Format

Send to:

Choose Destination
    • Showing Current items.

    Nup214 nucleoporin 214 [ Mus musculus (house mouse) ]

    Gene ID: 227720, updated on 23-Jun-2021

    Summary

    Official Symbol
    Nup214provided by MGI
    Official Full Name
    nucleoporin 214provided by MGI
    Primary source
    MGI:MGI:1095411
    See related
    Ensembl:ENSMUSG00000001855
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C; CAN; D2H9S46; BC039282; D2H9S46E
    Expression
    Ubiquitous expression in testis adult (RPKM 23.6), thymus adult (RPKM 16.1) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Nup214 in Genome Data Viewer
    Location:
    2 B; 2 21.97 cM
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (31863871..31943987)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (31974408..32053975)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (31829970..31909495)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene laminin gamma 3 Neighboring gene allograft inflammatory factor 1-like Neighboring gene BTG3 associated nuclear protein pseudogene Neighboring gene predicted gene 13609 Neighboring gene family with sequence similarity 78, member A Neighboring gene microRNA 7674 Neighboring gene predicted gene, 33126 Neighboring gene phospholipid phosphatase 7 (inactive)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC37347

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear export signal receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables structural constituent of nuclear pore IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in RNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within mRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of nucleocytoplasmic transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasmic side of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    nuclear pore complex protein Nup214
    Names
    214 kDa nucleoporin
    nucleoporin Nup214

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172268.2NP_758472.2  nuclear pore complex protein Nup214

      See identical proteins and their annotated locations for NP_758472.2

      Status: VALIDATED

      Source sequence(s)
      AK040284, AK122189, BY309166
      Consensus CDS
      CCDS38098.1
      UniProtKB/Swiss-Prot
      Q80U93
      Related
      ENSMUSP00000066492.7, ENSMUST00000065398.13
      Conserved Domains (4) summary
      COG2319
      Location:23266
      WD40; WD40 repeat [General function prediction only]
      COG5651
      Location:17302073
      COG5651; PPE-repeat protein [Function unknown]
      sd00039
      Location:3986
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:94216
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      31863871..31943987
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497945.5XP_006498008.1  nuclear pore complex protein Nup214 isoform X1

      Conserved Domains (8) summary
      PHA03247
      Location:428698
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:689880
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG2319
      Location:23266
      WD40; WD40 repeat [General function prediction only]
      COG5651
      Location:17842074
      COG5651; PPE-repeat protein [Function unknown]
      sd00039
      Location:3986
      7WD40; WD40 repeat [structural motif]
      pfam12894
      Location:155216
      ANAPC4_WD40; Anaphase-promoting complex subunit 4 WD40 domain
      pfam16768
      Location:17011859
      NupH_GANP; Nucleoporin homology of Germinal-centre associated nuclear protein
      pfam18617
      Location:19121973
      Nup214_FG; Nucleoporin Nup214 phenylalanine-glycine (FG) domain
    2. XM_036160853.1XP_036016746.1  nuclear pore complex protein Nup214 isoform X2

      Conserved Domains (5) summary
      PHA03247
      Location:26296
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:287478
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15967
      Location:780965
      Nucleoporin_FG2; Nucleoporin FG repeated region
      pfam18617
      Location:15111571
      Nup214_FG; Nucleoporin Nup214 phenylalanine-glycine (FG) domain
      cl11081
      Location:13081564
      dermokine
    3. XM_017317376.2XP_017172865.1  nuclear pore complex protein Nup214 isoform X3

      Conserved Domains (3) summary
      PRK12799
      Location:126247
      motB; flagellar motor protein MotB; Reviewed
      PHA03247
      Location:138538
      PHA03247; large tegument protein UL36; Provisional
      pfam18617
      Location:838899
      Nup214_FG; Nucleoporin Nup214 phenylalanine-glycine (FG) domain
    Support Center