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    Sestd1 SEC14 and spectrin domains 1 [ Mus musculus (house mouse) ]

    Gene ID: 228071, updated on 5-Aug-2018

    Summary

    Official Symbol
    Sestd1provided by MGI
    Official Full Name
    SEC14 and spectrin domains 1provided by MGI
    Primary source
    MGI:MGI:1916262
    See related
    Ensembl:ENSMUSG00000042272 Vega:OTTMUSG00000013223
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A930010O20; Solo/Trio8; 1500031J16Rik
    Expression
    Broad expression in CNS E18 (RPKM 13.9), whole brain E14.5 (RPKM 12.9) and 21 other tissues See more
    Orthologs

    Genomic context

    See Sestd1 in Genome Data Viewer
    Location:
    2; 2 C3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (77180340..77280592, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (77024132..77083146, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 141 Neighboring gene predicted gene, 39862 Neighboring gene predicted gene, 39861 Neighboring gene nucleophosmin 1 pseudogene Neighboring gene predicted gene, 35266 Neighboring gene ubiquitin-conjugating enzyme E2 variant 2 pseudogene Neighboring gene phosphoribosyl pyrophosphate synthetase-associated protein 2 pseudogene Neighboring gene predicted gene, 35317

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC51459

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    phosphatidic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol-3,4-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol-3,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol-3-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol-4-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol-5-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    colocalizes_with calcium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    SEC14 domain and spectrin repeat-containing protein 1
    Names
    huntingtin-interacting protein-like protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175465.6NP_780674.1  SEC14 domain and spectrin repeat-containing protein 1

      See identical proteins and their annotated locations for NP_780674.1

      Status: VALIDATED

      Source sequence(s)
      AI848264, AL772242, BB647911, BG082832, CF175139, CN664477, CO425092
      Consensus CDS
      CCDS16163.1
      UniProtKB/Swiss-Prot
      Q80UK0
      Related
      ENSMUSP00000099720.1, OTTMUSP00000014233, ENSMUST00000102659.1, OTTMUST00000031970
      Conserved Domains (2) summary
      pfam13716
      Location:28147
      CRAL_TRIO_2; Divergent CRAL/TRIO domain
      cl02488
      Location:273478
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      77180340..77280592 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499202.3XP_006499265.1  SEC14 domain and spectrin repeat-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006499265.1

      UniProtKB/Swiss-Prot
      Q80UK0
      Related
      ENSMUSP00000099721.1, OTTMUSP00000014232, ENSMUST00000102660.7, OTTMUST00000031969
      Conserved Domains (2) summary
      pfam13716
      Location:28147
      CRAL_TRIO_2; Divergent CRAL/TRIO domain
      cl02488
      Location:273478
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    2. XM_006499201.2XP_006499264.1  SEC14 domain and spectrin repeat-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006499264.1

      UniProtKB/Swiss-Prot
      Q80UK0
      Conserved Domains (2) summary
      pfam13716
      Location:28147
      CRAL_TRIO_2; Divergent CRAL/TRIO domain
      cl02488
      Location:273478
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    3. XM_006499200.2XP_006499263.1  SEC14 domain and spectrin repeat-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006499263.1

      UniProtKB/Swiss-Prot
      Q80UK0
      Conserved Domains (2) summary
      pfam13716
      Location:28147
      CRAL_TRIO_2; Divergent CRAL/TRIO domain
      cl02488
      Location:273478
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    4. XM_011239447.1XP_011237749.1  SEC14 domain and spectrin repeat-containing protein 1 isoform X2

      Conserved Domains (2) summary
      cl02488
      Location:191396
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl15787
      Location:165
      SEC14; Sec14p-like lipid-binding domain. Found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to ...
    5. XM_017317597.1XP_017173086.1  SEC14 domain and spectrin repeat-containing protein 1 isoform X3

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