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    Zfp57 zinc finger protein 57 [ Mus musculus (house mouse) ]

    Gene ID: 22715, updated on 22-Aug-2021

    Summary

    Official Symbol
    Zfp57provided by MGI
    Official Full Name
    zinc finger protein 57provided by MGI
    Primary source
    MGI:MGI:99204
    See related
    Ensembl:ENSMUSG00000036036
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G19; Zfp-57
    Expression
    Biased expression in CNS E18 (RPKM 66.8), CNS E14 (RPKM 62.8) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Zfp57 in Genome Data Viewer
    Location:
    17 B1; 17
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (37307060..37326196)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (37001163..37010729)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (37138108..37147674)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene histocompatibility 2, M region locus 6, pseudogene Neighboring gene RIKEN cDNA 2410137M14 gene Neighboring gene histocompatibility 2, M region locus 4, pseudogene Neighboring gene histocompatibility 2, M region locus 5 Neighboring gene myelin oligodendrocyte glycoprotein Neighboring gene gamma-aminobutyric acid (GABA) B receptor, 1 Neighboring gene olfactory receptor 90

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded methylated DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA methylation involved in embryo development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in DNA methylation involved in embryo development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in DNA methylation involved in embryo development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within genetic imprinting IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in maintenance of DNA methylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in maintenance of imprinting at mating-type locus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of gene expression by genetic imprinting IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of gene expression by genetic imprinting IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of gene expression by genetic imprinting ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of genetic imprinting IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013745.2NP_001013767.1  zinc finger protein 57 isoform 1

      See identical proteins and their annotated locations for NP_001013767.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      BC052028, CF731693, CR956641
      Consensus CDS
      CCDS28733.1
      UniProtKB/Swiss-Prot
      Q8C6P8
      Related
      ENSMUSP00000065811.8, ENSMUST00000069250.14
      Conserved Domains (4) summary
      smart00349
      Location:1572
      KRAB; krueppel associated box
      COG5048
      Location:139309
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:92134
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:169190
      zf-C2H2; Zinc finger, C2H2 type
    2. NM_001168501.1NP_001161973.1  zinc finger protein 57 isoform 1

      See identical proteins and their annotated locations for NP_001161973.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs at the 5' end compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AV579696, BC052028, CR956641
      Consensus CDS
      CCDS28733.1
      UniProtKB/Swiss-Prot
      Q8C6P8
      Related
      ENSMUSP00000134418.2, ENSMUST00000174524.8
      Conserved Domains (4) summary
      smart00349
      Location:1572
      KRAB; krueppel associated box
      COG5048
      Location:139309
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:92134
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:169190
      zf-C2H2; Zinc finger, C2H2 type
    3. NM_001168502.1NP_001161974.1  zinc finger protein 57 isoform 2

      See identical proteins and their annotated locations for NP_001161974.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs at the 5' end and uses an alternate, in-frame acceptor splice site at one of the coding exons compared to variant 1. This results in a shorter isoform (2) missing three internal aa compared to isoform 1.
      Source sequence(s)
      AK139625, BC052028, CR956641
      Consensus CDS
      CCDS50106.1
      UniProtKB/Swiss-Prot
      Q8C6P8
      Related
      ENSMUSP00000087414.7, ENSMUST00000089968.13
      Conserved Domains (4) summary
      smart00349
      Location:1269
      KRAB; krueppel associated box
      COG5048
      Location:136306
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:89131
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:166187
      zf-C2H2; Zinc finger, C2H2 type

    RNA

    1. NR_033137.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs at the 5' end compared to variant 1, and contains an upstream ORF with a strong Kozak signal, which according to leaky scanning model could interfere with the translation of the downstream primary ORF. Translation from the upstream ORF will render this transcript a candidate for nonsense-mediated mRNA decay (NMD). However, this variant transcript is sufficiently abundant to represent as a non-coding RefSeq record.
      Source sequence(s)
      AK143118, BC052028, CR956641

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      37307060..37326196
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160583.1XP_036016476.1  zinc finger protein 57 isoform X2

      Conserved Domains (4) summary
      smart00349
      Location:1269
      KRAB; krueppel associated box
      COG5048
      Location:136306
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:89131
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:166187
      zf-C2H2; Zinc finger, C2H2 type
    2. XM_036160582.1XP_036016475.1  zinc finger protein 57 isoform X1

      Conserved Domains (4) summary
      smart00349
      Location:1572
      KRAB; krueppel associated box
      COG5048
      Location:139309
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:92134
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:169190
      zf-C2H2; Zinc finger, C2H2 type
    3. XM_036160584.1XP_036016477.1  zinc finger protein 57 isoform X2

      Conserved Domains (4) summary
      smart00349
      Location:1269
      KRAB; krueppel associated box
      COG5048
      Location:136306
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:89131
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:166187
      zf-C2H2; Zinc finger, C2H2 type

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_009559.2: Suppressed sequence

      Description
      NM_009559.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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