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    Zp3 zona pellucida glycoprotein 3 [ Mus musculus (house mouse) ]

    Gene ID: 22788, updated on 8-Jul-2021

    Summary

    Official Symbol
    Zp3provided by MGI
    Official Full Name
    zona pellucida glycoprotein 3provided by MGI
    Primary source
    MGI:MGI:99215
    See related
    Ensembl:ENSMUSG00000004948
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zp-; Zp-3
    Expression
    Restricted expression toward ovary adult (RPKM 68.2) See more
    Orthologs
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    Genomic context

    See Zp3 in Genome Data Viewer
    Location:
    5 G2; 5 75.62 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (136008959..136017478)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (135980105..135988624)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (136455975..136464494)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide Neighboring gene predicted gene, 40346 Neighboring gene scavenger receptor cysteine rich family, 4 domains Neighboring gene deltex 2, E3 ubiquitin ligase Neighboring gene uroplakin 3B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acrosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables acrosin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables carbohydrate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables receptor ligand activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables receptor ligand activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables structural constituent of egg coat IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in binding of sperm to zona pellucida IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within binding of sperm to zona pellucida IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in binding of sperm to zona pellucida IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in binding of sperm to zona pellucida IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within binding of sperm to zona pellucida IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in blastocyst formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in egg coat formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in egg coat formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in humoral immune response mediated by circulating immunoglobulin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in oocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of acrosome reaction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of acrosome reaction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of antral ovarian follicle growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interferon-gamma production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interleukin-4 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of leukocyte migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of ovarian follicle development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of ovarian follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of type IV hypersensitivity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of signaling receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in egg coat ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    zona pellucida sperm-binding protein 3
    Names
    sperm receptor
    zona pellucida glycoprotein ZP3
    zona pellucida protein C

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011776.1NP_035906.1  zona pellucida sperm-binding protein 3 preproprotein

      See identical proteins and their annotated locations for NP_035906.1

      Status: VALIDATED

      Source sequence(s)
      M20026
      Consensus CDS
      CCDS19749.1
      UniProtKB/Swiss-Prot
      P10761
      Related
      ENSMUSP00000005073.7, ENSMUST00000005073.13
      Conserved Domains (3) summary
      smart00241
      Location:45304
      ZP; Zona pellucida (ZP) domain
      PHA02986
      Location:292330
      PHA02986; hypothetical protein; Provisional
      pfam00100
      Location:183302
      Zona_pellucida; Zona pellucida-like domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      136008959..136017478
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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