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    Mapkap1 mitogen-activated protein kinase associated protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 227743, updated on 22-Aug-2021

    Summary

    Official Symbol
    Mapkap1provided by MGI
    Official Full Name
    mitogen-activated protein kinase associated protein 1provided by MGI
    Primary source
    MGI:MGI:2444554
    See related
    Ensembl:ENSMUSG00000038696
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S; Sin1; AI591529; D230039K05Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 15.7), CNS E14 (RPKM 14.9) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Mapkap1 in Genome Data Viewer
    Location:
    2; 2 B
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (34296783..34514970)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (34406771..34624958)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (34287545..34480470)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA C230014O12 gene Neighboring gene predicted gene, 54111 Neighboring gene pre B cell leukemia homeobox 3 Neighboring gene ribosomal protein S7 pseudogene Neighboring gene predicted gene, 34178 Neighboring gene ribosomal protein S3A pseudogene Neighboring gene predicted gene, 34372 Neighboring gene DnaJ (Hsp40) homolog, subfamily B, member 6 pseudogene Neighboring gene GTPase activating protein and VPS9 domains 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-3,4-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-3,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of TORC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of TORC2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    target of rapamycin complex 2 subunit MAPKAP1
    Names
    SAPK-interacting protein 1
    TORC2 subunit MAPKAP1
    mitogen-activated protein kinase 2-associated protein 1
    stress-activated map kinase-interacting protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290625.1NP_001277554.1  target of rapamycin complex 2 subunit MAPKAP1 isoform a

      See identical proteins and their annotated locations for NP_001277554.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 all encode the same isoform (a).
      Source sequence(s)
      AK132263, AL808102, AL845262, BC090644
      Consensus CDS
      CCDS15948.1
      UniProtKB/Swiss-Prot
      Q8BKH7
      Related
      ENSMUSP00000108751.2, ENSMUST00000113126.3
      Conserved Domains (3) summary
      cd13331
      Location:383490
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam05422
      Location:18129
      SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
      pfam16978
      Location:140266
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    2. NM_001290626.1NP_001277555.1  target of rapamycin complex 2 subunit MAPKAP1 isoform b

      See identical proteins and their annotated locations for NP_001277555.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon and it thus differs in its 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream in-frame start codon compared to variant 1. The encoded isoform (b) is shorter at the N-terminus compared to isoform a. Variants 3 and 5 both encode the same isoform (b).
      Source sequence(s)
      AK042154, AL845262, BB852269, BC090644
      Consensus CDS
      CCDS71035.1
      UniProtKB/Swiss-Prot
      Q8BKH7
      Related
      ENSMUSP00000123301.2, ENSMUST00000124443.8
      Conserved Domains (2) summary
      cd13331
      Location:191298
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam16978
      Location:174
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    3. NM_001362919.1NP_001349848.1  target of rapamycin complex 2 subunit MAPKAP1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 all encode the same isoform (a).
      Source sequence(s)
      AL808102, AL845262
      Consensus CDS
      CCDS15948.1
      Conserved Domains (3) summary
      cd13331
      Location:383490
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam05422
      Location:18129
      SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
      pfam16978
      Location:140266
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    4. NM_001362920.1NP_001349849.1  target of rapamycin complex 2 subunit MAPKAP1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and initiates translation at a downstream in-frame start codon compared to variant 1. The encoded isoform (b) is shorter at the N-terminus compared to isoform a. Variants 3 and 5 both encode the same isoform (b).
      Source sequence(s)
      AL808102, AL845262
      Consensus CDS
      CCDS71035.1
      Conserved Domains (2) summary
      cd13331
      Location:191298
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam16978
      Location:174
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    5. NM_001362921.1NP_001349850.1  target of rapamycin complex 2 subunit MAPKAP1 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AL808102, AL845262
      Consensus CDS
      CCDS89477.1
      Related
      ENSMUSP00000108749.2, ENSMUST00000113124.8
      Conserved Domains (3) summary
      cd13331
      Location:347454
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam05422
      Location:18129
      SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
      pfam16978
      Location:140266
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    6. NM_177345.4NP_796319.1  target of rapamycin complex 2 subunit MAPKAP1 isoform a

      See identical proteins and their annotated locations for NP_796319.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, and 4 all encode the same isoform (a).
      Source sequence(s)
      AK042154, AK052045, AL845262, BB852269, BC090644
      Consensus CDS
      CCDS15948.1
      UniProtKB/Swiss-Prot
      Q8BKH7
      Related
      ENSMUSP00000116494.2, ENSMUST00000147337.8
      Conserved Domains (3) summary
      cd13331
      Location:383490
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam05422
      Location:18129
      SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
      pfam16978
      Location:140266
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      34296783..34514970
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249984.2XP_030105844.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X1

