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    Mpp4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) [ Mus musculus (house mouse) ]

    Gene ID: 227157, updated on 23-Jun-2021

    Summary

    Official Symbol
    Mpp4provided by MGI
    Official Full Name
    membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)provided by MGI
    Primary source
    MGI:MGI:2386681
    See related
    Ensembl:ENSMUSG00000079550
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DLG; Dlg6
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 7.2), liver adult (RPKM 3.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mpp4 in Genome Data Viewer
    Location:
    1; 1 C1.3
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (59160094..59202548, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (59120935..59163389, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (59177779..59220233, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene C2 calcium dependent domain containing 6 Neighboring gene predicted gene, 25502 Neighboring gene transmembrane protein 237 Neighboring gene predicted gene, 19125 Neighboring gene alsin Rho guanine nucleotide exchange factor Neighboring gene predicted gene, 33667 Neighboring gene cyclin-dependent kinase 15 Neighboring gene VISTA enhancer mm1575

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein localization to synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basal part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cone cell pedicle IC
    Inferred by Curator
    more info
    PubMed 
    located_in cone cell pedicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in rod spherule IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    MAGUK p55 subfamily member 4
    Names
    discs large homolog 6
    mDLG6
    membrane palmitoylated protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164682.1NP_001158154.1  MAGUK p55 subfamily member 4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK044682, BC061694, BM945398, DV648961
      Consensus CDS
      CCDS48272.1
      UniProtKB/Swiss-Prot
      Q6P7F1
      UniProtKB/TrEMBL
      D3Z0G8
      Related
      ENSMUSP00000109914.3, ENSMUST00000114275.9
      Conserved Domains (6) summary
      smart00569
      Location:66100
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12034
      Location:264324
      SH3_MPP4; Src Homology 3 domain of Membrane Protein, Palmitoylated 4 (or MAGUK p55 subfamily member 4)
      smart00072
      Location:454637
      GuKc; Guanylate kinase homologues
      cd00992
      Location:171250
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:446636
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:108154
      L27; L27 domain
    2. NM_145143.3NP_660125.2  MAGUK p55 subfamily member 4 isoform 2

      See identical proteins and their annotated locations for NP_660125.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      BC061694, BI737565
      Consensus CDS
      CCDS48271.1
      UniProtKB/Swiss-Prot
      Q6P7F1
      Related
      ENSMUSP00000077914.8, ENSMUST00000078874.14
      Conserved Domains (6) summary
      smart00569
      Location:4781
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12034
      Location:245305
      SH3_MPP4; Src Homology 3 domain of Membrane Protein, Palmitoylated 4 (or MAGUK p55 subfamily member 4)
      smart00072
      Location:435618
      GuKc; Guanylate kinase homologues
      cd00992
      Location:152231
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:427617
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:89135
      L27; L27 domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      59160094..59202548 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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