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    Epb41l5 erythrocyte membrane protein band 4.1 like 5 [ Mus musculus (house mouse) ]

    Gene ID: 226352, updated on 9-Sep-2018

    Summary

    Official Symbol
    Epb41l5provided by MGI
    Official Full Name
    erythrocyte membrane protein band 4.1 like 5provided by MGI
    Primary source
    MGI:MGI:103006
    See related
    Ensembl:ENSMUSG00000026383 Vega:OTTMUSG00000049017
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BE37; NBL5; Lulu1; AL022914; Epb4.1l5; 1700030C16Rik; E230025E14Rik
    Expression
    Ubiquitous expression in kidney adult (RPKM 3.5), placenta adult (RPKM 3.3) and 26 other tissues See more
    Orthologs

    Genomic context

    See Epb41l5 in Genome Data Viewer
    Location:
    1; 1 E2.3
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (119545032..119649138, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (121441610..121545577, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 3830432H09 gene Neighboring gene transmembrane protein 185B Neighboring gene protein tyrosine phosphatase, non-receptor type 4 Neighboring gene High mobility group protein 1 (HMG-1) (Amphoterin) (Heparin-binding protein p30) Neighboring gene Acidic ribosomal phosphoprotein P0 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    actomyosin structure organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical constriction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axial mesoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axial mesoderm morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell morphogenesis involved in differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to transforming growth factor beta stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ectoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic foregut morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial to mesenchymal transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    left/right axis specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mesoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mesoderm migration involved in gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neural plate morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    paraxial mesoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of epithelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of epithelial to mesenchymal transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of focal adhesion assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    posttranscriptional regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of establishment of protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    somite rostral/caudal axis specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    somitogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    substrate-dependent cell migration, cell attachment to substrate IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    unidimensional cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    adherens junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell leading edge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    band 4.1-like protein 5
    Names
    erythrocyte protein band 4.1-like 5

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113416.1NP_001106887.1  band 4.1-like protein 5 isoform 2

      See identical proteins and their annotated locations for NP_001106887.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate exon in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2) that has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK161141, BY737035
      Consensus CDS
      CCDS48339.1
      UniProtKB/Swiss-Prot
      Q8BGS1
      Related
      ENSMUSP00000140227.1, OTTMUSP00000067933, ENSMUST00000191046.6, OTTMUST00000125207
      Conserved Domains (5) summary
      smart00295
      Location:44235
      B41; Band 4.1 homologues
      cd13186
      Location:231324
      FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
      pfam00373
      Location:128235
      FERM_M; FERM central domain
      pfam08736
      Location:337377
      FA; FERM adjacent (FA)
      pfam09379
      Location:47109
      FERM_N; FERM N-terminal domain
    2. NM_145506.4NP_663481.2  band 4.1-like protein 5 isoform 1

      See identical proteins and their annotated locations for NP_663481.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC132393, AK044959, AK054177, BY737035
      Consensus CDS
      CCDS15226.1
      UniProtKB/Swiss-Prot
      Q8BGS1
      Related
      ENSMUSP00000058966.6, OTTMUSP00000067931, ENSMUST00000052404.12, OTTMUST00000125203
      Conserved Domains (5) summary
      smart00295
      Location:44235
      B41; Band 4.1 homologues
      cd13186
      Location:231324
      FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
      pfam00373
      Location:128235
      FERM_M; FERM central domain
      pfam08736
      Location:337377
      FA; FERM adjacent (FA)
      pfam09379
      Location:47109
      FERM_N; FERM N-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      119545032..119649138 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529399.3XP_006529462.1  band 4.1-like protein 5 isoform X2

      Conserved Domains (5) summary
      smart00295
      Location:44235
      B41; Band 4.1 homologues
      cd13186
      Location:231324
      FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
      pfam00373
      Location:128235
      FERM_M; FERM central domain
      pfam08736
      Location:337377
      FA; FERM adjacent (FA)
      pfam09379
      Location:47109
      FERM_N; FERM N-terminal domain
    2. XM_006529397.1XP_006529460.1  band 4.1-like protein 5 isoform X1

      See identical proteins and their annotated locations for XP_006529460.1

      UniProtKB/Swiss-Prot
      Q8BGS1
      Conserved Domains (5) summary
      smart00295
      Location:44235
      B41; Band 4.1 homologues
      cd13186
      Location:231324
      FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
      pfam00373
      Location:128235
      FERM_M; FERM central domain
      pfam08736
      Location:337377
      FA; FERM adjacent (FA)
      pfam09379
      Location:47109
      FERM_N; FERM N-terminal domain
    3. XM_006529398.1XP_006529461.1  band 4.1-like protein 5 isoform X1

      See identical proteins and their annotated locations for XP_006529461.1

      UniProtKB/Swiss-Prot
      Q8BGS1
      Conserved Domains (5) summary
      smart00295
      Location:44235
      B41; Band 4.1 homologues
      cd13186
      Location:231324
      FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
      pfam00373
      Location:128235
      FERM_M; FERM central domain
      pfam08736
      Location:337377
      FA; FERM adjacent (FA)
      pfam09379
      Location:47109
      FERM_N; FERM N-terminal domain
    4. XM_006529400.1XP_006529463.1  band 4.1-like protein 5 isoform X3

      See identical proteins and their annotated locations for XP_006529463.1

      UniProtKB/Swiss-Prot
      Q8BGS1
      Related
      ENSMUSP00000027632.7, OTTMUSP00000067934, ENSMUST00000027632.13, OTTMUST00000125208
      Conserved Domains (5) summary
      smart00295
      Location:44235
      B41; Band 4.1 homologues
      cd13186
      Location:231324
      FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
      pfam00373
      Location:128235
      FERM_M; FERM central domain
      pfam08736
      Location:337377
      FA; FERM adjacent (FA)
      pfam09379
      Location:47109
      FERM_N; FERM N-terminal domain
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