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    Ppig peptidyl-prolyl isomerase G (cyclophilin G) [ Mus musculus (house mouse) ]

    Gene ID: 228005, updated on 26-Sep-2022

    Summary

    Official Symbol
    Ppigprovided by MGI
    Official Full Name
    peptidyl-prolyl isomerase G (cyclophilin G)provided by MGI
    Primary source
    MGI:MGI:2445173
    See related
    Ensembl:ENSMUSG00000042133 AllianceGenome:MGI:2445173
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CYP; SRCyp; B230312B02Rik
    Summary
    Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding and protein peptidyl-prolyl isomerization. Predicted to be located in cytosol; nuclear matrix; and nuclear speck. Predicted to be active in cytoplasm and nucleus. Orthologous to human PPIG (peptidylprolyl isomerase G). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 10.4), CNS E14 (RPKM 6.5) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ppig in Genome Data Viewer
    Location:
    2; 2 C2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (69553092..69584403)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (69722753..69754059)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene kelch-like 41 Neighboring gene FAST kinase domains 1 Neighboring gene 60S ribosomal protein L13-like Neighboring gene coiled-coil domain containing 173 Neighboring gene phosphatase, orphan 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cyclosporin A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cyclosporin A binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein peptidyl-prolyl isomerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein peptidyl-prolyl isomerization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    peptidyl-prolyl cis-trans isomerase G
    Names
    PPIase G
    cyclophilin G
    peptidylprolyl isomerase G
    rotamase G
    NP_001074555.1
    XP_006499247.1
    XP_006499248.1
    XP_006499249.1
    XP_006499250.1
    XP_036016984.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081086.2NP_001074555.1  peptidyl-prolyl cis-trans isomerase G isoform 1

      See identical proteins and their annotated locations for NP_001074555.1

      Status: VALIDATED

      Source sequence(s)
      AL845261
      Consensus CDS
      CCDS38137.1
      UniProtKB/Swiss-Prot
      A2AR02, Q3UXE0
      Related
      ENSMUSP00000045945.9, ENSMUST00000040915.15
      Conserved Domains (2) summary
      PTZ00121
      Location:401750
      PTZ00121; MAEBL; Provisional
      cl00197
      Location:8175
      cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
    2. NM_001407461.1NP_001394390.1  peptidyl-prolyl cis-trans isomerase G isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL845261
      UniProtKB/Swiss-Prot
      Q3UXE0
    3. NM_001407462.1NP_001394391.1  peptidyl-prolyl cis-trans isomerase G isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL845261
      UniProtKB/Swiss-Prot
      Q3UXE0
    4. NM_001407463.1NP_001394392.1  peptidyl-prolyl cis-trans isomerase G isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL845261
      UniProtKB/Swiss-Prot
      Q3UXE0
    5. NM_001407464.1NP_001394393.1  peptidyl-prolyl cis-trans isomerase G isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL845261
      UniProtKB/Swiss-Prot
      Q3UXE0
    6. NM_001407465.1NP_001394394.1  peptidyl-prolyl cis-trans isomerase G isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL845261
      UniProtKB/Swiss-Prot
      Q3UXE0
    7. NM_001407466.1NP_001394395.1  peptidyl-prolyl cis-trans isomerase G isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL845261
      UniProtKB/Swiss-Prot
      Q3UXE0
    8. NM_001407468.1NP_001394397.1  peptidyl-prolyl cis-trans isomerase G isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL845261
    9. NM_001407473.1NP_001394402.1  peptidyl-prolyl cis-trans isomerase G isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL845261
    10. NM_001407474.1NP_001394403.1  peptidyl-prolyl cis-trans isomerase G isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL845261
    11. NM_001407475.1NP_001394404.1  peptidyl-prolyl cis-trans isomerase G isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL845261
    12. NM_001407476.1NP_001394405.1  peptidyl-prolyl cis-trans isomerase G isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL845261
    13. NM_001407477.1NP_001394406.1  peptidyl-prolyl cis-trans isomerase G isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL845261
    14. NM_001407478.1NP_001394407.1  peptidyl-prolyl cis-trans isomerase G isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL845261
    15. NM_001407479.1NP_001394408.1  peptidyl-prolyl cis-trans isomerase G isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL845261
    16. NM_001407480.1NP_001394409.1  peptidyl-prolyl cis-trans isomerase G isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL845261
    17. NM_001407481.1NP_001394410.1  peptidyl-prolyl cis-trans isomerase G isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL845261
    18. NM_001407482.1NP_001394411.1  peptidyl-prolyl cis-trans isomerase G isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL845261
    19. NM_001407483.1NP_001394412.1  peptidyl-prolyl cis-trans isomerase G isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL845261
    20. NM_001407484.1NP_001394413.1  peptidyl-prolyl cis-trans isomerase G isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL845261

    RNA

    1. NR_176367.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL845261

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      69553092..69584403
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499187.5XP_006499250.1  peptidyl-prolyl cis-trans isomerase G isoform X1

      UniProtKB/Swiss-Prot
      A2AR02
      Conserved Domains (2) summary
      PTZ00121
      Location:401750
      PTZ00121; MAEBL; Provisional
      cl00197
      Location:8175
      cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
    2. XM_006499184.5XP_006499247.1  peptidyl-prolyl cis-trans isomerase G isoform X1

      UniProtKB/Swiss-Prot
      A2AR02
      Related
      ENSMUSP00000088370.4, ENSMUST00000090858.10
      Conserved Domains (2) summary
      PTZ00121
      Location:401750
      PTZ00121; MAEBL; Provisional
      cl00197
      Location:8175
      cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
    3. XM_006499185.5XP_006499248.1  peptidyl-prolyl cis-trans isomerase G isoform X1

      UniProtKB/Swiss-Prot
      A2AR02
      Conserved Domains (2) summary
      PTZ00121
      Location:401750
      PTZ00121; MAEBL; Provisional
      cl00197
      Location:8175
      cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
    4. XM_006499186.4XP_006499249.1  peptidyl-prolyl cis-trans isomerase G isoform X1

      UniProtKB/Swiss-Prot
      A2AR02
      Conserved Domains (2) summary
      PTZ00121
      Location:401750
      PTZ00121; MAEBL; Provisional
      cl00197
      Location:8175
      cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
    5. XM_036161091.1XP_036016984.1  peptidyl-prolyl cis-trans isomerase G isoform X1

      Conserved Domains (2) summary
      PTZ00121
      Location:401750
      PTZ00121; MAEBL; Provisional
      cl00197
      Location:8175
      cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...