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    Nup188 nucleoporin 188 [ Mus musculus (house mouse) ]

    Gene ID: 227699, updated on 26-Sep-2022

    Summary

    Official Symbol
    Nup188provided by MGI
    Official Full Name
    nucleoporin 188provided by MGI
    Primary source
    MGI:MGI:2446190
    See related
    Ensembl:ENSMUSG00000052533 AllianceGenome:MGI:2446190
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be a structural constituent of nuclear pore. Predicted to be involved in RNA export from nucleus and protein import into nucleus. Predicted to act upstream of or within mRNA transport and protein transport. Predicted to be located in nucleus. Predicted to be part of nuclear pore inner ring. Orthologous to human NUP188 (nucleoporin 188). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 50.6), thymus adult (RPKM 23.1) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Nup188 in Genome Data Viewer
    Location:
    2; 2 B
    Exon count:
    46
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30176400..30234278)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30286407..30344266)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene phytanoyl-CoA dioxygenase domain containing 1 Neighboring gene dolichol kinase Neighboring gene predicted gene, 39780 Neighboring gene SH3-domain GRB2-like endophilin B2 Neighboring gene mitoguardin 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0169

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in RNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nucleocytoplasmic transport IC
    Inferred by Curator
    more info
    PubMed 
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear pore IC
    Inferred by Curator
    more info
    PubMed 
    part_of nuclear pore inner ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    nucleoporin NUP188; nucleoporin NUP188 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410239.1NP_001397168.1  nucleoporin NUP188 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL954388
    2. NM_001410240.1NP_001397169.1  nucleoporin NUP188 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL954388
    3. NM_001410241.1NP_001397170.1  nucleoporin NUP188 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL954388
    4. NM_001410242.1NP_001397171.1  nucleoporin NUP188 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL954388
    5. NM_001410243.1NP_001397172.1  nucleoporin NUP188 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL954388
    6. NM_198304.4NP_938046.2  nucleoporin NUP188 isoform 1

      See identical proteins and their annotated locations for NP_938046.2

      Status: VALIDATED

      Source sequence(s)
      AL954388
      Consensus CDS
      CCDS15878.1
      UniProtKB/Swiss-Prot
      Q6ZQH8, Q8R3F1
      Related
      ENSMUSP00000065836.6, ENSMUST00000064447.12
      Conserved Domains (1) summary
      pfam10487
      Location:31941
      Nup188; Nucleoporin subcomplex protein binding to Pom34

    RNA

    1. NR_156132.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL954388

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      30176400..30234278
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497934.3XP_006497997.1  nucleoporin NUP188 homolog isoform X2

      Conserved Domains (1) summary
      cl29134
      Location:1747
      Nup192; Nuclear pore complex scaffold, nucleoporins 186/192/205
    2. XM_030249849.1XP_030105709.1  nucleoporin NUP188 homolog isoform X1

      Conserved Domains (1) summary
      pfam10487
      Location:4828
      Nup188; Nucleoporin subcomplex protein binding to Pom34
    3. XM_030249850.1XP_030105710.1  nucleoporin NUP188 homolog isoform X2

      Conserved Domains (1) summary
      cl29134
      Location:1747
      Nup192; Nuclear pore complex scaffold, nucleoporins 186/192/205