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    Zkscan5 zinc finger with KRAB and SCAN domains 5 [ Mus musculus (house mouse) ]

    Gene ID: 22757, updated on 2-Oct-2018

    Summary

    Official Symbol
    Zkscan5provided by MGI
    Official Full Name
    zinc finger with KRAB and SCAN domains 5provided by MGI
    Primary source
    MGI:MGI:107533
    See related
    Ensembl:ENSMUSG00000055991 Vega:OTTMUSG00000022937
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp95; hKraba1; AI132486; AI326970
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 3.5), testis adult (RPKM 3.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Zkscan5 in Genome Data Viewer
    Location:
    5; 5 G2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (145204457..145221752)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (145965428..145982619)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2 Neighboring gene zinc finger with KRAB and SCAN domains 14 Neighboring gene zinc finger protein 655 Neighboring gene predicted gene 9710

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    zinc finger protein with KRAB and SCAN domains 5
    Names
    zfp-95
    zinc finger protein 95

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167944.1NP_001161416.1  zinc finger protein with KRAB and SCAN domains 5 isoform 2

      See identical proteins and their annotated locations for NP_001161416.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two coding exons compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      BC060248, BQ769351
      Consensus CDS
      CCDS51697.1
      UniProtKB/TrEMBL
      Q6PAK4
      Related
      ENSMUSP00000031601.7, OTTMUSP00000026381, ENSMUST00000031601.7, OTTMUST00000055163
      Conserved Domains (6) summary
      smart00431
      Location:47155
      SCAN; leucine rich region
      COG5048
      Location:250671
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:469489
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:467489
      zf-C2H2; Zinc finger, C2H2 type
      pfam02023
      Location:47134
      SCAN; SCAN domain
      pfam13465
      Location:310333
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001359187.1NP_001346116.1  zinc finger protein with KRAB and SCAN domains 5 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC127411
      Conserved Domains (5) summary
      smart00431
      Location:47155
      SCAN; leucine rich region
      COG5048
      Location:308729
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:527547
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:763787
      zf-H2C2_2; Zinc-finger double domain
      cl02581
      Location:220240
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    3. NM_001359188.1NP_001346117.1  zinc finger protein with KRAB and SCAN domains 5 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate splice junction in the 5' end compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC127411
      Conserved Domains (4) summary
      cd07765
      Location:71105
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:174595
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:393413
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:629653
      zf-H2C2_2; Zinc-finger double domain
    4. NM_001359189.1NP_001346118.1  zinc finger protein with KRAB and SCAN domains 5 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains two alternate splice junctions compared to variant 1. The resulting isoform (5) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC127411
      Conserved Domains (4) summary
      cd07765
      Location:3367
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:136557
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:355375
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:591615
      zf-H2C2_2; Zinc-finger double domain
    5. NM_001359190.1NP_001346119.1  zinc finger protein with KRAB and SCAN domains 5 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains an alternate splice junction in the 5' end and lacks two coding exons compared to variant 1. The resulting isoform (6) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AC127411
      Conserved Domains (3) summary
      COG5048
      Location:101522
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:320340
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:556580
      zf-H2C2_2; Zinc-finger double domain
    6. NM_001359191.1NP_001346120.1  zinc finger protein with KRAB and SCAN domains 5 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) uses an alternate splice junction in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (7) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC127411
      Conserved Domains (5) summary
      smart00431
      Location:47155
      SCAN; leucine rich region
      cd07765
      Location:220254
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      sd00017
      Location:343363
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:341363
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:355380
      zf-H2C2_2; Zinc-finger double domain
    7. NM_001359192.1NP_001346121.1  zinc finger protein with KRAB and SCAN domains 5 isoform 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) lacks two coding exons and uses an alternate splice junction in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (8) has a shorter and distinct C-terminus and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AC127411
      Conserved Domains (4) summary
      smart00431
      Location:47155
      SCAN; leucine rich region
      sd00017
      Location:270290
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:268290
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:282307
      zf-H2C2_2; Zinc-finger double domain
    8. NM_016683.2NP_057892.2  zinc finger protein with KRAB and SCAN domains 5 isoform 1

      See identical proteins and their annotated locations for NP_057892.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AB221634, AK173086, BC060248, BQ769351
      Consensus CDS
      CCDS39386.1
      UniProtKB/Swiss-Prot
      Q9Z1D8
      UniProtKB/TrEMBL
      Q69ZT2, Q6PAK4
      Related
      ENSMUSP00000082814.3, OTTMUSP00000026380, ENSMUST00000085671.9, OTTMUST00000055162
      Conserved Domains (7) summary
      smart00431
      Location:47155
      SCAN; leucine rich region
      COG5048
      Location:323744
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:542562
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:540562
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:220251
      KRAB; KRAB box
      pfam02023
      Location:47134
      SCAN; SCAN domain
      pfam13465
      Location:383406
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      145204457..145221752
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504823.3XP_006504886.1  zinc finger protein with KRAB and SCAN domains 5 isoform X5

      Conserved Domains (5) summary
      smart00431
      Location:47155
      SCAN; leucine rich region
      cd07765
      Location:220254
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      sd00017
      Location:343363
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:341363
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:355380
      zf-H2C2_2; Zinc-finger double domain
    2. XM_006504820.3XP_006504883.1  zinc finger protein with KRAB and SCAN domains 5 isoform X1

      Conserved Domains (4) summary
      cd07765
      Location:71105
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:174595
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:393413
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:629653
      zf-H2C2_2; Zinc-finger double domain
    3. XM_017320816.1XP_017176305.1  zinc finger protein with KRAB and SCAN domains 5 isoform X2

      Conserved Domains (4) summary
      cd07765
      Location:3367
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:136557
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:355375
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:591615
      zf-H2C2_2; Zinc-finger double domain
    4. XM_017320817.1XP_017176306.1  zinc finger protein with KRAB and SCAN domains 5 isoform X3

      Conserved Domains (3) summary
      COG5048
      Location:101522
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:320340
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:556580
      zf-H2C2_2; Zinc-finger double domain
    5. XM_006504822.2XP_006504885.1  zinc finger protein with KRAB and SCAN domains 5 isoform X4

      See identical proteins and their annotated locations for XP_006504885.1

      Conserved Domains (3) summary
      COG5048
      Location:20441
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:239259
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:80103
      zf-H2C2_2; Zinc-finger double domain
    6. XM_011241010.1XP_011239312.1  zinc finger protein with KRAB and SCAN domains 5 isoform X4

      See identical proteins and their annotated locations for XP_011239312.1

      Conserved Domains (3) summary
      COG5048
      Location:20441
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:239259
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:80103
      zf-H2C2_2; Zinc-finger double domain
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