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    Nup214 nucleoporin 214 [ Mus musculus (house mouse) ]

    Gene ID: 227720, updated on 9-Sep-2018

    Summary

    Official Symbol
    Nup214provided by MGI
    Official Full Name
    nucleoporin 214provided by MGI
    Primary source
    MGI:MGI:1095411
    See related
    Ensembl:ENSMUSG00000001855 Vega:OTTMUSG00000012954
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CAN; BC039282; D2H9S46E
    Expression
    Ubiquitous expression in testis adult (RPKM 23.6), thymus adult (RPKM 16.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Nup214 in Genome Data Viewer
    Location:
    2 B; 2 21.97 cM
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (31974418..32053975)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (31829970..31909495)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene laminin gamma 3 Neighboring gene allograft inflammatory factor 1-like Neighboring gene BTG3 associated nuclear protein pseudogene Neighboring gene predicted gene 13609 Neighboring gene microRNA 7674 Neighboring gene family with sequence similarity 78, member A Neighboring gene predicted gene, 33126 Neighboring gene phospholipid phosphatase 7 (inactive)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC37347

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    nuclear export signal receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear localization sequence binding ISO
    Inferred from Sequence Orthology
    more info
     
    structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    structural constituent of nuclear pore IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    mRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of nucleocytoplasmic transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasmic side of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    nuclear pore complex protein Nup214
    Names
    214 kDa nucleoporin
    nucleoporin Nup214

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172268.2NP_758472.2  nuclear pore complex protein Nup214

      See identical proteins and their annotated locations for NP_758472.2

      Status: VALIDATED

      Source sequence(s)
      AK040284, AK122189, BY309166
      Consensus CDS
      CCDS38098.1
      UniProtKB/Swiss-Prot
      Q80U93
      Related
      ENSMUSP00000066492.6, OTTMUSP00000013944, ENSMUST00000065398.12, OTTMUST00000031160
      Conserved Domains (4) summary
      COG2319
      Location:23266
      WD40; WD40 repeat [General function prediction only]
      COG5651
      Location:17302073
      COG5651; PPE-repeat protein [Function unknown]
      sd00039
      Location:3986
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:94216
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      31974418..32053975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497945.3XP_006498008.1  nuclear pore complex protein Nup214 isoform X1

      Conserved Domains (4) summary
      COG2319
      Location:23266
      WD40; WD40 repeat [General function prediction only]
      COG5651
      Location:17842074
      COG5651; PPE-repeat protein [Function unknown]
      sd00039
      Location:3986
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:94216
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_006497946.1XP_006498009.1  nuclear pore complex protein Nup214 isoform X2

      Conserved Domains (1) summary
      COG5651
      Location:13821672
      COG5651; PPE-repeat protein [Function unknown]
    3. XM_017317375.1XP_017172864.1  nuclear pore complex protein Nup214 isoform X3

    4. XM_017317376.1XP_017172865.1  nuclear pore complex protein Nup214 isoform X4

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