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    Gigyf2 GRB10 interacting GYF protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 227331, updated on 5-Aug-2018

    Summary

    Official Symbol
    Gigyf2provided by MGI
    Official Full Name
    GRB10 interacting GYF protein 2provided by MGI
    Primary source
    MGI:MGI:2138584
    See related
    Ensembl:ENSMUSG00000048000 Vega:OTTMUSG00000037064
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tnrc15; AI852361; AW259676; BC006835; mKIAA0642; 2610016F01Rik; A830080H02Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 11.1), CNS E11.5 (RPKM 9.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Gigyf2 in Genome Data Viewer
    Location:
    1; 1 C5-D
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (87326981..87450810)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (89223573..89347385)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4E member 2 Neighboring gene EF hand domain containing 1 Neighboring gene predicted gene, 41911 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 13 Neighboring gene secondary ossification center associated regulator of chondrocyte maturation Neighboring gene neuronal guanine nucleotide exchange factor Neighboring gene predicted gene 6153

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC38689

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    proline-rich region binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular protein metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    homeostasis of number of cells within a tissue IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    insulin-like growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    insulin-like growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic G1 DNA damage checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    musculoskeletal movement IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    neuromuscular process controlling balance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    posttranscriptional gene silencing ISO
    Inferred from Sequence Orthology
    more info
     
    spinal cord motor neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    endosome ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    proximal dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proximal dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    GRB10-interacting GYF protein 2; PERQ amino acid-rich with GYF domain-containing protein 2
    Names
    trinucleotide repeat containing 15

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110212.2NP_001103682.1  GRB10-interacting GYF protein 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the coding region compared to variant 1. The resulting protein (isoform b) is shorter but has the same N- and C- termini compared to isoform a.
      Source sequence(s)
      AC157811, AC158961, AK079246, AK122337
      Consensus CDS
      CCDS56636.1
      UniProtKB/Swiss-Prot
      Q6Y7W8
      UniProtKB/TrEMBL
      G3UYG6, Q8C585
      Related
      ENSMUSP00000134077.1, OTTMUSP00000053200, ENSMUST00000172794.7, OTTMUST00000095335
      Conserved Domains (1) summary
      cd00072
      Location:528583
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
    2. NM_146112.4NP_666224.3  GRB10-interacting GYF protein 2 isoform a

      See identical proteins and their annotated locations for NP_666224.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform a).
      Source sequence(s)
      AC157811, BC089036, BY117987
      Consensus CDS
      CCDS15133.1
      UniProtKB/Swiss-Prot
      Q6Y7W8
      Related
      ENSMUSP00000027475.8, OTTMUSP00000053203, ENSMUST00000027475.14, OTTMUST00000095340
      Conserved Domains (1) summary
      cd00072
      Location:534589
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      87326981..87450810
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320347.1XP_017175836.1  PERQ amino acid-rich with GYF domain-containing protein 2 isoform X3

    2. XM_006529466.1XP_006529529.1  PERQ amino acid-rich with GYF domain-containing protein 2 isoform X2

      Conserved Domains (1) summary
      cd00072
      Location:533588
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
    3. XM_006529467.1XP_006529530.1  PERQ amino acid-rich with GYF domain-containing protein 2 isoform X4

      Conserved Domains (1) summary
      cd00072
      Location:527582
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
    4. XM_006529468.1XP_006529531.1  PERQ amino acid-rich with GYF domain-containing protein 2 isoform X5

      Conserved Domains (1) summary
      cd00072
      Location:483538
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
    5. XM_006529469.1XP_006529532.1  PERQ amino acid-rich with GYF domain-containing protein 2 isoform X6

      See identical proteins and their annotated locations for XP_006529532.1

      Conserved Domains (1) summary
      cd00072
      Location:477532
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
    6. XM_006529464.2XP_006529527.1  PERQ amino acid-rich with GYF domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006529527.1

      UniProtKB/Swiss-Prot
      Q6Y7W8
      Conserved Domains (1) summary
      cd00072
      Location:534589
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
    7. XM_006529465.3XP_006529528.1  PERQ amino acid-rich with GYF domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006529528.1

      UniProtKB/Swiss-Prot
      Q6Y7W8
      Related
      ENSMUSP00000133327.1, OTTMUSP00000053206, ENSMUST00000174501.7, OTTMUST00000095344
      Conserved Domains (1) summary
      cd00072
      Location:534589
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
    8. XM_006529470.3XP_006529533.1  PERQ amino acid-rich with GYF domain-containing protein 2 isoform X7

      Conserved Domains (1) summary
      cd00072
      Location:380435
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.

    RNA

    1. XR_387164.1 RNA Sequence

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