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    Kif18a kinesin family member 18A [ Mus musculus (house mouse) ]

    Gene ID: 228421, updated on 9-Sep-2018

    Summary

    Official Symbol
    Kif18aprovided by MGI
    Official Full Name
    kinesin family member 18Aprovided by MGI
    Primary source
    MGI:MGI:2446977
    See related
    Ensembl:ENSMUSG00000027115 Vega:OTTMUSG00000015098
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    gcd2; AU024633; B130001M12Rik
    Expression
    Biased expression in liver E14 (RPKM 8.8), CNS E11.5 (RPKM 7.2) and 10 other tissues See more
    Orthologs

    Genomic context

    See Kif18a in Genome Data Viewer
    Location:
    2; 2 E3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (109280738..109341749)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (109120895..109181904)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39905 Neighboring gene hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit pseudogene Neighboring gene methyltransferase like 15 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene brain derived neurotrophic factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC27627

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP-dependent microtubule motor activity, plus-end-directed IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATP-dependent microtubule motor activity, plus-end-directed ISO
    Inferred from Sequence Orthology
    more info
     
    ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule plus-end binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    tubulin-dependent ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    male meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic metaphase plate congression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic metaphase plate congression ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    seminiferous tubule development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    caveola ISO
    Inferred from Sequence Orthology
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kinetochore microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic spindle astral microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic spindle midzone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    kinesin-like protein KIF18A
    Names
    N-8 kinesin
    kinesin superfamily protein 18A

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139303.1NP_647464.1  kinesin-like protein KIF18A

      See identical proteins and their annotated locations for NP_647464.1

      Status: PROVISIONAL

      Source sequence(s)
      BC016095
      Consensus CDS
      CCDS16507.1
      UniProtKB/Swiss-Prot
      Q91WD7
      Related
      ENSMUSP00000028527.7, OTTMUSP00000016071, ENSMUST00000028527.7, OTTMUST00000035832
      Conserved Domains (2) summary
      cd01370
      Location:11355
      KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup
      pfam00225
      Location:17355
      Kinesin; Kinesin motor domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      109280738..109341749
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499259.1XP_006499322.1  kinesin-like protein KIF18A isoform X1

      Conserved Domains (2) summary
      cd01370
      Location:11355
      KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup
      pfam00225
      Location:17355
      Kinesin; Kinesin motor domain
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