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    Nup214 nucleoporin 214 [ Mus musculus (house mouse) ]

    Gene ID: 227720, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nup214provided by MGI
    Official Full Name
    nucleoporin 214provided by MGI
    Primary source
    MGI:MGI:1095411
    See related
    Ensembl:ENSMUSG00000001855 AllianceGenome:MGI:1095411
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CAN; D2H9S46E
    Summary
    A structural constituent of nuclear pore. Acts upstream of or within mRNA export from nucleus; protein import into nucleus; and regulation of cell cycle. Predicted to be located in nuclear envelope. Predicted to be part of nuclear pore. Is expressed in future spinal cord; lung; and nervous system. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; acute myeloid leukemia; and brain disease. Orthologous to human NUP214 (nucleoporin 214). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 23.6), thymus adult (RPKM 16.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Nup214 in Genome Data Viewer
    Location:
    2 B; 2 21.97 cM
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (31864446..31943204)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (31974408..32053975)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene laminin gamma 3 Neighboring gene allograft inflammatory factor 1-like Neighboring gene BTG3 associated nuclear protein pseudogene Neighboring gene STARR-seq mESC enhancer starr_04165 Neighboring gene STARR-seq mESC enhancer starr_04166 Neighboring gene predicted gene 13609 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:31889766-31889967 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:31912916-31913099 Neighboring gene family with sequence similarity 78, member A Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:31917796-31918029 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:31918647-31918863 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:31920488-31920689 Neighboring gene microRNA 7674 Neighboring gene STARR-seq mESC enhancer starr_04167 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:31934202-31934355 Neighboring gene STARR-positive B cell enhancer mm9_chr2:31936748-31937048 Neighboring gene predicted gene, 33126 Neighboring gene phospholipid phosphatase 7 (inactive)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC37347

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear export signal receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nuclear localization sequence binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclear localization sequence binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of nuclear pore IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in RNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within mRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleocytoplasmic transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of nucleocytoplasmic transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of nucleocytoplasmic transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasmic side of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nuclear pore NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    nuclear pore complex protein Nup214
    Names
    214 kDa nucleoporin
    nucleoporin Nup214

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001408097.1NP_001395026.1  nuclear pore complex protein Nup214 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL928893
    2. NM_172268.3NP_758472.2  nuclear pore complex protein Nup214 isoform 1

      See identical proteins and their annotated locations for NP_758472.2

      Status: VALIDATED

      Source sequence(s)
      AL928893
      Consensus CDS
      CCDS38098.1
      UniProtKB/Swiss-Prot
      A2ATN2, Q80U93
      Related
      ENSMUSP00000066492.7, ENSMUST00000065398.13
      Conserved Domains (4) summary
      COG2319
      Location:23266
      WD40; WD40 repeat [General function prediction only]
      COG5651
      Location:17302073
      COG5651; PPE-repeat protein [Function unknown]
      sd00039
      Location:3986
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:94216
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      31864446..31943204
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160853.1XP_036016746.1  nuclear pore complex protein Nup214 isoform X2

      UniProtKB/TrEMBL
      Q8CHS9
      Conserved Domains (5) summary
      PHA03247
      Location:26296
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:287478
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15967
      Location:780965
      Nucleoporin_FG2; Nucleoporin FG repeated region
      pfam18617
      Location:15111571
      Nup214_FG; Nucleoporin Nup214 phenylalanine-glycine (FG) domain
      cl11081
      Location:13081564
      dermokine
    2. XM_017317376.2XP_017172865.1  nuclear pore complex protein Nup214 isoform X3

      Conserved Domains (3) summary
      PRK12799
      Location:126247
      motB; flagellar motor protein MotB; Reviewed
      PHA03247
      Location:138538
      PHA03247; large tegument protein UL36; Provisional
      pfam18617
      Location:838899
      Nup214_FG; Nucleoporin Nup214 phenylalanine-glycine (FG) domain