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    FGFR3 fibroblast growth factor receptor 3 [ Homo sapiens (human) ]

    Gene ID: 2261, updated on 20-Jun-2021

    Summary

    Official Symbol
    FGFR3provided by HGNC
    Official Full Name
    fibroblast growth factor receptor 3provided by HGNC
    Primary source
    HGNC:HGNC:3690
    See related
    Ensembl:ENSG00000068078 MIM:134934
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACH; CEK2; JTK4; CD333; HSFGFR3EX
    Summary
    This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. [provided by RefSeq, Aug 2017]
    Expression
    Biased expression in skin (RPKM 120.7), esophagus (RPKM 18.0) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FGFR3 in Genome Data Viewer
    Location:
    4p16.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (1793293..1808872)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (1795020..1810594)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene transforming acidic coiled-coil containing protein 3 Neighboring gene uncharacterized LOC112268460 Neighboring gene CRISPRi-validated cis-regulatory element chr4.260 Neighboring gene leucine zipper and EF-hand containing transmembrane protein 1 Neighboring gene RNA, 7SL, cytoplasmic 671, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.
    GeneReviews: Not available
    A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer.
    GeneReviews: Not available
    Achondroplasia
    MedGen: C0001080 OMIM: 100800 GeneReviews: Achondroplasia
    Compare labs
    Camptodactyly-tall stature-scoliosis-hearing loss syndrome
    MedGen: C1864852 OMIM: 610474 GeneReviews: Not available
    Compare labs
    Cancer of cervix
    MedGen: C4048328 OMIM: 603956 GeneReviews: Not available
    Compare labs
    Colorectal cancer
    MedGen: C0009402 OMIM: 114500 GeneReviews: Lynch Syndrome
    Compare labs
    Crouzon syndrome with acanthosis nigricans Compare labs
    Epidermal nevus
    MedGen: C0334082 OMIM: 162900 GeneReviews: Not available
    Compare labs
    Genome-wide association study identifies multiple loci associated with bladder cancer risk.
    GeneReviews: Not available
    Germ cell tumor of testis
    MedGen: C1336708 OMIM: 273300 GeneReviews: Not available
    Compare labs
    Hypochondroplasia
    MedGen: C0410529 OMIM: 146000 GeneReviews: Hypochondroplasia
    Compare labs
    Isolated coronal synostosis Compare labs
    Levy-Hollister syndrome
    MedGen: C0265269 OMIM: 149730 GeneReviews: Not available
    Compare labs
    Muenke syndrome Compare labs
    Severe achondroplasia with developmental delay and acanthosis nigricans
    MedGen: C2674173 OMIM: 616482 GeneReviews: Not available
    Compare labs
    Thanatophoric dysplasia type 1
    MedGen: C1868678 OMIM: 187600 GeneReviews: Thanatophoric Dysplasia
    Compare labs
    Thanatophoric dysplasia, type 2
    MedGen: C1300257 OMIM: 187601 GeneReviews: Thanatophoric Dysplasia
    Compare labs
    Urinary bladder cancer
    MedGen: C0005684 OMIM: 109800 GeneReviews: Not available
    Compare labs

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2011-11-09)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2011-11-09)

    ClinGen Genome Curation PagePubMed

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables fibroblast growth factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables fibroblast growth factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables fibroblast growth factor-activated receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables fibroblast growth factor-activated receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in MAPK cascade TAS
    Traceable Author Statement
    more info
     
    involved_in bone maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in bone mineralization ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in bone morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in bone morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell-cell signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chondrocyte differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in chondrocyte proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in endochondral bone growth TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in endochondral ossification TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in fibroblast growth factor receptor apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fibroblast growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in fibroblast growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of developmental growth ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of phospholipase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein kinase B signaling TAS
    Traceable Author Statement
    more info
     
    involved_in positive regulation of tyrosine phosphorylation of STAT protein IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in skeletal system development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with focal adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in transport vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    fibroblast growth factor receptor 3
    Names
    FGFR-3
    fibroblast growth factor receptor 3 variant 4
    fibroblast growth factor receptor 3-S
    hydroxyaryl-protein kinase
    tyrosine kinase JTK4
    NP_000133.1
    NP_001156685.1
    NP_001341738.1
    NP_001341739.1
    NP_075254.1
    XP_006713931.1
    XP_006713932.1
    XP_006713933.1
    XP_006713934.1
    XP_006713936.1
    XP_011511722.1
    XP_011511724.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012632.1 RefSeqGene

      Range
      5001..20561
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1021

    mRNA and Protein(s)

