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    Atp5g3 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9) [ Mus musculus (house mouse) ]

    Gene ID: 228033, updated on 31-Jan-2019

    Summary

    Official Symbol
    Atp5g3provided by MGI
    Official Full Name
    ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)provided by MGI
    Primary source
    MGI:MGI:2442035
    See related
    Ensembl:ENSMUSG00000018770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Atp5mc3; 6030447M23
    Summary
    The protein encoded by this gene is a subunit of mitochondrial membrane ATP synthase, the enzyme that catalyzes ATP synthesis during oxidative phosphorylation. This gene encodes subunit 9, which is present in multiple copies in the transmembrane part of the ATP synthase complex. Phenotype and gene expression profiles suggest correlations between this gene and alcoholism- and obesity-related phenotypes. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Sep 2014]
    Expression
    Ubiquitous expression in heart adult (RPKM 896.5), kidney adult (RPKM 502.3) and 27 other tissues See more
    Orthologs

    Genomic context

    See Atp5g3 in Genome Data Viewer
    Location:
    2; 2 C3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (73908447..73911326, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (73746507..73749351, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene chimerin 1, opposite strand 3 Neighboring gene chimerin 1 Neighboring gene activating transcription factor 2 Neighboring gene predicted gene, 39851 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC124584

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ligand-gated channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    proton transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    proton-transporting ATP synthase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    ATP hydrolysis coupled proton transport IEA
    Inferred from Electronic Annotation
    more info
     
    ATP synthesis coupled proton transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    pore complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cation channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion HDA PubMed 
    proton-transporting ATP synthase complex, coupling factor F(o) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proton-transporting two-sector ATPase complex, proton-transporting domain IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ATP synthase F(0) complex subunit C3, mitochondrial
    Names
    ATP synthase lipid-binding protein, mitochondrial
    ATP synthase membrane subunit c locus 3
    ATP synthase proteolipid P3
    ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 3
    ATPase protein 9
    ATPase subunit c

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301721.1NP_001288650.1  ATP synthase F(0) complex subunit C3, mitochondrial isoform a precursor

      See identical proteins and their annotated locations for NP_001288650.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AI851824, AL844581, CF104340, CX208968
      Consensus CDS
      CCDS16136.1
      UniProtKB/Swiss-Prot
      P56384
      UniProtKB/TrEMBL
      Q14BC2
      Related
      ENSMUSP00000107627.1, ENSMUST00000111996.7
      Conserved Domains (1) summary
      MTH00222
      Location:67141
      ATP9; ATP synthase F0 subunit 9; Provisional
    2. NM_001301722.1NP_001288651.1  ATP synthase F(0) complex subunit C3, mitochondrial isoform b precursor

      See identical proteins and their annotated locations for NP_001288651.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform b, which has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AI851824, AL844581, AW554443, CF104340
      Conserved Domains (1) summary
      cl00466
      Location:6789
      ATP-synt_C; ATP synthase subunit C
    3. NM_175015.3NP_778180.1  ATP synthase F(0) complex subunit C3, mitochondrial isoform a precursor

      See identical proteins and their annotated locations for NP_778180.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AI851824, AL844581, CF104340
      Consensus CDS
      CCDS16136.1
      UniProtKB/Swiss-Prot
      P56384
      UniProtKB/TrEMBL
      Q14BC2
      Related
      ENSMUSP00000018914.2, ENSMUST00000018914.2
      Conserved Domains (1) summary
      MTH00222
      Location:67141
      ATP9; ATP synthase F0 subunit 9; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      73908447..73911326 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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