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    RASA3 RAS p21 protein activator 3 [ Homo sapiens (human) ]

    Gene ID: 22821, updated on 17-Jun-2024

    Summary

    Official Symbol
    RASA3provided by HGNC
    Official Full Name
    RAS p21 protein activator 3provided by HGNC
    Primary source
    HGNC:HGNC:20331
    See related
    Ensembl:ENSG00000185989 MIM:605182; AllianceGenome:HGNC:20331
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GAPIII; GAP1IP4BP
    Summary
    This gene encodes a protein that binds inositol 1,3,4,5-tetrakisphosphate and stimulates the GTPase activity of Ras p21. This protein functions as a negative regulator of the Ras signalling pathway. It is localized to the cell membrane via a pleckstrin homology (PH) domain in the C-terminal region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
    Expression
    Ubiquitous expression in fat (RPKM 14.2), lymph node (RPKM 12.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RASA3 in Genome Data Viewer
    Location:
    13q34
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (113977783..114132623, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (113188423..113340668, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (114747194..114898098, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 452 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:114616152-114617351 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114622697-114623581 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8045 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114638965-114639466 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114639467-114639966 Neighboring gene chromosome 13 open reading frame 46 Neighboring gene SWI/SNF complex interacting GAS6 enhancer non-coding RNA Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114748299-114748799 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114789740-114790579 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114796667-114797608 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:114801666-114802865 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114804717-114805611 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8046 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8047 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114813561-114814350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114812769-114813560 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114829337-114829856 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8048 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8049 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8050 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5555 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8052 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8053 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8054 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:114838566-114839765 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:114848666-114849865 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:114852049-114853248 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114875547-114876182 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:114876854-114877008 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr13:114878083-114878678 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:114878884-114880083 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114880307-114881171 Neighboring gene uncharacterized LOC124903221 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114882210-114883162 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114883163-114884114 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:114884948-114885289 Neighboring gene RASA3 intronic transcript 1 Neighboring gene uncharacterized LOC107987192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114892696-114893197 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114895306-114895935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8055 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8056 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114897194-114897821 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5557 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114900119-114900619 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114906114-114907109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8058 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8059 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114916272-114916772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114916773-114917273 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114927227-114928127 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114951001-114951592 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114952186-114952777 Neighboring gene CFAP97 domain containing 2 Neighboring gene Sharpr-MPRA regulatory region 1096 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:114993807-114994308 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8061 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5558 Neighboring gene microRNA 548ar Neighboring gene cell division cycle 16

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC46517, MGC47588

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables intracellularly gated calcium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    ras GTPase-activating protein 3
    Names
    GTPase activating protein III
    GTPase-activating protein 1 family, inositol 1,3,4,5-tetrakisphosphate-binding protein
    Ins(1,3,4,5)P4-binding protein
    ins P4-binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320821.2NP_001307750.1  ras GTPase-activating protein 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains two alternate exons in the 5' region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (2) has a much shorter N-terminus than isoform 1.
      Source sequence(s)
      AK128094, AL161774, BC047242, DA328760
      UniProtKB/Swiss-Prot
      Q14644
      Conserved Domains (3) summary
      smart00107
      Location:296331
      BTK; Bruton's tyrosine kinase Cys-rich motif
      cd13371
      Location:179303
      PH_GAP1_mammal-like; GAP1(IP4BP) pleckstrin homology (PH) domain
      cl02569
      Location:1182
      RasGAP; Ras GTPase Activating Domain
    2. NM_001320822.2NP_001307751.1  ras GTPase-activating protein 3 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AK294913, AL161774, BC047242
      UniProtKB/Swiss-Prot
      Q14644
      Conserved Domains (7) summary
      smart00107
      Location:647682
      BTK; Bruton's tyrosine kinase Cys-rich motif
      cd04010
      Location:114256
      C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
      cd08401
      Location:1101
      C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
      cd05134
      Location:265533
      RasGAP_RASA3; Ras-GTPase Activating Domain of RASA3
      smart00323
      Location:243582
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13371
      Location:530654
      PH_GAP1_mammal-like; GAP1(IP4BP) pleckstrin homology (PH) domain
      pfam00169
      Location:545644
      PH; PH domain
    3. NM_007368.4NP_031394.2  ras GTPase-activating protein 3 isoform 1

      See identical proteins and their annotated locations for NP_031394.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK128094, BC038456, BC047242, DA328760
      Consensus CDS
      CCDS32016.1
      UniProtKB/Swiss-Prot
      A6NL15, F8W6X8, Q14644, Q8IUY2
      Related
      ENSP00000335029.7, ENST00000334062.8
      Conserved Domains (5) summary
      smart00107
      Location:679714
      BTK; Bruton's tyrosine kinase Cys-rich motif
      cd04010
      Location:146288
      C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
      cd08401
      Location:13133
      C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
      cd05134
      Location:297565
      RasGAP_RASA3; Ras-GTPase Activating Domain of RASA3
      cd13371
      Location:562686
      PH_GAP1_mammal-like; GAP1(IP4BP) pleckstrin homology (PH) domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      113977783..114132623 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047430157.1XP_047286113.1  ras GTPase-activating protein 3 isoform X4

