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    Dlgap4 DLG associated protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 228836, updated on 5-Sep-2021

    Summary

    Official Symbol
    Dlgap4provided by MGI
    Official Full Name
    DLG associated protein 4provided by MGI
    Primary source
    MGI:MGI:2138865
    See related
    Ensembl:ENSMUSG00000061689
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S; DA; DAP4; WBP1; DAP-4; WBP16; Sapap4; SAPAP-4; AI225853; BC024558
    Summary
    This gene encodes a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. The encoded protein may play a role in synapse organization and neuronal signalling. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Mar 2013]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 22.1), CNS E18 (RPKM 21.6) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Dlgap4 in Genome Data Viewer
    Location:
    2; 2 H1
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (156455431..156606283)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (156613633..156764363)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (156486464..156590099)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene AAR2 splicing factor homolog Neighboring gene predicted gene 14169 Neighboring gene predicted gene 14172 Neighboring gene predicted gene, 52566 Neighboring gene RIKEN cDNA 4930405A21 gene Neighboring gene ribosomal protein L9 pseudogene Neighboring gene myosin, light polypeptide 9, regulatory

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0964, MGC37636, MGC117830

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of postsynaptic neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in signaling IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cholinergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic specialization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in postsynaptic specialization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic specialization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    disks large-associated protein 4
    Names
    PSD-95/SAP90-binding protein 4
    SAP90/PSD-95-associated protein 4
    WW domain-binding protein 16
    discs, large homolog-associated protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042487.1NP_001035952.1  disks large-associated protein 4 isoform b

      See identical proteins and their annotated locations for NP_001035952.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks several 5' coding exons, and initiates translation at an alternate start codon, compared to variant 1. It represents use of an alternate promoter. The encoded isoform (b) is shorter and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      BC058948, BC085475, CF725232
      Consensus CDS
      CCDS38299.1
      UniProtKB/Swiss-Prot
      B1AZP2
      Related
      ENSMUSP00000096749.6, ENSMUST00000099145.6
      Conserved Domains (1) summary
      pfam03359
      Location:121453
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    2. NM_001042488.2NP_001035953.1  disks large-associated protein 4 isoform c

      See identical proteins and their annotated locations for NP_001035953.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks several 5' coding exons, and initiates translation at a downstream in-frame start codon, compared to variant 1. It represents use of an alternate promoter. The encoded isoform (c) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AK150554, BC058948, BX004793, BY298512
      Consensus CDS
      CCDS38300.1
      UniProtKB/Swiss-Prot
      B1AZP2
      UniProtKB/TrEMBL
      E9PUF2, Q3UCF7
      Related
      ENSMUSP00000105194.3, ENSMUST00000109566.9
      Conserved Domains (1) summary
      pfam03359
      Location:1285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    3. NM_001277186.1NP_001264115.1  disks large-associated protein 4 isoform d

      See identical proteins and their annotated locations for NP_001264115.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an exon and contains an alternate in-frame exon, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
      Source sequence(s)
      BC058948, BX004793, BX571766, BY122638, CJ111046, CJ117510, CX210973
      Consensus CDS
      CCDS71171.1
      UniProtKB/Swiss-Prot
      B1AZP2
      Related
      ENSMUSP00000105195.4, ENSMUST00000109567.10
      Conserved Domains (1) summary
      pfam03359
      Location:647989
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    4. NM_001277187.1NP_001264116.1  disks large-associated protein 4 isoform e

      See identical proteins and their annotated locations for NP_001264116.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (e) is shorter than isoform a.
      Source sequence(s)
      BC058948, BX004793, BY122638, CJ111046, CJ117510, CX210973
      Consensus CDS
      CCDS71172.1
      UniProtKB/Swiss-Prot
      B1AZP2
      UniProtKB/TrEMBL
      B7ZNS2
      Related
      ENSMUSP00000105196.4, ENSMUST00000109568.10
      Conserved Domains (1) summary
      pfam03359
      Location:643975
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    5. NM_146128.6NP_666240.4  disks large-associated protein 4 isoform a

      See identical proteins and their annotated locations for NP_666240.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      BC058948, BX004793, BY122638, CJ111046, CJ117510, CX210973
      Consensus CDS
      CCDS16968.1
      UniProtKB/Swiss-Prot
      B1AZP2
      Related
      ENSMUSP00000126980.3, ENSMUST00000169464.9
      Conserved Domains (1) summary
      pfam03359
      Location:660992
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      156455431..156606283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161542.1XP_036017435.1  disks large-associated protein 4 isoform X1

      Conserved Domains (1) summary
      pfam03359
      Location:660992
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    2. XM_017317840.3XP_017173329.1  disks large-associated protein 4 isoform X4

      Conserved Domains (1) summary
      pfam03359
      Location:650917
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    3. XM_006499341.4XP_006499404.1  disks large-associated protein 4 isoform X3

      Conserved Domains (1) summary
      pfam03359
      Location:660920
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    4. XM_036161546.1XP_036017439.1  disks large-associated protein 4 isoform X2

