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    Sec16a SEC16 homolog A, endoplasmic reticulum export factor [ Mus musculus (house mouse) ]

    Gene ID: 227648, updated on 22-Aug-2021

    Summary

    Official Symbol
    Sec16aprovided by MGI
    Official Full Name
    SEC16 homolog A, endoplasmic reticulum export factorprovided by MGI
    Primary source
    MGI:MGI:2139207
    See related
    Ensembl:ENSMUSG00000026924
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p250; AU024582; C230052J16Rik
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 22.5), ovary adult (RPKM 20.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Sec16a in Genome Data Viewer
    Location:
    2; 2 A3
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (26299443..26336138, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (26409431..26446293, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (26264951..26300736, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene endosome associated trafficking regulator 1 Neighboring gene peptidase (mitochondrial processing) alpha Neighboring gene inositol polyphosphate-5-phosphatase E Neighboring gene RIKEN cDNA 0610009E02 gene Neighboring gene notch 1 Neighboring gene microRNA 6996 Neighboring gene predicted gene, 35978

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC38812

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in COPII vesicle coating IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in Golgi to plasma membrane CFTR protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endoplasmic reticulum organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endoplasmic reticulum organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein exit from endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein localization to endoplasmic reticulum exit site ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in ER to Golgi transport vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum exit site IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum exit site ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in organelle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein transport protein Sec16A
    NP_694765.2
    XP_006497973.2
    XP_006497974.1
    XP_006497976.1
    XP_011237375.1
    XP_030105628.2
    XP_036016658.1
    XP_036016660.1
    XP_036016666.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153125.2NP_694765.2  protein transport protein Sec16A

      Status: VALIDATED

      Source sequence(s)
      AA388295, AI851539, AK122242, AK162931, BC034649, BF456838, BQ950511, BU704044, CA463107, CJ098463, CK638146, CO432077, CV883992, CX236472
      Consensus CDS
      CCDS38085.1
      UniProtKB/TrEMBL
      E9QAT4, Q3TRA8, Q80U43, Q8K000
      Related
      ENSMUSP00000088796.5, ENSMUST00000091252.5
      Conserved Domains (4) summary
      cd09233
      Location:15121874
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
      pfam10697
      Location:12701332
      DUF2502; Protein of unknown function (DUF2502)
      cl25764
      Location:58285
      PAT1; Topoisomerase II-associated protein PAT1
      cl26464
      Location:6691241
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      26299443..26336138 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497910.5XP_006497973.2  protein transport protein Sec16A isoform X1

      Conserved Domains (2) summary
      cd09233
      Location:15121874
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
      PHA03247
      Location:2291
      PHA03247; large tegument protein UL36; Provisional
    2. XM_030249768.2XP_030105628.2  protein transport protein Sec16A isoform X1

      Conserved Domains (2) summary
      cd09233
      Location:15121874
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
      PHA03247
      Location:2291
      PHA03247; large tegument protein UL36; Provisional
    3. XM_011239073.3XP_011237375.1  protein transport protein Sec16A isoform X6

      Conserved Domains (4) summary
      cd09233
      Location:12801642
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
      PHA03247
      Location:6671009
      PHA03247; large tegument protein UL36; Provisional
      pfam09770
      Location:58285
      PAT1; Topoisomerase II-associated protein PAT1
      pfam10697
      Location:10381100
      DUF2502; Protein of unknown function (DUF2502)
    4. XM_036160773.1XP_036016666.1  protein transport protein Sec16A isoform X5

      Conserved Domains (2) summary
      cd09233
      Location:12801642
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
      PHA03247
      Location:2291
      PHA03247; large tegument protein UL36; Provisional
    5. XM_006497913.4XP_006497976.1  protein transport protein Sec16A isoform X4

      Conserved Domains (4) summary
      cd09233
      Location:15121874
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
      PHA03247
      Location:6691241
      PHA03247; large tegument protein UL36; Provisional
      pfam09770
      Location:58285
      PAT1; Topoisomerase II-associated protein PAT1
      pfam10697
      Location:12701332
      DUF2502; Protein of unknown function (DUF2502)
    6. XM_036160767.1XP_036016660.1  protein transport protein Sec16A isoform X2

      Conserved Domains (2) summary
      cd09233
      Location:15121874
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
      PHA03247
      Location:2291
      PHA03247; large tegument protein UL36; Provisional
    7. XM_006497911.4XP_006497974.1  protein transport protein Sec16A isoform X3

      UniProtKB/TrEMBL
      A2AIX1
      Related
      ENSMUSP00000109716.3, ENSMUST00000114082.9
      Conserved Domains (4) summary
      cd09233
      Location:15121874
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
      PHA03247
      Location:6691241
      PHA03247; large tegument protein UL36; Provisional
      pfam09770
      Location:58285
      PAT1; Topoisomerase II-associated protein PAT1
      pfam10697
      Location:12701332
      DUF2502; Protein of unknown function (DUF2502)
    8. XM_036160765.1XP_036016658.1  protein transport protein Sec16A isoform X1

      Conserved Domains (2) summary
      cd09233
      Location:15121874
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
      PHA03247
      Location:2291
      PHA03247; large tegument protein UL36; Provisional
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