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    MORC2 MORC family CW-type zinc finger 2 [ Homo sapiens (human) ]

    Gene ID: 22880, updated on 11-Jun-2024

    Summary

    Official Symbol
    MORC2provided by HGNC
    Official Full Name
    MORC family CW-type zinc finger 2provided by HGNC
    Primary source
    HGNC:HGNC:23573
    See related
    Ensembl:ENSG00000133422 MIM:616661; AllianceGenome:HGNC:23573
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZCW3; CMT2Z; DIGFAN; ZCWCC1
    Summary
    This gene encodes a member of the Microrchidia (MORC) protein superfamily. The encoded protein is known to regulate the condensation of heterochromatin in response to DNA damage and play a role in repressing transcription. The protein has been found to regulate the activity of ATP citrate lyase via specific interaction with this enzyme in the cytosol of lipogenic breast cancer cells. The protein also plays a role in lipogenesis and adipocyte differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
    Expression
    Broad expression in testis (RPKM 20.8), ovary (RPKM 5.3) and 24 other tissues See more
    Orthologs
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    Genomic context

    See MORC2 in Genome Data Viewer
    Location:
    22q12.2
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (30925130..30968774, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (31388696..31432332, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (31321117..31364760, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:31268713-31269213 Neighboring gene uncharacterized LOC105372994 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:31273667-31274409 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:31274410-31275151 Neighboring gene origin of replication in OSBP2 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr22:31281999-31282696 Neighboring gene uncharacterized LOC107985544 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:31288977-31289552 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:31289553-31290128 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18846 Neighboring gene eukaryotic translation initiation factor 4H pseudogene 2 Neighboring gene MORC2 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:31335586-31335801 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18847 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13620 Neighboring gene MPRA-validated peak4481 silencer Neighboring gene taurine up-regulated 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:31439932-31440502 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:31440503-31441072 Neighboring gene RNA, 7SL, cytoplasmic 633, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    part_of heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ATPase MORC2
    Names
    zinc finger CW-type coiled-coil domain protein 1
    NP_001290185.1
    NP_001290186.1
    NP_055756.1
    XP_011528306.1
    XP_016884156.1
    XP_047297159.1
    XP_047297160.1
    XP_054181250.1
    XP_054181251.1
    XP_054181252.1
    XP_054181253.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046752.1 RefSeqGene

      Range
      4724..48368
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001303256.3NP_001290185.1  ATPase MORC2 isoform 1

      See identical proteins and their annotated locations for NP_001290185.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC004542, BC019257, BM683680, CD653611, DR000665
      Consensus CDS
      CCDS77668.1
      UniProtKB/Swiss-Prot
      B2RNB1, Q9UF28, Q9Y6V2, Q9Y6X9
      Related
      ENSP00000380763.2, ENST00000397641.8
      Conserved Domains (2) summary
      pfam07496
      Location:495542
      zf-CW; CW-type Zinc Finger
      pfam13589
      Location:29169
      HATPase_c_3; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
    2. NM_001303257.2NP_001290186.1  ATPase MORC2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate, in-frame splice junction in the 3' coding region, compared to variant 1. This difference results in a shorter isoform (2) compared to variant 1.
      Source sequence(s)
      AC004542, BC019257, BM683680, BU733868, CD653611, DR000665
      UniProtKB/Swiss-Prot
      Q9Y6X9
      Conserved Domains (2) summary
      pfam07496
      Location:495542
      zf-CW; CW-type Zinc Finger
      pfam13589
      Location:29169
      HATPase_c_3; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
    3. NM_014941.3NP_055756.1  ATPase MORC2 isoform 3

      See identical proteins and their annotated locations for NP_055756.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an additional exon which results in the use of an in-frame downstream start codon, compared to variant 1. This difference results in an isoform (3) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AB020659, AC004542, BC019257, BM683680, CD653611
      Consensus CDS
      CCDS33636.1
      UniProtKB/Swiss-Prot
      Q9Y6X9
      Related
      ENSP00000215862.4, ENST00000215862.8
      Conserved Domains (4) summary
      pfam07496
      Location:433480
      zf-CW; CW-type Zinc Finger
      cl00075
      Location:1107
      HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
      cl26464
      Location:558673
      Atrophin-1; Atrophin-1 family
      cl26511
      Location:223302
      Neuromodulin_N; Gap junction protein N-terminal region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      30925130..30968774 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017028667.3XP_016884156.1  ATPase MORC2 isoform X2

      Conserved Domains (4) summary
      PHA03247
      Location:625740
      PHA03247; large tegument protein UL36; Provisional
      cd16931
      Location:18140
      HATPase_MORC-like; Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains
      pfam07496
      Location:500547
      zf-CW; CW-type Zinc Finger
      pfam17942
      Location:244456
      Morc6_S5; Morc6 ribosomal protein S5 domain 2-like
    2. XM_011530004.3XP_011528306.1  ATPase MORC2 isoform X1

      Conserved Domains (4) summary
      PHA03247
      Location:625740
      PHA03247; large tegument protein UL36; Provisional
      cd16931
      Location:18140
      HATPase_MORC-like; Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains
      pfam07496
      Location:500547
      zf-CW; CW-type Zinc Finger
      pfam17942
      Location:244456
      Morc6_S5; Morc6 ribosomal protein S5 domain 2-like
    3. XM_047441203.1XP_047297159.1  ATPase MORC2 isoform X3

    4. XM_047441204.1XP_047297160.1  ATPase MORC2 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      31388696..31432332 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054325276.1XP_054181251.1  ATPase MORC2 isoform X2

    2. XM_054325275.1XP_054181250.1  ATPase MORC2 isoform X1

    3. XM_054325277.1XP_054181252.1  ATPase MORC2 isoform X3

    4. XM_054325278.1XP_054181253.1  ATPase MORC2 isoform X3