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    Ppip5k2 diphosphoinositol pentakisphosphate kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 227399, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ppip5k2provided by MGI
    Official Full Name
    diphosphoinositol pentakisphosphate kinase 2provided by MGI
    Primary source
    MGI:MGI:2142810
    See related
    Ensembl:ENSMUSG00000040648
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    V; His; Vip2; Cfap1; Cfap160; Hisppd1; AW555814; mKIAA0433; D330021B20
    Expression
    Ubiquitous expression in CNS E18 (RPKM 10.9), CNS E14 (RPKM 10.8) and 26 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ppip5k2 in Genome Data Viewer
    Location:
    1; 1 D
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (97633768..97698136, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (97706043..97770411, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (99602623..99666669, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1317 Neighboring gene macrophage immunometabolism regulator Neighboring gene gypsy retrotransposon integrase 1 Neighboring gene peptidylglycine alpha-amidating monooxygenase Neighboring gene predicted gene, 31771 Neighboring gene basic transcription factor 3, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5-diphosphoinositol pentakisphosphate 3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables diphosphoinositol-pentakisphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables diphosphoinositol-pentakisphosphate kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables diphosphoinositol-pentakisphosphate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables inositol heptakisphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables inositol hexakisphosphate 1-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables inositol hexakisphosphate 3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables inositol hexakisphosphate 5-kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables inositol hexakisphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables inositol hexakisphosphate kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables inositol hexakisphosphate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables inositol-1,3,4,5,6-pentakisphosphate kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in inositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in inositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within sensory perception of sound IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2
    Names
    VIP1 homolog 2
    histidine acid phosphatase domain containing 1
    histidine acid phosphatase domain-containing protein 1
    insP6 and PP-IP5 kinase 2
    NP_776121.4
    XP_006529552.1
    XP_006529553.1
    XP_006529554.1
    XP_006529555.1
    XP_006529556.1
    XP_006529557.1
    XP_006529558.1
    XP_006529559.1
    XP_006529560.1
    XP_006529562.1
    XP_011246292.1
    XP_017175860.1
    XP_017175863.1
    XP_030109641.1
    XP_030109645.1
    XP_030109647.1
    XP_036020456.1
    XP_036020469.1
    XP_036020473.1
    XP_036020477.1
    XP_036020478.1
    XP_036020481.1
    XP_036020482.1
    XP_036020484.1
    XP_036020489.1
    XP_036020490.1
    XP_036020491.1
    XP_036020492.1
    XP_036020494.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173760.5NP_776121.4  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

      See identical proteins and their annotated locations for NP_776121.4

      Status: VALIDATED

      Source sequence(s)
      AC099860, AC102191, AK052286, AK087712, AK137392, AK138622, AK149804
      Consensus CDS
      CCDS35678.2
      UniProtKB/Swiss-Prot
      Q6ZQB6
      UniProtKB/TrEMBL
      Q8BWK5
      Related
      ENSMUSP00000043401.8, ENSMUST00000042509.13
      Conserved Domains (3) summary
      pfam00328
      Location:385900
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:50139
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
      cl17255
      Location:54343
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      97633768..97698136 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529499.4XP_006529562.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X21

      Conserved Domains (3) summary
      pfam00328
      Location:385899
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:50139
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
      cl17255
      Location:54343
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    2. XM_006529495.3XP_006529558.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X9

      Conserved Domains (3) summary
      pfam00328
      Location:385900
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:50139
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
      cl17255
      Location:54343
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    3. XM_030253785.1XP_030109645.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X14

      Conserved Domains (3) summary
      pfam00328
      Location:342857
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:50109
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
      cl17255
      Location:118300
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    4. XM_036164599.1XP_036020492.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X24

      Conserved Domains (1) summary
      pfam00328
      Location:140655
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
    5. XM_036164598.1XP_036020491.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X23

      Conserved Domains (1) summary
      pfam00328
      Location:140655
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
    6. XM_036164601.1XP_036020494.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X25

      Conserved Domains (1) summary
      pfam00328
      Location:140655
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
    7. XM_036164585.1XP_036020478.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X18

