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    Psmf1 proteasome (prosome, macropain) inhibitor subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 228769, updated on 23-Jun-2021

    Summary

    Official Symbol
    Psmf1provided by MGI
    Official Full Name
    proteasome (prosome, macropain) inhibitor subunit 1provided by MGI
    Primary source
    MGI:MGI:1346072
    See related
    Ensembl:ENSMUSG00000032869
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PI; PI31; AW048666; BC012260
    Expression
    Broad expression in testis adult (RPKM 115.5), ovary adult (RPKM 10.6) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Psmf1 in Genome Data Viewer
    Location:
    2; 2 G3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (151557982..151586114, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (151716062..151744199, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (151541798..151567029, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RAD21-like (S. pombe) Neighboring gene transmembrane 74B, opposite strand Neighboring gene transmembrane protein 74B Neighboring gene RIKEN cDNA 4930556L07 gene Neighboring gene heterogeneous nuclear ribonucleoprotein H1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC18784

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables proteasome binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    proteasome inhibitor PI31 subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305244.1NP_001292173.1  proteasome inhibitor PI31 subunit isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, uses an alternate start codon, and lacks two exons in the 5' coding region compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK083431, AL928988, BE649179
      Conserved Domains (1) summary
      pfam08577
      Location:68134
      PI31_Prot_C; PI31 proteasome regulator
    2. NM_212446.2NP_997611.1  proteasome inhibitor PI31 subunit isoform 1

      See identical proteins and their annotated locations for NP_997611.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK053924, AK083431, BE649179
      Consensus CDS
      CCDS16872.1
      UniProtKB/Swiss-Prot
      Q8BHL8
      UniProtKB/TrEMBL
      A2AU35
      Related
      ENSMUSP00000041184.5, ENSMUST00000042452.11
      Conserved Domains (2) summary
      pfam08577
      Location:182248
      PI31_Prot_C; PI31 proteasome regulator
      pfam11566
      Location:11148
      PI31_Prot_N; PI31 proteasome regulator N-terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      151557982..151586114 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499306.5XP_006499369.1  proteasome inhibitor PI31 subunit isoform X1

      UniProtKB/TrEMBL
      A0A1S6GWI1
      Conserved Domains (2) summary
      pfam08577
      Location:193255
      PI31_Prot_C; PI31 proteasome regulator
      pfam11566
      Location:18155
      PI31_Prot_N; PI31 proteasome regulator N-terminal

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_144889.2: Suppressed sequence

      Description
      NM_144889.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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