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    Exosc2 exosome component 2 [ Mus musculus (house mouse) ]

    Gene ID: 227715, updated on 31-Jan-2019

    Summary

    Official Symbol
    Exosc2provided by MGI
    Official Full Name
    exosome component 2provided by MGI
    Primary source
    MGI:MGI:2385133
    See related
    Ensembl:ENSMUSG00000039356
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rrp4
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 19.1), liver E14 (RPKM 15.6) and 25 other tissues See more
    Orthologs

    Genomic context

    See Exosc2 in Genome Data Viewer
    Location:
    2; 2 B
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (31670737..31681349)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (31526257..31536840)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene far upstream element (FUSE) binding protein 3 Neighboring gene microRNA 6998 Neighboring gene PR domain containing 12 Neighboring gene predicted gene 13427 Neighboring gene c-abl oncogene 1, non-receptor tyrosine kinase Neighboring gene pyroglutamylated RFamide peptide

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC30456

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    exosome complex component RRP4
    Names
    exosome complex exonuclease RRP4
    homolog of Yeast RRP4 (ribosomal RNA processing 4), 3'-5'-exoribonuclease

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144886.3NP_659135.1  exosome complex component RRP4

      See identical proteins and their annotated locations for NP_659135.1

      Status: VALIDATED

      Source sequence(s)
      AK166881, AL929275
      Consensus CDS
      CCDS15900.1
      UniProtKB/Swiss-Prot
      Q8VBV3
      UniProtKB/TrEMBL
      Q3TKQ3
      Related
      ENSMUSP00000043519.7, ENSMUST00000038474.13
      Conserved Domains (1) summary
      cl26026
      Location:22205
      ECR1_N; Exosome complex exonuclease RRP4 N-terminal region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      31670737..31681349
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497944.2XP_006498007.1  exosome complex component RRP4 isoform X1

      Conserved Domains (2) summary
      cd05789
      Location:254
      S1_Rrp4; S1_Rrp4: Rrp4 S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. Rrp4 protein is a subunit of the exosome complex. The exosome plays a central role in 3' to 5' RNA processing and degradation in ...
      pfam15985
      Location:5797
      KH_6; KH domain
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