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    Pkp4 plakophilin 4 [ Mus musculus (house mouse) ]

    Gene ID: 227937, updated on 9-Sep-2018

    Summary

    Official Symbol
    Pkp4provided by MGI
    Official Full Name
    plakophilin 4provided by MGI
    Primary source
    MGI:MGI:109281
    See related
    Ensembl:ENSMUSG00000026991 Vega:OTTMUSG00000012706
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Armrp; p0071; 5031422I09Rik; 9430019K17Rik
    Expression
    Ubiquitous expression in kidney adult (RPKM 42.6), cerebellum adult (RPKM 33.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Pkp4 in Genome Data Viewer
    Location:
    2; 2 C1.1
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (59160850..59355205)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (58998907..59193262)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene uridine phosphorylase 2 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene coiled-coil domain containing 148 Neighboring gene RIKEN cDNA 5330411J11 gene Neighboring gene 40S ribosomal protein S14-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC100358, MGC105166

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cadherin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell-cell junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell-cell junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with cell-cell contact zone ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    desmosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    midbody ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with midbody ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spindle midzone ISO
    Inferred from Sequence Orthology
    more info
     
    spindle pole ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    plakophilin-4
    Names
    armadillo-related protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362990.1NP_001349919.1  plakophilin-4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL845536, BX649232
      Conserved Domains (4) summary
      smart00185
      Location:556596
      ARM; Armadillo/beta-catenin-like repeats
      pfam05642
      Location:90402
      Sporozoite_P67; Sporozoite P67 surface antigen
      sd00043
      Location:527552
      ARM; armadillo repeat [structural motif]
      cl27106
      Location:845966
      PLN03200; cellulose synthase-interactive protein; Provisional
    2. NM_001362991.1NP_001349920.1  plakophilin-4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL845536, BX649232
      Conserved Domains (4) summary
      smart00185
      Location:555595
      ARM; Armadillo/beta-catenin-like repeats
      pfam05642
      Location:90402
      Sporozoite_P67; Sporozoite P67 surface antigen
      sd00043
      Location:526551
      ARM; armadillo repeat [structural motif]
      cl27106
      Location:844965
      PLN03200; cellulose synthase-interactive protein; Provisional
    3. NM_001362992.1NP_001349921.1  plakophilin-4 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 6 and 7, encodes isoform 5.
      Source sequence(s)
      AL845536, BX649232
      Conserved Domains (4) summary
      PLN03209
      Location:72229
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:410450
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:381406
      ARM; armadillo repeat [structural motif]
      cl27106
      Location:699820
      PLN03200; cellulose synthase-interactive protein; Provisional
    4. NM_001362993.1NP_001349922.1  plakophilin-4 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 5 and 7, encodes isoform 5.
      Source sequence(s)
      AL845536, BX649232
      Conserved Domains (4) summary
      PLN03209
      Location:72229
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:410450
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:381406
      ARM; armadillo repeat [structural motif]
      cl27106
      Location:699820
      PLN03200; cellulose synthase-interactive protein; Provisional
    5. NM_001362994.1NP_001349923.1  plakophilin-4 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variants 5 and 6, encodes isoform 5.
      Source sequence(s)
      AL845536, BX649232
      Conserved Domains (4) summary
      PLN03209
      Location:72229
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:410450
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:381406
      ARM; armadillo repeat [structural motif]
      cl27106
      Location:699820
      PLN03200; cellulose synthase-interactive protein; Provisional
    6. NM_001362995.1NP_001349924.1  plakophilin-4 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variant 9, encodes isoform 6.
      Source sequence(s)
      AL845536, BX649232
      Conserved Domains (4) summary
      PLN03209
      Location:72229
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:409449
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:380405
      ARM; armadillo repeat [structural motif]
      cl27106
      Location:698819
      PLN03200; cellulose synthase-interactive protein; Provisional
    7. NM_001362996.1NP_001349925.1  plakophilin-4 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9), as well as variant 8, encodes isoform 6.
      Source sequence(s)
      AL845536, BX649232
      Conserved Domains (4) summary
      PLN03209
      Location:72229
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:409449
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:380405
      ARM; armadillo repeat [structural motif]
      cl27106
      Location:698819
      PLN03200; cellulose synthase-interactive protein; Provisional
    8. NM_001362997.1NP_001349926.1  plakophilin-4 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variants 11 and 12, encodes isoform 7.
      Source sequence(s)
      AL845536, BX649232
      Conserved Domains (3) summary
      smart00185
      Location:217257
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:188213
      ARM; armadillo repeat [structural motif]
      cl27106
      Location:506627
      PLN03200; cellulose synthase-interactive protein; Provisional
    9. NM_001362998.1NP_001349927.1  plakophilin-4 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11), as well as variants 10 and 12, encodes isoform 7.
      Source sequence(s)
      AL845536, BX649232
      Conserved Domains (3) summary
      smart00185
      Location:217257
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:188213
      ARM; armadillo repeat [structural motif]
      cl27106
      Location:506627
      PLN03200; cellulose synthase-interactive protein; Provisional
    10. NM_001362999.1NP_001349928.1  plakophilin-4 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12), as well as variants 10 and 11, encodes isoform 7.
      Source sequence(s)
      AL845536, BX649232
      Conserved Domains (3) summary
      smart00185
      Location:217257
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:188213
      ARM; armadillo repeat [structural motif]
      cl27106
      Location:506627
      PLN03200; cellulose synthase-interactive protein; Provisional
    11. NM_026361.2NP_080637.1  plakophilin-4 isoform 1