      Conserved Domains (3) summary
      cd13331
      Location:383490
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam05422
      Location:18129
      SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
      pfam16978
      Location:140266
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    2. XM_036160892.1XP_036016785.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X5

      Conserved Domains (2) summary
      cd13331
      Location:191298
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam16978
      Location:174
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    3. XM_036160886.1XP_036016779.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X3

      Conserved Domains (3) summary
      cd13331
      Location:324431
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam05422
      Location:18129
      SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
      pfam16978
      Location:140224
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    4. XM_011239084.4XP_011237386.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X1

      See identical proteins and their annotated locations for XP_011237386.1

      UniProtKB/Swiss-Prot
      Q8BKH7
      Conserved Domains (3) summary
      cd13331
      Location:383490
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam05422
      Location:18129
      SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
      pfam16978
      Location:140266
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    5. XM_030249994.2XP_030105854.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X3

      Conserved Domains (3) summary
      cd13331
      Location:324431
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam05422
      Location:18129
      SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
      pfam16978
      Location:140224
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    6. XM_036160887.1XP_036016780.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X4

      Conserved Domains (3) summary
      cd13331
      Location:288395
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam05422
      Location:18129
      SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
      pfam16978
      Location:140224
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    7. XM_030249997.2XP_030105857.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X5

      Conserved Domains (2) summary
      cd13331
      Location:191298
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam16978
      Location:174
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    8. XM_030250001.1XP_030105861.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X5

      Conserved Domains (2) summary
      cd13331
      Location:191298
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam16978
      Location:174
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    9. XM_030250011.2XP_030105871.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X7

      Conserved Domains (2) summary
      cd13331
      Location:132239
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam16978
      Location:132
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    10. XM_030250003.2XP_030105863.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X6

      Conserved Domains (2) summary
      cd13331
      Location:155262
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam16978
      Location:174
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    11. XM_030249979.2XP_030105839.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X1

      Conserved Domains (3) summary
      cd13331
      Location:383490
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam05422
      Location:18129
      SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
      pfam16978
      Location:140266
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    12. XM_030249999.2XP_030105859.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X5

      Conserved Domains (2) summary
      cd13331
      Location:191298
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam16978
      Location:174
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    13. XM_036160899.1XP_036016792.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X5

      Conserved Domains (2) summary
      cd13331
      Location:191298
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam16978
      Location:174
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    14. XM_030249998.1XP_030105858.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X5

      Conserved Domains (2) summary
      cd13331
      Location:191298
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam16978
      Location:174
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    15. XM_006497983.3XP_006498046.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X5

      See identical proteins and their annotated locations for XP_006498046.1

      UniProtKB/Swiss-Prot
      Q8BKH7
      Conserved Domains (2) summary
      cd13331
      Location:191298
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam16978
      Location:174
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    16. XM_030249991.2XP_030105851.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X3

      Conserved Domains (3) summary
      cd13331
      Location:324431
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam05422
      Location:18129
      SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
      pfam16978
      Location:140224
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    17. XM_006497978.5XP_006498041.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X2

      UniProtKB/Swiss-Prot
      Q8BKH7
      Conserved Domains (3) summary
      cd13331
      Location:347454
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam05422
      Location:18129
      SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
      pfam16978
      Location:140266
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    18. XM_006497980.5XP_006498043.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X3

      Conserved Domains (3) summary
      cd13331
      Location:324431
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam05422
      Location:18129
      SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
      pfam16978
      Location:140224
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    19. XM_030249995.2XP_030105855.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X4

      Conserved Domains (3) summary
      cd13331
      Location:288395
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam05422
      Location:18129
      SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
      pfam16978
      Location:140224
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    20. XM_030250002.2XP_030105862.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X6

      Conserved Domains (2) summary
      cd13331
      Location:155262
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam16978
      Location:174
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    21. XM_036160901.1XP_036016794.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X7

      Conserved Domains (2) summary
      cd13331
      Location:132239
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam16978
      Location:132
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    22. XM_011239083.3XP_011237385.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X1

      See identical proteins and their annotated locations for XP_011237385.1

      UniProtKB/Swiss-Prot
      Q8BKH7
      Conserved Domains (3) summary
      cd13331
      Location:383490
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam05422
      Location:18129
      SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
      pfam16978
      Location:140266
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    23. XM_030250012.2XP_030105872.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X7

      Conserved Domains (2) summary
      cd13331
      Location:132239
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam16978
      Location:132
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    24. XM_030250004.2XP_030105864.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X6

      Conserved Domains (2) summary
      cd13331
      Location:155262
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam16978
      Location:174
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    25. XM_006497975.2XP_006498038.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X1

      See identical proteins and their annotated locations for XP_006498038.1

      UniProtKB/Swiss-Prot
      Q8BKH7
      Conserved Domains (3) summary
      cd13331
      Location:383490
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam05422
      Location:18129
      SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
      pfam16978
      Location:140266
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
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