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    Dgkd diacylglycerol kinase, delta [ Mus musculus (house mouse) ]

    Gene ID: 227333, updated on 22-Aug-2021

    Summary

    Official Symbol
    Dgkdprovided by MGI
    Official Full Name
    diacylglycerol kinase, deltaprovided by MGI
    Primary source
    MGI:MGI:2138334
    See related
    Ensembl:ENSMUSG00000070738
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DGKdel; dgkd-2; AI841987; DGKdelta; D330025K09
    Expression
    Ubiquitous expression in thymus adult (RPKM 36.4), spleen adult (RPKM 18.4) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dgkd in Genome Data Viewer
    Location:
    1; 1 D
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (87780942..87872900)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (87853264..87945177)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (89749862..89841064)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene autophagy related 16-like 1 (S. cerevisiae) Neighboring gene predicted gene, 53572 Neighboring gene small Cajal body-specific RNA 6 Neighboring gene S-antigen, retina and pineal gland (arrestin) Neighboring gene predicted gene, 19582 Neighboring gene ubiquitin specific peptidase 40 Neighboring gene UDP glycosyltransferase 1 family, polypeptide A10 pseudogene Neighboring gene karyopherin (importin) alpha 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0145

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables NAD+ kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables diacylglycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables diacylglycerol kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables diacylglycerol kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in diacylglycerol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in diacylglycerol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within diacylglycerol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in lipid phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in lipid phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipid phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein kinase C signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phosphatidic acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of clathrin-dependent endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein kinase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to organic substance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in clathrin-coated pit ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    diacylglycerol kinase delta
    Names
    DAG kinase delta
    NP_808314.2
    XP_006529534.1
    XP_006529535.1
    XP_011246290.1
    XP_017175841.1
    XP_030109593.1
    XP_036020405.1
    XP_036020407.1
    XP_036020416.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177646.3NP_808314.2  diacylglycerol kinase delta

      Status: VALIDATED

      Source sequence(s)
      AC102630, AC162281
      Consensus CDS
      CCDS48312.1
      UniProtKB/TrEMBL
      E9PUQ8
      Related
      ENSMUSP00000027517.8, ENSMUST00000027517.14
      Conserved Domains (6) summary
      cd09575
      Location:11471211
      SAM_DGK-delta; SAM domain of diacylglycerol kinase delta
      smart00045
      Location:765922
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:323445
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd13274
      Location:55151
      PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
      cd20847
      Location:140224
      C1_DGKdelta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase delta (DAG kinase delta) and similar proteins
      cd20893
      Location:231291
      C1_DGKdelta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase delta (DAG kinase delta) and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      87780942..87872900
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529472.5XP_006529535.1  diacylglycerol kinase delta isoform X2

      Conserved Domains (4) summary
      smart00045
      Location:765922
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:323445
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:164213
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd13274
      Location:55151
      PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
    2. XM_036164514.1XP_036020407.1  diacylglycerol kinase delta isoform X4

      Conserved Domains (6) summary
      cd09575
      Location:11091173
      SAM_DGK-delta; SAM domain of diacylglycerol kinase delta
      smart00046
      Location:323445
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd13274
      Location:55151
      PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
      cd20847
      Location:140224
      C1_DGKdelta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase delta (DAG kinase delta) and similar proteins
      cd20893
      Location:231291
      C1_DGKdelta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase delta (DAG kinase delta) and similar proteins
      cl02440
      Location:765884
      DAGK_acc; Diacylglycerol kinase accessory domain
    3. XM_006529471.4XP_006529534.1  diacylglycerol kinase delta isoform X1

      Conserved Domains (5) summary
      smart00045
      Location:765922
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:323445
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:164213
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd13274
      Location:55151
      PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
      cl15755
      Location:11471193
      SAM_superfamily; SAM (Sterile alpha motif )
    4. XM_036164512.1XP_036020405.1  diacylglycerol kinase delta isoform X3

      Conserved Domains (6) summary
      smart00046
      Location:323445
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd13274
      Location:55151
      PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
      cd20847
      Location:140224
      C1_DGKdelta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase delta (DAG kinase delta) and similar proteins
      cd20893
      Location:231291
      C1_DGKdelta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase delta (DAG kinase delta) and similar proteins
      cl02440
      Location:765884
      DAGK_acc; Diacylglycerol kinase accessory domain
      cl15755
      Location:11091155
      SAM_superfamily; SAM (Sterile alpha motif )
    5. XM_030253733.2XP_030109593.1  diacylglycerol kinase delta isoform X5

      Conserved Domains (5) summary
      smart00045
      Location:632789
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:190312
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:3180
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl15755
      Location:10141060
      SAM_superfamily; SAM (Sterile alpha motif )
      cl17171
      Location:118
      PH-like; Pleckstrin homology-like domain
    6. XM_036164523.1XP_036020416.1  diacylglycerol kinase delta isoform X6

      Conserved Domains (5) summary
      cd09575
      Location:10141078
      SAM_DGK-delta; SAM domain of diacylglycerol kinase delta
      smart00045
      Location:632789
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:190312
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd20847
      Location:791
      C1_DGKdelta_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase delta (DAG kinase delta) and similar proteins
      cd20893
      Location:98158
      C1_DGKdelta_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase delta (DAG kinase delta) and similar proteins
    7. XM_011247988.4XP_011246290.1  diacylglycerol kinase delta isoform X5

      See identical proteins and their annotated locations for XP_011246290.1

      Conserved Domains (5) summary
      smart00045
      Location:632789
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:190312
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:3180
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl15755
      Location:10141060
      SAM_superfamily; SAM (Sterile alpha motif )
      cl17171
      Location:118
      PH-like; Pleckstrin homology-like domain
    8. XM_017320352.3XP_017175841.1  diacylglycerol kinase delta isoform X5

      Conserved Domains (5) summary
      smart00045
      Location:632789
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:190312
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:3180
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl15755
      Location:10141060
      SAM_superfamily; SAM (Sterile alpha motif )
      cl17171
      Location:118
      PH-like; Pleckstrin homology-like domain

    RNA

    1. XR_003955002.2 RNA Sequence

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