      See identical proteins and their annotated locations for NP_080637.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AA266974, AK146720, BC079848
      Consensus CDS
      CCDS16052.1
      UniProtKB/Swiss-Prot
      Q68FH0
      UniProtKB/TrEMBL
      Q3UIX3
      Related
      ENSMUSP00000099815.4, OTTMUSP00000013629, ENSMUST00000102754.10, OTTMUST00000030307
      Conserved Domains (4) summary
      smart00185
      Location:948992
      ARM; Armadillo/beta-catenin-like repeats
      cd00020
      Location:521643
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam13646
      Location:529632
      HEAT_2; HEAT repeats
      sd00043
      Location:529554
      ARM; armadillo repeat [structural motif]
    12. NM_175464.2NP_780673.2  plakophilin-4 isoform 2

      See identical proteins and their annotated locations for NP_780673.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) has a shorter C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AA266974, AK146720, BC082578
      Consensus CDS
      CCDS50588.1
      UniProtKB/Swiss-Prot
      Q68FH0
      UniProtKB/TrEMBL
      Q3UIX3
      Related
      ENSMUSP00000129836.1, ENSMUST00000168631.7
      Conserved Domains (4) summary
      smart00185
      Location:948992
      ARM; Armadillo/beta-catenin-like repeats
      cd00020
      Location:521643
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam13646
      Location:529632
      HEAT_2; HEAT repeats
      sd00043
      Location:529554
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      59160850..59355205
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499175.3XP_006499238.1  plakophilin-4 isoform X5

      Conserved Domains (4) summary
      smart00185
      Location:948992
      ARM; Armadillo/beta-catenin-like repeats
      cd00020
      Location:521643
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam13646
      Location:529632
      HEAT_2; HEAT repeats
      sd00043
      Location:529554
      ARM; armadillo repeat [structural motif]
    2. XM_017317524.1XP_017173013.1  plakophilin-4 isoform X6

      Conserved Domains (4) summary
      PLN03209
      Location:72229
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:410450
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:381406
      ARM; armadillo repeat [structural motif]
      cl27106
      Location:699820
      PLN03200; cellulose synthase-interactive protein; Provisional
    3. XM_017317546.1XP_017173035.1  plakophilin-4 isoform X7

      Conserved Domains (4) summary
      PLN03209
      Location:72229
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:409449
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:380405
      ARM; armadillo repeat [structural motif]
      cl27106
      Location:698819
      PLN03200; cellulose synthase-interactive protein; Provisional
    4. XM_006499176.2XP_006499239.1  plakophilin-4 isoform X6

      Conserved Domains (4) summary
      PLN03209
      Location:72229
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:410450
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:381406
      ARM; armadillo repeat [structural motif]
      cl27106
      Location:699820
      PLN03200; cellulose synthase-interactive protein; Provisional
    5. XM_017317549.1XP_017173038.1  plakophilin-4 isoform X8

      UniProtKB/TrEMBL
      A2AS47
      Related
      ENSMUSP00000108196.1, OTTMUSP00000023684, ENSMUST00000112577.7, OTTMUST00000030316
      Conserved Domains (3) summary
      smart00185
      Location:217257
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:188213
      ARM; armadillo repeat [structural motif]
      cl27106
      Location:506627
      PLN03200; cellulose synthase-interactive protein; Provisional
    6. XM_017317543.1XP_017173032.1  plakophilin-4 isoform X6

      Conserved Domains (4) summary
      PLN03209
      Location:72229
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:410450
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:381406
      ARM; armadillo repeat [structural motif]
      cl27106
      Location:699820
      PLN03200; cellulose synthase-interactive protein; Provisional
    7. XM_017317552.1XP_017173041.1  plakophilin-4 isoform X8

      UniProtKB/TrEMBL
      A2AS47
      Conserved Domains (3) summary
      smart00185
      Location:217257
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:188213
      ARM; armadillo repeat [structural motif]
      cl27106
      Location:506627
      PLN03200; cellulose synthase-interactive protein; Provisional
    8. XM_017317554.1XP_017173043.1  plakophilin-4 isoform X9

