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    Dgkd diacylglycerol kinase, delta [ Mus musculus (house mouse) ]

    Gene ID: 227333, updated on 28-Oct-2018

    Summary

    Official Symbol
    Dgkdprovided by MGI
    Official Full Name
    diacylglycerol kinase, deltaprovided by MGI
    Primary source
    MGI:MGI:2138334
    See related
    Ensembl:ENSMUSG00000070738 Vega:OTTMUSG00000048195
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    dgkd-2; AI841987; DGKdelta; D330025K09
    Expression
    Ubiquitous expression in thymus adult (RPKM 36.4), spleen adult (RPKM 18.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Dgkd in Genome Data Viewer
    Location:
    1; 1 D
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (87853273..87945177)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (89749862..89841064)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene autophagy related 16-like 1 (S. cerevisiae) Neighboring gene small Cajal body-specific RNA 6 Neighboring gene S-antigen, retina and pineal gland (arrestin) Neighboring gene predicted gene, 38609 Neighboring gene predicted gene, 19582 Neighboring gene ubiquitin specific peptidase 40 Neighboring gene UDP glycosyltransferase 1 family, polypeptide A10 pseudogene Neighboring gene karyopherin (importin) alpha 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0145

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    diacylglycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    diacylglycerol kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    diacylglycerol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    diacylglycerol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    glycerolipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lipid phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    response to organic substance ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    diacylglycerol kinase delta
    NP_808314.2
    XP_006529534.1
    XP_006529535.1
    XP_006529536.1
    XP_006529537.1
    XP_011246290.1
    XP_017175841.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177646.3NP_808314.2  diacylglycerol kinase delta

      Status: VALIDATED

      Source sequence(s)
      AC102630, AC162281
      Consensus CDS
      CCDS48312.1
      UniProtKB/TrEMBL
      E9PUQ8
      Related
      ENSMUSP00000027517.7, OTTMUSP00000067491, ENSMUST00000027517.13, OTTMUST00000123739
      Conserved Domains (7) summary
      cd09575
      Location:11471211
      SAM_DGK-delta; SAM domain of diacylglycerol kinase delta
      smart00454
      Location:11481211
      SAM; Sterile alpha motif
      smart00045
      Location:765922
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:323445
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:164213
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd13274
      Location:55151
      PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
      pfam00169
      Location:54142
      PH; PH domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      87853273..87945177
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529472.3XP_006529535.1  diacylglycerol kinase delta isoform X2

      Conserved Domains (5) summary
      smart00045
      Location:765922
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:323445
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:164213
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd13274
      Location:55151
      PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
      pfam00169
      Location:54142
      PH; PH domain
    2. XM_006529471.2XP_006529534.1  diacylglycerol kinase delta isoform X1

      Conserved Domains (7) summary
      smart00454
      Location:11481195
      SAM; Sterile alpha motif
      smart00045
      Location:765922
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:323445
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:164213
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd13274
      Location:55151
      PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain
      pfam00169
      Location:54142
      PH; PH domain
      cl15755
      Location:11471193
      SAM_superfamily; SAM (Sterile alpha motif )
    3. XM_006529473.1XP_006529536.1  diacylglycerol kinase delta isoform X3

      See identical proteins and their annotated locations for XP_006529536.1

      Conserved Domains (6) summary
      smart00454
      Location:10151062
      SAM; Sterile alpha motif
      smart00045
      Location:632789
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:190312
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:3180
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl15755
      Location:10141060
      SAM_superfamily; SAM (Sterile alpha motif )
      cl17171
      Location:118
      PH-like; Pleckstrin homology-like domain
    4. XM_011247988.2XP_011246290.1  diacylglycerol kinase delta isoform X3

      See identical proteins and their annotated locations for XP_011246290.1

      Conserved Domains (6) summary
      smart00454
      Location:10151062
      SAM; Sterile alpha motif
      smart00045
      Location:632789
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:190312
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:3180
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl15755
      Location:10141060
      SAM_superfamily; SAM (Sterile alpha motif )
      cl17171
      Location:118
      PH-like; Pleckstrin homology-like domain
    5. XM_006529474.3XP_006529537.1  diacylglycerol kinase delta isoform X3

      See identical proteins and their annotated locations for XP_006529537.1

      Conserved Domains (6) summary
      smart00454
      Location:10151062
      SAM; Sterile alpha motif
      smart00045
      Location:632789
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:190312
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:3180
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl15755
      Location:10141060
      SAM_superfamily; SAM (Sterile alpha motif )
      cl17171
      Location:118
      PH-like; Pleckstrin homology-like domain
    6. XM_017320352.1XP_017175841.1  diacylglycerol kinase delta isoform X3

      Conserved Domains (6) summary
      smart00454
      Location:10151062
      SAM; Sterile alpha motif
      smart00045
      Location:632789
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:190312
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:3180
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cl15755
      Location:10141060
      SAM_superfamily; SAM (Sterile alpha motif )
      cl17171
      Location:118
      PH-like; Pleckstrin homology-like domain

    RNA

    1. XR_001784183.1 RNA Sequence

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