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    Gigyf2 GRB10 interacting GYF protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 227331, updated on 23-Jun-2021

    Summary

    Official Symbol
    Gigyf2provided by MGI
    Official Full Name
    GRB10 interacting GYF protein 2provided by MGI
    Primary source
    MGI:MGI:2138584
    See related
    Ensembl:ENSMUSG00000048000
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tnrc; Tnrc15; AI852361; AW259676; BC006835; mKIAA0642; 2610016F01Rik; A830080H02Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 11.1), CNS E11.5 (RPKM 9.9) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Gigyf2 in Genome Data Viewer
    Location:
    1; 1 C5- D
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (87254653..87378532)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (87326931..87450810)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (89223573..89347385)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26187 Neighboring gene EF hand domain containing 1 Neighboring gene predicted gene, 41911 Neighboring gene predicted gene, 22549 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 13 Neighboring gene secondary ossification center associated regulator of chondrocyte maturation Neighboring gene neuronal guanine nucleotide exchange factor Neighboring gene predicted gene 6153

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC38689

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables proline-rich region binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular protein metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within homeostasis of number of cells within a tissue IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in insulin-like growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within insulin-like growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in insulin-like growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mitotic G1 DNA damage checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within musculoskeletal movement IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuromuscular process controlling balance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in posttranscriptional gene silencing ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within spinal cord motor neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in perikaryon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in proximal dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in proximal dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in proximal dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    GRB10-interacting GYF protein 2
    Names
    PERQ amino acid-rich with GYF domain-containing protein 2
    trinucleotide repeat containing 15

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110212.2NP_001103682.1  GRB10-interacting GYF protein 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the coding region compared to variant 1. The resulting protein (isoform b) is shorter but has the same N- and C- termini compared to isoform a.
      Source sequence(s)
      AC157811, AC158961, AK079246, AK122337
      Consensus CDS
      CCDS56636.1
      UniProtKB/Swiss-Prot
      Q6Y7W8
      UniProtKB/TrEMBL
      G3UYG6, Q8C585
      Related
      ENSMUSP00000134077.2, ENSMUST00000172794.8
      Conserved Domains (2) summary
      PTZ00449
      Location:324468
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd00072
      Location:528583
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
    2. NM_146112.4NP_666224.3  GRB10-interacting GYF protein 2 isoform a

      See identical proteins and their annotated locations for NP_666224.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform a).
      Source sequence(s)
      AC157811, BC089036, BY117987
      Consensus CDS
      CCDS15133.1
      UniProtKB/Swiss-Prot
      Q6Y7W8
      Related
      ENSMUSP00000027475.9, ENSMUST00000027475.15
      Conserved Domains (2) summary
      PTZ00449
      Location:330474
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd00072
      Location:534589
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      87254653..87378532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320347.2XP_017175836.1  GRB10-interacting GYF protein 2 isoform X3

      Conserved Domains (2) summary
      PTZ00449
      Location:330474
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd00072
      Location:534589
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
    2. XM_006529466.2XP_006529529.1  GRB10-interacting GYF protein 2 isoform X2

      Conserved Domains (2) summary
      PHA03307
      Location:292486
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00072
      Location:533588
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
    3. XM_006529467.2XP_006529530.1  GRB10-interacting GYF protein 2 isoform X5

      Conserved Domains (2) summary
      PHA03307
      Location:286480
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00072
      Location:527582
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
    4. XM_006529468.2XP_006529531.1  GRB10-interacting GYF protein 2 isoform X6

      Conserved Domains (2) summary
      PTZ00449
      Location:279423
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd00072
      Location:483538
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
    5. XM_006529469.2XP_006529532.1  GRB10-interacting GYF protein 2 isoform X7

      See identical proteins and their annotated locations for XP_006529532.1

      Conserved Domains (2) summary
      PTZ00449
      Location:273417
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd00072
      Location:477532
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
    6. XM_006529464.4XP_006529527.1  GRB10-interacting GYF protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006529527.1

      UniProtKB/Swiss-Prot
      Q6Y7W8
      Conserved Domains (2) summary
      PTZ00449
      Location:330474
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd00072
      Location:534589
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
    7. XM_036164496.1XP_036020389.1  GRB10-interacting GYF protein 2 isoform X4

      Conserved Domains (2) summary
      PTZ00449
      Location:324468
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd00072
      Location:528583
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
    8. XM_036164500.1XP_036020393.1  GRB10-interacting GYF protein 2 isoform X4

      Conserved Domains (2) summary
      PTZ00449
      Location:324468
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd00072
      Location:528583
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
    9. XM_006529465.5XP_006529528.1  GRB10-interacting GYF protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006529528.1

      UniProtKB/Swiss-Prot
      Q6Y7W8
      Related
      ENSMUSP00000133327.2, ENSMUST00000174501.8
      Conserved Domains (2) summary
      PTZ00449
      Location:330474
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd00072
      Location:534589
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
    10. XM_006529470.5XP_006529533.1  GRB10-interacting GYF protein 2 isoform X8

      Conserved Domains (2) summary
      PTZ00449
      Location:176320
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd00072
      Location:380435
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.

    RNA

    1. XR_387164.2 RNA Sequence

    2. XR_004941998.1 RNA Sequence

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