    9. XM_006499172.2XP_006499235.1  plakophilin-4 isoform X2

      Conserved Domains (4) summary
      smart00185
      Location:947991
      ARM; Armadillo/beta-catenin-like repeats
      cd00020
      Location:520642
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam13646
      Location:528631
      HEAT_2; HEAT repeats
      sd00043
      Location:528553
      ARM; armadillo repeat [structural motif]
    10. XM_006499173.2XP_006499236.1  plakophilin-4 isoform X3

      Conserved Domains (4) summary
      smart00185
      Location:556596
      ARM; Armadillo/beta-catenin-like repeats
      pfam05642
      Location:90402
      Sporozoite_P67; Sporozoite P67 surface antigen
      sd00043
      Location:527552
      ARM; armadillo repeat [structural motif]
      cl27106
      Location:845966
      PLN03200; cellulose synthase-interactive protein; Provisional
    11. XM_006499180.2XP_006499243.1  plakophilin-4 isoform X8

      See identical proteins and their annotated locations for XP_006499243.1

      UniProtKB/TrEMBL
      A2AS47
      Conserved Domains (3) summary
      smart00185
      Location:217257
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:188213
      ARM; armadillo repeat [structural motif]
      cl27106
      Location:506627
      PLN03200; cellulose synthase-interactive protein; Provisional
    12. XM_017317544.1XP_017173033.1  plakophilin-4 isoform X6

      Conserved Domains (4) summary
      PLN03209
      Location:72229
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:410450
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:381406
      ARM; armadillo repeat [structural motif]
      cl27106
      Location:699820
      PLN03200; cellulose synthase-interactive protein; Provisional
    13. XM_006499179.2XP_006499242.1  plakophilin-4 isoform X8

      See identical proteins and their annotated locations for XP_006499242.1

      UniProtKB/TrEMBL
      A2AS47
      Conserved Domains (3) summary
      smart00185
      Location:217257
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:188213
      ARM; armadillo repeat [structural motif]
      cl27106
      Location:506627
      PLN03200; cellulose synthase-interactive protein; Provisional
    14. XM_017317519.1XP_017173008.1  plakophilin-4 isoform X4

      Conserved Domains (4) summary
      smart00185
      Location:555595
      ARM; Armadillo/beta-catenin-like repeats
      pfam05642
      Location:90402
      Sporozoite_P67; Sporozoite P67 surface antigen
      sd00043
      Location:526551
      ARM; armadillo repeat [structural motif]
      cl27106
      Location:844965
      PLN03200; cellulose synthase-interactive protein; Provisional
    15. XM_017317541.1XP_017173030.1  plakophilin-4 isoform X6

      Conserved Domains (4) summary
      PLN03209
      Location:72229
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:410450
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:381406
      ARM; armadillo repeat [structural motif]
      cl27106
      Location:699820
      PLN03200; cellulose synthase-interactive protein; Provisional
    16. XM_017317535.1XP_017173024.1  plakophilin-4 isoform X6

      Conserved Domains (4) summary
      PLN03209
      Location:72229
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:410450
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:381406
      ARM; armadillo repeat [structural motif]
      cl27106
      Location:699820
      PLN03200; cellulose synthase-interactive protein; Provisional
    17. XM_006499171.3XP_006499234.1  plakophilin-4 isoform X1

      See identical proteins and their annotated locations for XP_006499234.1

      UniProtKB/Swiss-Prot
      Q68FH0
      Conserved Domains (4) summary
      smart00185
      Location:948992
      ARM; Armadillo/beta-catenin-like repeats
      cd00020
      Location:521643
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam13646
      Location:529632
      HEAT_2; HEAT repeats
      sd00043
      Location:529554
      ARM; armadillo repeat [structural motif]
    18. XM_006499177.3XP_006499240.1  plakophilin-4 isoform X6

      See identical proteins and their annotated locations for XP_006499240.1

      Conserved Domains (4) summary
      PLN03209
      Location:72229
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:410450
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:381406
      ARM; armadillo repeat [structural motif]
      cl27106
      Location:699820
      PLN03200; cellulose synthase-interactive protein; Provisional
    19. XM_017317547.1XP_017173036.1  plakophilin-4 isoform X7

      Conserved Domains (4) summary
      PLN03209
      Location:72229
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:409449
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:380405
      ARM; armadillo repeat [structural motif]
      cl27106
      Location:698819
      PLN03200; cellulose synthase-interactive protein; Provisional
    20. XM_017317531.1XP_017173020.1  plakophilin-4 isoform X6

      Conserved Domains (4) summary
      PLN03209
      Location:72229
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:410450
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:381406
      ARM; armadillo repeat [structural motif]
      cl27106
      Location:699820
      PLN03200; cellulose synthase-interactive protein; Provisional
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