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    Rabgap1 RAB GTPase activating protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 227800, updated on 11-Jul-2021

    Summary

    Official Symbol
    Rabgap1provided by MGI
    Official Full Name
    RAB GTPase activating protein 1provided by MGI
    Primary source
    MGI:MGI:2385139
    See related
    Ensembl:ENSMUSG00000035437
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gap; Gapcena; mKIAA4104
    Expression
    Ubiquitous expression in CNS E14 (RPKM 5.5), CNS E18 (RPKM 5.5) and 26 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Rabgap1 in Genome Data Viewer
    Location:
    2; 2 B
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (37333274..37463653)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (37443263..37573420)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (37298805..37421957)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 6 Neighboring gene zinc finger and BTB domain containing 26 Neighboring gene nucleoporin 37 pseudogene Neighboring gene G protein-coupled receptor 21 Neighboring gene spermatid perinuclear RNA binding protein Neighboring gene zinc finger protein 609 pseudogene Neighboring gene microRNA 5128

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4104, MGC30493

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    rab GTPase-activating protein 1
    Names
    GAP and centrosome-associated protein
    rab6 GTPase activating protein (GAP and centrosome-associated)
    rab6 GTPase-activating protein GAPCenA

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033960.1NP_001029132.1  rab GTPase-activating protein 1 isoform b

      See identical proteins and their annotated locations for NP_001029132.1

      Status: VALIDATED

      Source sequence(s)
      AK044346
      Consensus CDS
      CCDS16003.1
      UniProtKB/Swiss-Prot
      A2AWA9
      Related
      ENSMUSP00000068835.4, ENSMUST00000066055.10
      Conserved Domains (3) summary
      smart00164
      Location:558767
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd01211
      Location:140268
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam12473
      Location:302432
      DUF3694; Kinesin protein
    2. NM_001362956.1NP_001349885.1  rab GTPase-activating protein 1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL953890
      Consensus CDS
      CCDS16002.1
      Related
      ENSMUSP00000108542.2, ENSMUST00000112920.2
      Conserved Domains (4) summary
      smart00164
      Location:558767
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd01211
      Location:140268
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam12473
      Location:302432
      DUF3694; Kinesin protein
      cl25742
      Location:7891013
      ERM; Ezrin/radixin/moesin family
    3. NM_001362957.1NP_001349886.1  rab GTPase-activating protein 1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL953890
      Consensus CDS
      CCDS16003.1
      Conserved Domains (3) summary
      smart00164
      Location:558767
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd01211
      Location:140268
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam12473
      Location:302432
      DUF3694; Kinesin protein
    4. NM_001362958.1NP_001349887.1  rab GTPase-activating protein 1 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL953890
      Conserved Domains (4) summary
      smart00164
      Location:490699
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd01211
      Location:72200
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam12473
      Location:234364
      DUF3694; Kinesin protein
      cl25742
      Location:721945
      ERM; Ezrin/radixin/moesin family
    5. NM_146121.2NP_666233.2  rab GTPase-activating protein 1 isoform a

      See identical proteins and their annotated locations for NP_666233.2

      Status: VALIDATED

      Source sequence(s)
      AK220489, BY021872
      Consensus CDS
      CCDS16002.1
      UniProtKB/Swiss-Prot
      A2AWA9
      UniProtKB/TrEMBL
      B2RRC5
      Related
      ENSMUSP00000061624.6, ENSMUST00000061179.12
      Conserved Domains (4) summary
      smart00164
      Location:558767
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd01211
      Location:140268
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam12473
      Location:302432
      DUF3694; Kinesin protein
      cl25742
      Location:7891013
      ERM; Ezrin/radixin/moesin family

    RNA

    1. NR_156419.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL953890

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      37333274..37463653
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497997.5XP_006498060.1  rab GTPase-activating protein 1 isoform X2

      Conserved Domains (3) summary
      smart00164
      Location:558767
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd01211
      Location:140268
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam12473
      Location:302432
      DUF3694; Kinesin protein
    2. XM_006497995.5XP_006498058.1  rab GTPase-activating protein 1 isoform X1

      Conserved Domains (4) summary
      smart00164
      Location:540749
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd01211
      Location:122250
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam00769
      Location:771997
      ERM; Ezrin/radixin/moesin family
      pfam12473
      Location:284414
      DUF3694; Kinesin protein
    3. XM_030250053.1XP_030105913.1  rab GTPase-activating protein 1 isoform X2

      Conserved Domains (3) summary
      smart00164
      Location:558767
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd01211
      Location:140268
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam12473
      Location:302432
      DUF3694; Kinesin protein
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