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    FHL3 four and a half LIM domains 3 [ Homo sapiens (human) ]

    Gene ID: 2275, updated on 5-Mar-2024

    Summary

    Official Symbol
    FHL3provided by HGNC
    Official Full Name
    four and a half LIM domains 3provided by HGNC
    Primary source
    HGNC:HGNC:3704
    See related
    Ensembl:ENSG00000183386 MIM:602790; AllianceGenome:HGNC:3704
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SLIM2
    Summary
    The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
    Expression
    Ubiquitous expression in esophagus (RPKM 21.3), endometrium (RPKM 16.8) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See FHL3 in Genome Data Viewer
    Location:
    1p34.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (37996770..38005514, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (37863951..37872693, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (38462442..38471186, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene splicing factor 3a subunit 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 780 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 781 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:38456307-38456852 Neighboring gene RNA, U6 small nuclear 510, pseudogene Neighboring gene Sharpr-MPRA regulatory region 8264 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:38463160-38464081 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:38465171-38465958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:38465959-38466746 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:38469196-38470004 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 684 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 685 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 782 Neighboring gene UTP11 small subunit processome component Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:38491775-38492274 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38492441-38492993 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38492994-38493545 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 783 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 784 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 785 Neighboring gene Sharpr-MPRA regulatory region 3132 Neighboring gene POU class 3 homeobox 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of four and a half LIM domains 3 (FHL3) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC8696, MGC19547, MGC23614

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in muscle organ development TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in focal adhesion HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    four and a half LIM domains protein 3
    Names
    FHL-3
    LIM-only protein FHL3
    SLIM-2
    skeletal muscle LIM-protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243878.2NP_001230807.1  four and a half LIM domains protein 3 isoform 2

      See identical proteins and their annotated locations for NP_001230807.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL603790
      UniProtKB/TrEMBL
      Q96C98
      Related
      ENST00000485803.5
      Conserved Domains (3) summary
      cd09346
      Location:54105
      LIM3_FHL; The third LIM domain of Four and a half LIM domains protein (FHL)
      cd09434
      Location:113168
      LIM4_FHL3; The fourth LIM domain of Four and a half LIM domains protein 3 (FHL3)
      cl02475
      Location:147
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    2. NM_004468.5NP_004459.2  four and a half LIM domains protein 3 isoform 1

      See identical proteins and their annotated locations for NP_004459.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL603790
      Consensus CDS
      CCDS30678.1
      UniProtKB/Swiss-Prot
      D3DPT6, Q13643, Q6I9T0, Q9BVA2
      UniProtKB/TrEMBL
      Q9P100
      Related
      ENSP00000362107.3, ENST00000373016.4
      Conserved Domains (5) summary
      cd09346
      Location:162213
      LIM3_FHL; The third LIM domain of Four and a half LIM domains protein (FHL)
      cd09423
      Location:3694
      LIM1_FHL3; The first LIM domain of Four and a half LIM domains protein 3 (FHL3)
      cd09427
      Location:98155
      LIM2_FHL3; The second LIM domain of Four and a half LIM domains protein 3 (FHL3)
      cd09434
      Location:221276
      LIM4_FHL3; The fourth LIM domain of Four and a half LIM domains protein 3 (FHL3)
      cl02475
      Location:533
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      37996770..38005514 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      37863951..37872693 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)