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    MRAS muscle RAS oncogene homolog [ Homo sapiens (human) ]

    Gene ID: 22808, updated on 8-Jul-2021

    Summary

    Official Symbol
    MRASprovided by HGNC
    Official Full Name
    muscle RAS oncogene homologprovided by HGNC
    Primary source
    HGNC:HGNC:7227
    See related
    Ensembl:ENSG00000158186 MIM:608435
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NS11; M-RAs; RRAS3; R-RAS3
    Summary
    This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
    Expression
    Broad expression in fat (RPKM 37.4), heart (RPKM 23.2) and 16 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See MRAS in Genome Data Viewer
    Location:
    3q22.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (138347648..138405535)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (138066490..138124377)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene debranching RNA lariats 1 Neighboring gene armadillo repeat containing 8 Neighboring gene NME/NM23 family member 9 Neighboring gene uncharacterized LOC105374129 Neighboring gene extended synaptotagmin 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    GeneReviews: Not available
    Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
    GeneReviews: Not available
    Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
    GeneReviews: Not available
    New susceptibility locus for coronary artery disease on chromosome 3q22.3.
    GeneReviews: Not available
    Noonan syndrome 11
    MedGen: C5193130 OMIM: 618499 GeneReviews: Not available
    Compare labs
    Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
    GeneReviews: Not available

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ42964

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTP-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in Ras protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in actin cytoskeleton organization TAS
    Traceable Author Statement
    more info
     
    involved_in cellular response to leukemia inhibitory factor IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in multicellular organism development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in muscle organ development TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    ras-related protein M-Ras
    Names
    muscle and microspikes RAS
    ras-related protein R-Ras3
    NP_001078518.1
    NP_001239019.1
    NP_001239020.1
    NP_001239021.1
    NP_001239022.1
    NP_036351.3
    XP_005247285.1
    XP_005247286.1
    XP_016861376.1
    XP_024309164.1
    XP_024309165.1
    XP_024309166.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085049.3NP_001078518.1  ras-related protein M-Ras isoform 1 precursor

      See identical proteins and their annotated locations for NP_001078518.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC022337, AF022080, AK123833, AK316071, BC017733, BC047690, CN356600
      Consensus CDS
      CCDS3100.1
      UniProtKB/Swiss-Prot
      O14807
      UniProtKB/TrEMBL
      Q6FGP0, Q8WVM9
      Related
      ENSP00000389682.2, ENST00000423968.7
      Conserved Domains (1) summary
      cd04145
      Location:12176
      M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3
    2. NM_001252090.2NP_001239019.1  ras-related protein M-Ras isoform 1 precursor

      See identical proteins and their annotated locations for NP_001239019.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC022497, AF493918, AK123833, AK316071, BC017733, BI488489
      Consensus CDS
      CCDS3100.1
      UniProtKB/Swiss-Prot
      O14807
      UniProtKB/TrEMBL
      Q6FGP0, Q8WVM9
      Related
      ENSP00000418356.1, ENST00000474559.1
      Conserved Domains (1) summary
      cd04145
      Location:12176
      M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3
    3. NM_001252091.1NP_001239020.1  ras-related protein M-Ras isoform 2 precursor

      See identical proteins and their annotated locations for NP_001239020.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an exon and uses a downstream, in-frame start codon, compared to variant 1. Variants 4, 5 and 6 encode the same isoform (2), which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK123833, AK316071, BC017733, DA235195, DA355883
      Consensus CDS
      CCDS58855.1
      UniProtKB/Swiss-Prot
      O14807
      UniProtKB/TrEMBL
      Q8WVM9
      Related
      ENSP00000484586.1, ENST00000614350.4
      Conserved Domains (1) summary
      cl38936
      Location:1100
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    4. NM_001252092.2NP_001239021.1  ras-related protein M-Ras isoform 2 precursor

      See identical proteins and their annotated locations for NP_001239021.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks an exon and uses a downstream, in-frame start codon, compared to variant 1. Variants 4, 5 and 6 encode the same isoform (2), which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK123833, AK295640, BC017733
      Consensus CDS
      CCDS58855.1
      UniProtKB/Swiss-Prot
      O14807
      UniProtKB/TrEMBL
      Q8WVM9
      Related
      ENSP00000419582.1, ENST00000464896.5
      Conserved Domains (1) summary
      cl38936
      Location:1100
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    5. NM_001252093.2NP_001239022.1  ras-related protein M-Ras isoform 2 precursor

      See identical proteins and their annotated locations for NP_001239022.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks an exon and uses a downstream, in-frame start codon, compared to variant 1. Variants 4, 5 and 6 encode the same isoform (2), which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC022337, AI216578, AK123833, AK316071, BC017733, CN356600
      Consensus CDS
      CCDS58855.1
      UniProtKB/Swiss-Prot
      O14807
      UniProtKB/TrEMBL
      Q8WVM9
      Related
      ENSP00000481637.1, ENST00000621127.4
      Conserved Domains (1) summary
      cl38936
      Location:1100
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    6. NM_012219.4NP_036351.3  ras-related protein M-Ras isoform 1 precursor

      See identical proteins and their annotated locations for NP_036351.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AK123833, AK124954, BC017733, DA235195
      Consensus CDS
      CCDS3100.1
      UniProtKB/Swiss-Prot
      O14807
      UniProtKB/TrEMBL
      Q6FGP0, Q8WVM9
      Related
      ENSP00000289104.4, ENST00000289104.8
      Conserved Domains (1) summary
      cd04145
      Location:12176
      M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      138347648..138405535
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024453397.1XP_024309165.1  ras-related protein M-Ras isoform X2

      Conserved Domains (1) summary
      cl38936
      Location:12150
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. XM_005247229.2XP_005247286.1  ras-related protein M-Ras isoform X2

      See identical proteins and their annotated locations for XP_005247286.1

      Conserved Domains (1) summary
      cl38936
      Location:12150
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    3. XM_024453398.1XP_024309166.1  ras-related protein M-Ras isoform X2

      Conserved Domains (1) summary
      cl38936
      Location:12150
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    4. XM_005247228.1XP_005247285.1  ras-related protein M-Ras isoform X1

      See identical proteins and their annotated locations for XP_005247285.1

      UniProtKB/Swiss-Prot
      O14807
      UniProtKB/TrEMBL
      Q6FGP0
      Conserved Domains (1) summary
      cd04145
      Location:12176
      M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3
    5. XM_024453396.1XP_024309164.1  ras-related protein M-Ras isoform X1

      Conserved Domains (1) summary
      cd04145
      Location:12176
      M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3
    6. XM_017005887.2XP_016861376.1  ras-related protein M-Ras isoform X1

      UniProtKB/Swiss-Prot
      O14807
      UniProtKB/TrEMBL
      Q6FGP0
      Conserved Domains (1) summary
      cd04145
      Location:12176
      M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3
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