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    Eif5b eukaryotic translation initiation factor 5B [ Mus musculus (house mouse) ]

    Gene ID: 226982, updated on 23-Jun-2021

    Summary

    Official Symbol
    Eif5bprovided by MGI
    Official Full Name
    eukaryotic translation initiation factor 5Bprovided by MGI
    Primary source
    MGI:MGI:2441772
    See related
    Ensembl:ENSMUSG00000026083
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IF; IF2; BC018347; A030003E17Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 15.1), liver E14 (RPKM 11.8) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Eif5b in Genome Data Viewer
    Location:
    1; 1 B
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (38037091..38094660)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (37998010..38055579)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (38054855..38112424)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene lysozyme G-like 1 Neighboring gene thioredoxin domain containing 9 Neighboring gene predicted gene, 34448 Neighboring gene REV1, DNA directed polymerase Neighboring gene predicted gene 5099 Neighboring gene AF4/FMR2 family, member 3 Neighboring gene predicted gene 16150

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 5B
    Names
    eIF-5B
    translation initiation factor IF-2
    NP_938045.2
    XP_036020208.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198303.2NP_938045.2  eukaryotic translation initiation factor 5B

      See identical proteins and their annotated locations for NP_938045.2

      Status: VALIDATED

      Source sequence(s)
      AK145732, AK173016, BC103806, CN670500, CN724918
      Consensus CDS
      CCDS35544.1
      UniProtKB/Swiss-Prot
      Q05D44
      UniProtKB/TrEMBL
      Q6A002
      Related
      ENSMUSP00000027252.8, ENSMUST00000027252.8
      Conserved Domains (5) summary
      cd01887
      Location:628841
      IF2_eIF5B; Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family
      PRK04004
      Location:6231198
      PRK04004; translation initiation factor IF-2; Validated
      pfam11987
      Location:9621063
      IF-2; Translation-initiation factor 2
      cd03703
      Location:851961
      aeIF5B_II; Domain II of archaeal and eukaryotic Initiation Factor 5
      cd16266
      Location:10881182
      IF2_aeIF5B_IV; Domain IV of prokaryotic Initiation Factor 2 and archaeal and eukaryotic Initiation Factor 5

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      38037091..38094660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164315.1XP_036020208.1  eukaryotic translation initiation factor 5B isoform X1

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