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    Zp1 zona pellucida glycoprotein 1 [ Mus musculus (house mouse) ]

    Gene ID: 22786, updated on 26-Sep-2022

    Summary

    Official Symbol
    Zp1provided by MGI
    Official Full Name
    zona pellucida glycoprotein 1provided by MGI
    Primary source
    MGI:MGI:103073
    See related
    Ensembl:ENSMUSG00000024734 AllianceGenome:MGI:103073
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to act upstream of or within single fertilization. Located in collagen-containing extracellular matrix. Is expressed in early conceptus; ovary; and secondary oocyte. Orthologous to human ZP1 (zona pellucida glycoprotein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward ovary adult (RPKM 22.1) See more
    Orthologs
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    Genomic context

    See Zp1 in Genome Data Viewer
    Location:
    19 A; 19 7.36 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10891660..10897965, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10914296..10920601, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 109 Neighboring gene pre-mRNA processing factor 19 Neighboring gene prostaglandin D2 receptor 2 Neighboring gene coiled-coil domain containing 86 Neighboring gene membrane-spanning 4-domains, subfamily A, member 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acrosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables structural constituent of egg coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in binding of sperm to zona pellucida IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in prevention of polyspermy IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within single fertilization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in collagen-containing extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in egg coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in egg coat ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    zona pellucida sperm-binding protein 1
    Names
    zp-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009580.2NP_033606.2  zona pellucida sperm-binding protein 1 precursor

      See identical proteins and their annotated locations for NP_033606.2

      Status: VALIDATED

      Source sequence(s)
      BC125613
      Consensus CDS
      CCDS37918.1
      UniProtKB/Swiss-Prot
      Q62005, Q62016
      UniProtKB/TrEMBL
      Q059L1
      Related
      ENSMUSP00000025641.2, ENSMUST00000025641.2
      Conserved Domains (3) summary
      smart00018
      Location:226268
      PD; P or trefoil or TFF domain
      smart00241
      Location:271541
      ZP; Zona pellucida (ZP) domain
      pfam00100
      Location:404539
      Zona_pellucida; Zona pellucida-like domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      10891660..10897965 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)