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    Rab3gap1 RAB3 GTPase activating protein subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 226407, updated on 9-Sep-2018

    Summary

    Official Symbol
    Rab3gap1provided by MGI
    Official Full Name
    RAB3 GTPase activating protein subunit 1provided by MGI
    Primary source
    MGI:MGI:2445001
    See related
    Ensembl:ENSMUSG00000036104 Vega:OTTMUSG00000025233
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p130; Rab3gap; AL117896; 1700003B17Rik; 4732493F09Rik
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 10.3), cerebellum adult (RPKM 9.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Rab3gap1 in Genome Data Viewer
    Location:
    1; 1 E3
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (127868737..127943876)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (129765350..129840453)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene cyclin T2 Neighboring gene mitogen-activated protein kinase kinase kinase 19 Neighboring gene zinc finger, RAN-binding domain containing 3 Neighboring gene predicted gene 28800 Neighboring gene My020 protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Rab GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to Rab guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    brain development ISO
    Inferred from Sequence Orthology
    more info
     
    camera-type eye development ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of protein localization to endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    excitatory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    face morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    hypothalamus development ISO
    Inferred from Sequence Orthology
    more info
     
    lipid droplet organization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of endoplasmic reticulum tubular network organization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein lipidation ISO
    Inferred from Sequence Orthology
    more info
     
    protein stabilization IC
    Inferred by Curator
    more info
    PubMed 
    regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of calcium ion-dependent exocytosis of neurotransmitter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of short-term neuronal synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of synaptic vesicle priming TAS
    Traceable Author Statement
    more info
    PubMed 
    synaptic vesicle transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum tubular network ISO
    Inferred from Sequence Orthology
    more info
     
    lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    rab3 GTPase-activating protein catalytic subunit
    Names
    RAB3 GTPase-activating protein 130 kDa subunit
    rab3-GAP p130

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178690.4NP_848805.2  rab3 GTPase-activating protein catalytic subunit

      See identical proteins and their annotated locations for NP_848805.2

      Status: VALIDATED

      Source sequence(s)
      AK080432, AK164523, BB755057, CJ084350
      Consensus CDS
      CCDS15249.1
      UniProtKB/Swiss-Prot
      Q80UJ7
      Related
      ENSMUSP00000042070.5, OTTMUSP00000030575, ENSMUST00000037649.5, OTTMUST00000062113
      Conserved Domains (1) summary
      pfam13890
      Location:612769
      Rab3-GTPase_cat; Rab3 GTPase-activating protein catalytic subunit

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      127868737..127943876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529405.2XP_006529468.1  rab3 GTPase-activating protein catalytic subunit isoform X1

      UniProtKB/TrEMBL
      A0A1D5RLG3
      Related
      ENSMUSP00000148357.1, OTTMUSP00000077940, ENSMUST00000212506.1, OTTMUST00000150321
      Conserved Domains (1) summary
      pfam13890
      Location:612769
      Rab3-GTPase_cat; Rab3 GTPase-activating protein catalytic subunit
    2. XM_006529407.3XP_006529470.1  rab3 GTPase-activating protein catalytic subunit isoform X2

      Conserved Domains (1) summary
      pfam13890
      Location:230387
      Rab3-GTPase_cat; Rab3 GTPase-activating protein catalytic subunit

    RNA

    1. XR_001784076.1 RNA Sequence

    2. XR_001784075.1 RNA Sequence

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