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    Tlk1 tousled-like kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 228012, updated on 5-Sep-2021

    Summary

    Official Symbol
    Tlk1provided by MGI
    Official Full Name
    tousled-like kinase 1provided by MGI
    Primary source
    MGI:MGI:2441683
    See related
    Ensembl:ENSMUSG00000041997
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930545J15Rik
    Expression
    Ubiquitous expression in liver E14 (RPKM 13.5), liver E14.5 (RPKM 11.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Tlk1 in Genome Data Viewer
    Location:
    2; 2 C2
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (70542751..70656505, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (70712407..70825816, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (70550464..70663537, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 46745 Neighboring gene golgi reassembly stacking protein 2 Neighboring gene predicted gene, 38528 Neighboring gene predicted gene, 39842 Neighboring gene F-box and WD-40 domain protein 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of chromatin assembly or disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of chromatin assembly or disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase tousled-like 1
    NP_001349892.1
    NP_766252.2
    XP_006499251.1
    XP_006499252.1
    XP_006499254.1
    XP_006499256.1
    XP_017173069.1
    XP_017173070.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362963.1NP_001349892.1  serine/threonine-protein kinase tousled-like 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL928868, BX000490
      Conserved Domains (1) summary
      cd14040
      Location:401699
      STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1
    2. NM_172664.3NP_766252.2  serine/threonine-protein kinase tousled-like 1 isoform 1

      See identical proteins and their annotated locations for NP_766252.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC051641
      Consensus CDS
      CCDS50599.1
      UniProtKB/Swiss-Prot
      Q8C0V0
      Related
      ENSMUSP00000035961.9, ENSMUST00000038584.9
      Conserved Domains (2) summary
      smart00220
      Location:467734
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14040
      Location:449747
      STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

    RNA

    1. NR_156420.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL928868, BC057369, BX000490
      Related
      ENSMUST00000135128.8
    2. NR_156421.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK045308, BX000490
      Related
      ENSMUST00000124629.2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      70542751..70656505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499193.2XP_006499256.1  serine/threonine-protein kinase tousled-like 1 isoform X3

      See identical proteins and their annotated locations for XP_006499256.1

      Conserved Domains (1) summary
      cd14040
      Location:232530
      STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1
    2. XM_006499189.4XP_006499252.1  serine/threonine-protein kinase tousled-like 1 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:449711
      PKc_like; Protein Kinases, catalytic domain
    3. XM_006499191.3XP_006499254.1  serine/threonine-protein kinase tousled-like 1 isoform X3

      See identical proteins and their annotated locations for XP_006499254.1

      Conserved Domains (1) summary
      cd14040
      Location:232530
      STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1
    4. XM_006499188.5XP_006499251.1  serine/threonine-protein kinase tousled-like 1 isoform X1

      See identical proteins and their annotated locations for XP_006499251.1

      Conserved Domains (1) summary
      cd14040
      Location:417715
      STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1
    5. XM_017317581.1XP_017173070.1  serine/threonine-protein kinase tousled-like 1 isoform X3

      Conserved Domains (1) summary
      cd14040
      Location:232530
      STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1
    6. XM_017317580.3XP_017173069.1  serine/threonine-protein kinase tousled-like 1 isoform X3

      Conserved Domains (1) summary
      cd14040
      Location:232530
      STKc_TLK1; Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1

    RNA

    1. XR_003952263.2 RNA Sequence

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