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    Smg7 SMG7 nonsense mediated mRNA decay factor [ Mus musculus (house mouse) ]

    Gene ID: 226517, updated on 8-Aug-2021

    Summary

    Official Symbol
    Smg7provided by MGI
    Official Full Name
    SMG7 nonsense mediated mRNA decay factorprovided by MGI
    Primary source
    MGI:MGI:2682334
    See related
    Ensembl:ENSMUSG00000042772
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0250; 9430023P16Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 24.5), thymus adult (RPKM 14.9) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Smg7 in Genome Data Viewer
    Location:
    1; 1 G3
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (152712746..152783212, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (152836995..152903130, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (154684125..154749776, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene actin related protein 2/3 complex, subunit 5 Neighboring gene neutrophil cytosolic factor 2 Neighboring gene RIKEN cDNA 1700040K01 gene Neighboring gene ribosomal protein S2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC91209

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein phosphatase 2A binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables telomerase RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of telomerase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    protein SMG7
    Names
    EST1-like protein C
    Smg-7 homolog, nonsense mediated mRNA decay factor
    NP_001005507.1
    NP_001153728.1
    NP_001153729.1
    NP_001346186.1
    XP_006529513.1
    XP_006529514.1
    XP_030109150.1
    XP_030109152.1
    XP_030109154.1
    XP_030109156.1
    XP_030109158.1
    XP_036019885.1
    XP_036019904.1
    XP_036019905.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005507.2NP_001005507.1  protein SMG7 isoform 3

      See identical proteins and their annotated locations for NP_001005507.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and has several differences in the coding sequence compared to variant 1. The resulting isoform (3) has a distinct N-terminus and the protein is shorter compared to isoform 1.
      Source sequence(s)
      AK129101, BC082789, BC086651
      Consensus CDS
      CCDS35740.1
      UniProtKB/Swiss-Prot
      Q5RJH6
      Related
      ENSMUSP00000073144.7, ENSMUST00000073441.13
      Conserved Domains (3) summary
      sd00006
      Location:154180
      TPR; TPR repeat [structural motif]
      pfam10373
      Location:171430
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:55167
      EST1; Telomerase activating protein Est1
    2. NM_001160256.1NP_001153728.1  protein SMG7 isoform 2

      See identical proteins and their annotated locations for NP_001153728.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK129101, BC082789, BC086651
      Consensus CDS
      CCDS48395.1
      UniProtKB/Swiss-Prot
      Q5RJH6
      Related
      ENSMUSP00000107467.3, ENSMUST00000111836.4
      Conserved Domains (3) summary
      sd00006
      Location:154180
      TPR; TPR repeat [structural motif]
      pfam10373
      Location:171430
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:55167
      EST1; Telomerase activating protein Est1
    3. NM_001160257.2NP_001153729.1  protein SMG7 isoform 1

      See identical proteins and their annotated locations for NP_001153729.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest isoform (1).
      Source sequence(s)
      AC110038, AK129101, BC082789
      Consensus CDS
      CCDS48394.1
      UniProtKB/Swiss-Prot
      Q5RJH6
      Related
      ENSMUSP00000041241.9, ENSMUST00000043560.15
      Conserved Domains (3) summary
      sd00006
      Location:162188
      TPR; TPR repeat [structural motif]
      pfam10373
      Location:179438
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:63175
      EST1; Telomerase activating protein Est1
    4. NM_001359257.1NP_001346186.1  protein SMG7 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC110038, AC123613
      Conserved Domains (1) summary
      pfam10373
      Location:195
      EST1_DNA_bind; Est1 DNA/RNA binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      152712746..152783212 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529450.5XP_006529513.1  protein SMG7 isoform X1

      Conserved Domains (3) summary
      sd00006
      Location:162188
      TPR; TPR repeat [structural motif]
      pfam10373
      Location:179438
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:63175
      EST1; Telomerase activating protein Est1
    2. XM_030253294.2XP_030109154.1  protein SMG7 isoform X6

      Conserved Domains (3) summary
      sd00006
      Location:154180
      TPR; TPR repeat [structural motif]
      pfam10373
      Location:171430
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:55167
      EST1; Telomerase activating protein Est1
    3. XM_006529451.5XP_006529514.1  protein SMG7 isoform X2

      Conserved Domains (3) summary
      sd00006
      Location:154180
      TPR; TPR repeat [structural motif]
      pfam10373
      Location:171430
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:55167
      EST1; Telomerase activating protein Est1
    4. XM_030253292.2XP_030109152.1  protein SMG7 isoform X5

      Conserved Domains (3) summary
      sd00006
      Location:162188
      TPR; TPR repeat [structural motif]
      pfam10373
      Location:179438
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:63175
      EST1; Telomerase activating protein Est1
    5. XM_030253290.2XP_030109150.1  protein SMG7 isoform X4

      Conserved Domains (3) summary
      sd00006
      Location:162188
      TPR; TPR repeat [structural motif]
      pfam10373
      Location:179438
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:63175
      EST1; Telomerase activating protein Est1
    6. XM_030253296.2XP_030109156.1  protein SMG7 isoform X7

      Conserved Domains (1) summary
      pfam10373
      Location:195
      EST1_DNA_bind; Est1 DNA/RNA binding domain
    7. XM_036164011.1XP_036019904.1  protein SMG7 isoform X7

      Conserved Domains (1) summary
      pfam10373
      Location:195
      EST1_DNA_bind; Est1 DNA/RNA binding domain
    8. XM_036164012.1XP_036019905.1  protein SMG7 isoform X8

      Conserved Domains (1) summary
      pfam10373
      Location:195
      EST1_DNA_bind; Est1 DNA/RNA binding domain
    9. XM_036163992.1XP_036019885.1  protein SMG7 isoform X3

      Conserved Domains (3) summary
      sd00006
      Location:162188
      TPR; TPR repeat [structural motif]
      pfam10373
      Location:179438
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:63175
      EST1; Telomerase activating protein Est1
    10. XM_030253298.2XP_030109158.1  protein SMG7 isoform X7

      Conserved Domains (1) summary
      pfam10373
      Location:195
      EST1_DNA_bind; Est1 DNA/RNA binding domain
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