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    Ybx1 Y box protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 22608, updated on 6-Nov-2018

    Summary

    Official Symbol
    Ybx1provided by MGI
    Official Full Name
    Y box protein 1provided by MGI
    Primary source
    MGI:MGI:99146
    See related
    Ensembl:ENSMUSG00000028639 Vega:OTTMUSG00000009259
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EF1A; MSY1; YB-1; dbpB; Nsep1; C79409; mYB-1a; 1700102N10Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 192.5), CNS E11.5 (RPKM 174.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ybx1 in Genome Data Viewer
    Location:
    4; 4 D2.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (119277327..119294666, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (118949932..118967118, complement)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene prolyl 3-hydroxylase 1 Neighboring gene predicted gene 12927 Neighboring gene claudin 19 Neighboring gene peptidyl prolyl isomerase H Neighboring gene coiled-coil domain containing 30 Neighboring gene lactate dehydrogenase A, pseudogene 2

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC118070

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    CRD-mediated mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    in utero embryonic development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of striated muscle cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    CRD-mediated mRNA stability complex ISO
    Inferred from Sequence Orthology
    more info
     
    U12-type spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    histone pre-mRNA 3'end processing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    messenger ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    nuclease-sensitive element-binding protein 1
    Names
    CBF-A
    CCAAT-binding transcription factor I subunit A
    DNA-binding protein B
    EFI-A
    Y-box transcription factor
    Y-box-binding protein 1
    enhancer factor I subunit A

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011732.2NP_035862.2  nuclease-sensitive element-binding protein 1

      See identical proteins and their annotated locations for NP_035862.2

      Status: VALIDATED

      Source sequence(s)
      AK150821, BG066506, BU512458, BX470153
      Consensus CDS
      CCDS18579.1
      UniProtKB/Swiss-Prot
      P62960
      UniProtKB/TrEMBL
      Q3UBT1
      Related
      ENSMUSP00000078589.6, OTTMUSP00000009615, ENSMUST00000079644.12, OTTMUST00000020973
      Conserved Domains (1) summary
      pfam00313
      Location:57126
      CSD; 'Cold-shock' DNA-binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      119277327..119294666 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502934.3XP_006502997.1  nuclease-sensitive element-binding protein 1 isoform X2

      Conserved Domains (1) summary
      cd04458
      Location:5988
      CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...
    2. XM_006502933.3XP_006502996.1  nuclease-sensitive element-binding protein 1 isoform X1

      Conserved Domains (1) summary
      pfam00313
      Location:57126
      CSD; 'Cold-shock' DNA-binding domain
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