    2. XM_047430155.1XP_047286111.1  ras GTPase-activating protein 3 isoform X2

    3. XM_047430156.1XP_047286112.1  ras GTPase-activating protein 3 isoform X3

    4. XM_011534841.4XP_011533143.1  ras GTPase-activating protein 3 isoform X2

      See identical proteins and their annotated locations for XP_011533143.1

      UniProtKB/Swiss-Prot
      Q14644
      Conserved Domains (7) summary
      smart00107
      Location:647682
      BTK; Bruton's tyrosine kinase Cys-rich motif
      cd04010
      Location:114256
      C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
      cd08401
      Location:1101
      C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
      cd05134
      Location:265533
      RasGAP_RASA3; Ras-GTPase Activating Domain of RASA3
      smart00323
      Location:243582
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13371
      Location:530654
      PH_GAP1_mammal-like; GAP1(IP4BP) pleckstrin homology (PH) domain
      pfam00169
      Location:545644
      PH; PH domain
    5. XM_011534842.3XP_011533144.1  ras GTPase-activating protein 3 isoform X2

      See identical proteins and their annotated locations for XP_011533144.1

      UniProtKB/Swiss-Prot
      Q14644
      Conserved Domains (7) summary
      smart00107
      Location:647682
      BTK; Bruton's tyrosine kinase Cys-rich motif
      cd04010
      Location:114256
      C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
      cd08401
      Location:1101
      C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
      cd05134
      Location:265533
      RasGAP_RASA3; Ras-GTPase Activating Domain of RASA3
      smart00323
      Location:243582
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13371
      Location:530654
      PH_GAP1_mammal-like; GAP1(IP4BP) pleckstrin homology (PH) domain
      pfam00169
      Location:545644
      PH; PH domain
    6. XM_047430158.1XP_047286114.1  ras GTPase-activating protein 3 isoform X4

    7. XM_047430161.1XP_047286117.1  ras GTPase-activating protein 3 isoform X4

    8. XM_047430163.1XP_047286119.1  ras GTPase-activating protein 3 isoform X4

    9. XM_047430162.1XP_047286118.1  ras GTPase-activating protein 3 isoform X4

    10. XM_047430160.1XP_047286116.1  ras GTPase-activating protein 3 isoform X4

    11. XM_047430154.1XP_047286110.1  ras GTPase-activating protein 3 isoform X1

    12. XM_047430159.1XP_047286115.1  ras GTPase-activating protein 3 isoform X5

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_011332698.1 Reference GRCh38.p14 PATCHES

      Range
      40809..191714 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331721.1XP_054187696.1  ras GTPase-activating protein 3 isoform X4

    2. XM_054331718.1XP_054187693.1  ras GTPase-activating protein 3 isoform X2

    3. XM_054331719.1XP_054187694.1  ras GTPase-activating protein 3 isoform X3

    4. XM_054331717.1XP_054187692.1  ras GTPase-activating protein 3 isoform X2

    5. XM_054331720.1XP_054187695.1  ras GTPase-activating protein 3 isoform X2

    6. XM_054331722.1XP_054187697.1  ras GTPase-activating protein 3 isoform X4

    7. XM_054331726.1XP_054187701.1  ras GTPase-activating protein 3 isoform X4

    8. XM_054331725.1XP_054187700.1  ras GTPase-activating protein 3 isoform X4

    9. XM_054331724.1XP_054187699.1  ras GTPase-activating protein 3 isoform X4

    10. XM_054331716.1XP_054187691.1  ras GTPase-activating protein 3 isoform X1

    11. XM_054331723.1XP_054187698.1  ras GTPase-activating protein 3 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      113188423..113340668 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374237.1XP_054230212.1  ras GTPase-activating protein 3 isoform X4

    2. XM_054374234.1XP_054230209.1  ras GTPase-activating protein 3 isoform X2

    3. XM_054374235.1XP_054230210.1  ras GTPase-activating protein 3 isoform X7

    4. XM_054374233.1XP_054230208.1  ras GTPase-activating protein 3 isoform X2

    5. XM_054374236.1XP_054230211.1  ras GTPase-activating protein 3 isoform X2

    6. XM_054374238.1XP_054230213.1  ras GTPase-activating protein 3 isoform X4

    7. XM_054374240.1XP_054230215.1  ras GTPase-activating protein 3 isoform X4

    8. XM_054374242.1XP_054230217.1  ras GTPase-activating protein 3 isoform X4

    9. XM_054374241.1XP_054230216.1  ras GTPase-activating protein 3 isoform X4

    10. XM_054374232.1XP_054230207.1  ras GTPase-activating protein 3 isoform X6

    11. XM_054374239.1XP_054230214.1  ras GTPase-activating protein 3 isoform X5