      Conserved Domains (1) summary
      pfam03359
      Location:647989
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    5. XM_006499340.5XP_006499403.1  disks large-associated protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006499403.1

      UniProtKB/Swiss-Prot
      B1AZP2
      Conserved Domains (1) summary
      pfam03359
      Location:660992
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    6. XM_030250649.1XP_030106509.1  disks large-associated protein 4 isoform X9

      Conserved Domains (1) summary
      pfam03359
      Location:1285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    7. XM_036161568.1XP_036017461.1  disks large-associated protein 4 isoform X9

      Conserved Domains (1) summary
      pfam03359
      Location:1285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    8. XM_006499350.5XP_006499413.1  disks large-associated protein 4 isoform X9

      See identical proteins and their annotated locations for XP_006499413.1

      UniProtKB/TrEMBL
      E9PUF2
      Conserved Domains (1) summary
      pfam03359
      Location:1285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    9. XM_030250650.2XP_030106510.1  disks large-associated protein 4 isoform X9

      Conserved Domains (1) summary
      pfam03359
      Location:1285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    10. XM_006499343.5XP_006499406.1  disks large-associated protein 4 isoform X8

      See identical proteins and their annotated locations for XP_006499406.1

      Conserved Domains (1) summary
      pfam03359
      Location:17298
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    11. XM_006499348.5XP_006499411.1  disks large-associated protein 4 isoform X9

      See identical proteins and their annotated locations for XP_006499411.1

      UniProtKB/TrEMBL
      E9PUF2
      Conserved Domains (1) summary
      pfam03359
      Location:1285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    12. XM_017317843.2XP_017173332.1  disks large-associated protein 4 isoform X7

      Conserved Domains (1) summary
      pfam03359
      Location:111450
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    13. XM_017317848.2XP_017173337.1  disks large-associated protein 4 isoform X9

      UniProtKB/TrEMBL
      E9PUF2
      Conserved Domains (1) summary
      pfam03359
      Location:1285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    14. XM_036161580.1XP_036017473.1  disks large-associated protein 4 isoform X9

      Conserved Domains (1) summary
      pfam03359
      Location:1285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    15. XM_036161581.1XP_036017474.1  disks large-associated protein 4 isoform X9

      Conserved Domains (1) summary
      pfam03359
      Location:1285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    16. XM_036161571.1XP_036017464.1  disks large-associated protein 4 isoform X9

      Conserved Domains (1) summary
      pfam03359
      Location:1285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    17. XM_006499346.5XP_006499409.1  disks large-associated protein 4 isoform X8

      See identical proteins and their annotated locations for XP_006499409.1

      Conserved Domains (1) summary
      pfam03359
      Location:17298
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    18. XM_030250653.2XP_030106513.1  disks large-associated protein 4 isoform X9

      Conserved Domains (1) summary
      pfam03359
      Location:1285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    19. XM_006499349.3XP_006499412.1  disks large-associated protein 4 isoform X9

      See identical proteins and their annotated locations for XP_006499412.1

      UniProtKB/TrEMBL
      E9PUF2
      Conserved Domains (1) summary
      pfam03359
      Location:1285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    20. XM_030250652.2XP_030106512.1  disks large-associated protein 4 isoform X9

      Conserved Domains (1) summary
      pfam03359
      Location:1285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    21. XM_006499344.4XP_006499407.1  disks large-associated protein 4 isoform X8

      See identical proteins and their annotated locations for XP_006499407.1

      Conserved Domains (1) summary
      pfam03359
      Location:17298
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    22. XM_030250651.2XP_030106511.1  disks large-associated protein 4 isoform X9

      Conserved Domains (1) summary
      pfam03359
      Location:1285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    23. XM_036161559.1XP_036017452.1  disks large-associated protein 4 isoform X8

      Conserved Domains (1) summary
      pfam03359
      Location:17298
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    24. XM_036161553.1XP_036017446.1  disks large-associated protein 4 isoform X6

      Conserved Domains (1) summary
      pfam03359
      Location:149491
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    25. XM_006499342.5XP_006499405.1  disks large-associated protein 4 isoform X5

      Conserved Domains (1) summary
      pfam03359
      Location:162494
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    26. XM_006499345.5XP_006499408.1  disks large-associated protein 4 isoform X8

      See identical proteins and their annotated locations for XP_006499408.1

      Conserved Domains (1) summary
      pfam03359
      Location:17298
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    27. XM_017317850.3XP_017173339.1  disks large-associated protein 4 isoform X9

      UniProtKB/TrEMBL
      E9PUF2
      Conserved Domains (1) summary
      pfam03359
      Location:1285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein
    28. XM_036161569.1XP_036017462.1  disks large-associated protein 4 isoform X9

      Conserved Domains (1) summary
      pfam03359
      Location:1285
      GKAP; Guanylate-kinase-associated protein (GKAP) protein

    RNA

    1. XR_003952548.2 RNA Sequence

    2. XR_003952547.2 RNA Sequence

    3. XR_003952549.2 RNA Sequence

    4. XR_001782346.2 RNA Sequence

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