    1. NM_000142.5NP_000133.1  fibroblast growth factor receptor 3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_000133.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks an alternate coding exon and contains another alternate coding exon compared to variant 3. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 3.
      Source sequence(s)
      AC016773
      Consensus CDS
      CCDS3353.1
      UniProtKB/Swiss-Prot
      P22607
      UniProtKB/TrEMBL
      Q0IJ44
      Related
      ENSP00000414914.2, ENST00000440486.8
      Conserved Domains (7) summary
      cd05857
      Location:161245
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:268357
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      smart00408
      Location:53110
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:54125
      IG; Immunoglobulin
      smart00410
      Location:260356
      IG_like; Immunoglobulin like
      pfam07714
      Location:472748
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:459792
      PKc_like; Protein Kinases, catalytic domain
    2. NM_001163213.2NP_001156685.1  fibroblast growth factor receptor 3 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001156685.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), also known as isoform IIIb, encodes the longest isoform (3).
      Source sequence(s)
      AC016773
      Consensus CDS
      CCDS54706.1
      UniProtKB/Swiss-Prot
      P22607
      UniProtKB/TrEMBL
      Q0IJ44
      Related
      ENSP00000339824.4, ENST00000340107.8
      Conserved Domains (7) summary
      cd04974
      Location:268356
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:161245
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      smart00408
      Location:53110
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:54125
      IG; Immunoglobulin
      smart00410
      Location:260355
      IG_like; Immunoglobulin like
      pfam07714
      Location:474750
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:461794
      PKc_like; Protein Kinases, catalytic domain
    3. NM_001354809.2NP_001341738.1  fibroblast growth factor receptor 3 isoform 4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate coding exon, contains another alternate coding exon, and uses an alternate in-frame splice junction compared to variant 3. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 3.
      Source sequence(s)
      AC016773
      Conserved Domains (4) summary
      cd05857
      Location:161245
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:268357
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      smart00408
      Location:53110
      IGc2; Immunoglobulin C-2 Type
      cl21453
      Location:460793
      PKc_like; Protein Kinases, catalytic domain
    4. NM_001354810.2NP_001341739.1  fibroblast growth factor receptor 3 isoform 5 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two alternate coding exons, contains another alternate coding exon, and uses an alternate in-frame splice junction compared to variant 3. The resulting isoform (5) has multiple differences compared to isoform 3.
      Source sequence(s)
      AC016773
      Consensus CDS
      CCDS87200.1
      Related
      ENSP00000420533.2, ENST00000481110.7
      Conserved Domains (4) summary
      cd05857
      Location:161245
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:268357
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      smart00408
      Location:53110
      IGc2; Immunoglobulin C-2 Type
      cl21453
      Location:460654
      PKc_like; Protein Kinases, catalytic domain
    5. NM_022965.4NP_075254.1  fibroblast growth factor receptor 3 isoform 2 precursor

      See identical proteins and their annotated locations for NP_075254.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two alternate coding exons compared to variant 3. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 3.
      Source sequence(s)
      AC016773
      Consensus CDS
      CCDS3354.1
      UniProtKB/Swiss-Prot
      P22607
      UniProtKB/TrEMBL
      Q0IJ44
      Related
      ENSP00000231803.1, ENST00000352904.6
      Conserved Domains (6) summary
      cd04974
      Location:268357
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:161245
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      smart00408
      Location:53110
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:260289
      IG; Immunoglobulin
      pfam07714
      Location:360636
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:347680
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. NR_148971.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) contains an alternate exon compared to variant 3. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC016773

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

      Range
      1793293..1808872
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006713868.1XP_006713931.1  fibroblast growth factor receptor 3 isoform X1

      Conserved Domains (7) summary
      cd04974
      Location:268356
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:161245
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      smart00408
      Location:53110
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:54125
      IG; Immunoglobulin
      smart00410
      Location:260355
      IG_like; Immunoglobulin like
      pfam07714
      Location:476752
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:463797
      PKc_like; Protein Kinases, catalytic domain
    2. XM_006713869.1XP_006713932.1  fibroblast growth factor receptor 3 isoform X2

      Conserved Domains (7) summary
      cd04974
      Location:268356
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:161245
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      smart00408
      Location:53110
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:54125
      IG; Immunoglobulin
      smart00410
      Location:260355
      IG_like; Immunoglobulin like
      pfam07714
      Location:476752
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:463796
      PKc_like; Protein Kinases, catalytic domain
    3. XM_006713870.1XP_006713933.1  fibroblast growth factor receptor 3 isoform X3

      Conserved Domains (7) summary
      cd04974
      Location:268356
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:161245
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      smart00408
      Location:53110
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:54125
      IG; Immunoglobulin
      smart00410
      Location:260355
      IG_like; Immunoglobulin like
      pfam07714
      Location:475751
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:462796
      PKc_like; Protein Kinases, catalytic domain
    4. XM_006713871.1XP_006713934.1  fibroblast growth factor receptor 3 isoform X4

      Conserved Domains (7) summary
      cd04974
      Location:268356
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:161245
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      smart00408
      Location:53110
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:54125
      IG; Immunoglobulin
      smart00410
      Location:260355
      IG_like; Immunoglobulin like
      pfam07714
      Location:474750
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:461795
      PKc_like; Protein Kinases, catalytic domain
    5. XM_011513420.1XP_011511722.1  fibroblast growth factor receptor 3 isoform X5

      Conserved Domains (7) summary
      cd05857
      Location:161245
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:268357
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      smart00408
      Location:53110
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:54125
      IG; Immunoglobulin
      smart00410
      Location:260356
      IG_like; Immunoglobulin like
      pfam07714
      Location:474750
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:461795
      PKc_like; Protein Kinases, catalytic domain
    6. XM_011513422.1XP_011511724.1  fibroblast growth factor receptor 3 isoform X6

      Conserved Domains (7) summary
      cd05857
      Location:161245
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:268357
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      smart00408
      Location:53110
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:54125
      IG; Immunoglobulin
      smart00410
      Location:260356
      IG_like; Immunoglobulin like
      pfam07714
      Location:473749
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:460794
      PKc_like; Protein Kinases, catalytic domain
    7. XM_006713873.1XP_006713936.1  fibroblast growth factor receptor 3 isoform X7

      Conserved Domains (7) summary
      cd05857
      Location:161245
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:268357
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      smart00408
      Location:53110
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:54125
      IG; Immunoglobulin
      smart00410
      Location:260356
      IG_like; Immunoglobulin like
      pfam07714
      Location:472748
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:459793
      PKc_like; Protein Kinases, catalytic domain
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