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    Zp2 zona pellucida glycoprotein 2 [ Mus musculus (house mouse) ]

    Gene ID: 22787, updated on 23-Jun-2021

    Summary

    Official Symbol
    Zp2provided by MGI
    Official Full Name
    zona pellucida glycoprotein 2provided by MGI
    Primary source
    MGI:MGI:99214
    See related
    Ensembl:ENSMUSG00000030911
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zp-; Zp-2
    Summary
    This gene encodes a member of the zona pellucida family of glycoproteins that play an important role in the survival of growing oocytes, successful fertilization and the passage of early embryos through the oviduct. The encoded preproprotein undergoes proteolytic processing to generate the mature polypeptide that is incorporated into the extracellular matrix surrounding mouse oocytes. Mice lacking the encoded protein develop defective zonae pellucidae that disrupt folliculogenesis, fertility and development. [provided by RefSeq, Sep 2016]
    Expression
    Restricted expression toward ovary adult (RPKM 15.6) See more
    Orthologs
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    Genomic context

    See Zp2 in Genome Data Viewer
    Location:
    7 F2; 7 64.38 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (119725985..119744514, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (120126762..120145291, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (127275875..127288804, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene dynein, axonemal, heavy chain 3 Neighboring gene ribosomal protein S9 pseudogene Neighboring gene transmembrane protein 159 Neighboring gene RIKEN cDNA 4930505K13 gene Neighboring gene ankyrin repeat and sterile alpha motif domain containing 4B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acrosin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of egg coat ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in egg coat ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in multivesicular body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    zona pellucida sperm-binding protein 2
    Names
    zona pellucida glycoprotein ZP2
    zona pellucida protein A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374631.1NP_001361560.1  zona pellucida sperm-binding protein 2 isoform 2 preproprotein

      Status: REVIEWED

      Source sequence(s)
      AC122853
      Consensus CDS
      CCDS90322.1
      Related
      ENSMUSP00000147097.2, ENSMUST00000208874.2
      Conserved Domains (1) summary
      smart00241
      Location:365630
      ZP; Zona pellucida (ZP) domain
    2. NM_011775.7NP_035905.1  zona pellucida sperm-binding protein 2 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_035905.1

      Status: REVIEWED

      Source sequence(s)
      AK135903, AK138699, DV657934
      Consensus CDS
      CCDS21792.1
      UniProtKB/Swiss-Prot
      P20239
      UniProtKB/TrEMBL
      Q3UX44
      Related
      ENSMUSP00000033207.5, ENSMUST00000033207.6
      Conserved Domains (1) summary
      smart00241
      Location:365630
      ZP; Zona pellucida (ZP) domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      119725985..119744514 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507590.4XP_006507653.1  zona pellucida sperm-binding protein 2 isoform X1

      Conserved Domains (1) summary
      smart00241
      Location:237502
      ZP; Zona pellucida (ZP) domain
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