAM signalling pathway protein
    6. XM_006499362.3XP_006499425.1  ral GTPase-activating protein subunit beta isoform X4

      Conserved Domains (1) summary
      pfam10428
      Location:354427
      SOG2; RAM signalling pathway protein
    7. XM_011239490.2XP_011237792.1  ral GTPase-activating protein subunit beta isoform X6

      UniProtKB/TrEMBL
      F8WHN4
      Related
      ENSMUSP00000048430.5, ENSMUST00000046274.11
      Conserved Domains (1) summary
      pfam10428
      Location:354427
      SOG2; RAM signalling pathway protein
    8. XM_006499358.1XP_006499421.1  ral GTPase-activating protein subunit beta isoform X1

      See identical proteins and their annotated locations for XP_006499421.1

      Conserved Domains (1) summary
      pfam10428
      Location:354427
      SOG2; RAM signalling pathway protein
    9. XM_017317875.1XP_017173364.1  ral GTPase-activating protein subunit beta isoform X5

      Conserved Domains (1) summary
      pfam10428
      Location:354427
      SOG2; RAM signalling pathway protein
    10. XM_017317885.1XP_017173374.1  ral GTPase-activating protein subunit beta isoform X7

      Related
      ENSMUSP00000116481.1, OTTMUSP00000017003, ENSMUST00000141497.1, OTTMUST00000037870

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177227.2: Suppressed sequence

      Description
      NM_177227.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    2. NM_177658.3: Suppressed sequence

      Description
      NM_177658.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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