      Conserved Domains (3) summary
      pfam00328
      Location:342857
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:50109
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
      cl17255
      Location:118300
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    8. XM_036164591.1XP_036020484.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X20

      Conserved Domains (3) summary
      pfam00328
      Location:385900
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:50139
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
      cl17255
      Location:54343
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    9. XM_036164563.1XP_036020456.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X8

      Conserved Domains (3) summary
      pfam00328
      Location:342856
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:50109
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
      cl17255
      Location:118300
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    10. XM_006529497.3XP_006529560.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X16

      Conserved Domains (3) summary
      pfam00328
      Location:385900
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:50139
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
      cl17255
      Location:54343
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    11. XM_030253787.1XP_030109647.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X15

      Conserved Domains (3) summary
      pfam00328
      Location:385900
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:50139
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
      cl17255
      Location:54343
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    12. XM_017320374.2XP_017175863.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X12

      Conserved Domains (3) summary
      pfam00328
      Location:385900
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:50139
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
      cl17255
      Location:54343
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    13. XM_006529496.3XP_006529559.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X10

      Conserved Domains (3) summary
      pfam00328
      Location:385900
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:50139
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
      cl17255
      Location:54343
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    14. XM_006529489.2XP_006529552.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X1

      See identical proteins and their annotated locations for XP_006529552.1

      Related
      ENSMUSP00000108466.2, ENSMUST00000112845.8
      Conserved Domains (3) summary
      pfam00328
      Location:385900
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:50139
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
      cl17255
      Location:54343
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    15. XM_030253781.2XP_030109641.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X11

      Conserved Domains (3) summary
      pfam00328
      Location:385899
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:50139
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
      cl17255
      Location:54343
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    16. XM_036164588.1XP_036020481.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X19

      Conserved Domains (2) summary
      pfam00328
      Location:271786
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      cl17255
      Location:124229
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    17. XM_011247990.1XP_011246292.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X7

      Conserved Domains (3) summary
      pfam00328
      Location:342857
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:50109
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
      cl17255
      Location:118300
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    18. XM_006529491.2XP_006529554.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X2

      Conserved Domains (3) summary
      pfam00328
      Location:385899
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:50139
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
      cl17255
      Location:54343
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    19. XM_006529494.2XP_006529557.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X6

      Conserved Domains (3) summary
      pfam00328
      Location:385900
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:50139
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
      cl17255
      Location:54343
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    20. XM_017320371.1XP_017175860.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X5

      Conserved Domains (3) summary
      pfam00328
      Location:385900
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:50139
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
      cl17255
      Location:54343
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    21. XM_006529493.2XP_006529556.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X4

      Conserved Domains (3) summary
      pfam00328
      Location:385900
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:50139
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
      cl17255
      Location:54343
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    22. XM_006529492.2XP_006529555.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X3

      Conserved Domains (3) summary
      pfam00328
      Location:385900
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:50139
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
      cl17255
      Location:54343
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    23. XM_036164576.1XP_036020469.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X9

      Conserved Domains (3) summary
      pfam00328
      Location:385900
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:50139
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
      cl17255
      Location:54343
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    24. XM_036164589.1XP_036020482.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X19

      Conserved Domains (2) summary
      pfam00328
      Location:271786
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      cl17255
      Location:124229
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    25. XM_036164596.1XP_036020489.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X22

      Conserved Domains (1) summary
      pfam00328
      Location:140655
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
    26. XM_036164597.1XP_036020490.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X22

      Conserved Domains (1) summary
      pfam00328
      Location:140655
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
    27. XM_036164584.1XP_036020477.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X17

      Conserved Domains (3) summary
      pfam00328
      Location:385899
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:50139
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
      cl17255
      Location:54343
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    28. XM_006529490.3XP_006529553.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X1

      See identical proteins and their annotated locations for XP_006529553.1

      Conserved Domains (3) summary
      pfam00328
      Location:385900
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:50139
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
      cl17255
      Location:54343
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    29. XM_036164580.1XP_036020473.1  inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X13

      Conserved Domains (3) summary
      pfam00328
      Location:385899
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
      pfam18086
      Location:50139
      PPIP5K2_N; Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain
      cl17255
      Location:54343
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
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