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    Ubxn1 UBX domain protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 225896, updated on 26-Sep-2022

    Summary

    Official Symbol
    Ubxn1provided by MGI
    Official Full Name
    UBX domain protein 1provided by MGI
    Primary source
    MGI:MGI:1289301
    See related
    Ensembl:ENSMUSG00000071655 AllianceGenome:MGI:1289301
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2B28; mY33K; D19Ertd721e; 4930455J02Rik
    Summary
    Predicted to enable several functions, including enzyme binding activity; polyubiquitin modification-dependent protein binding activity; and proteasome regulatory particle binding activity. Predicted to be involved in negative regulation of cellular protein metabolic process. Predicted to be located in several cellular components, including dendrite; neuronal cell body; and nucleoplasm. Predicted to be part of VCP-NPL4-UFD1 AAA ATPase complex. Is expressed in pancreas epithelium. Orthologous to human UBXN1 (UBX domain protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 89.4), CNS E11.5 (RPKM 86.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ubxn1 in Genome Data Viewer
    Location:
    19; 19 A
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8848912..8853030)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8871548..8875666)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene Berardinelli-Seip congenital lipodystrophy 2 (seipin) Neighboring gene guanine nucleotide binding protein (G protein), gamma 3 Neighboring gene LRRN4 C-terminal like Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 3 Neighboring gene RIKEN cDNA 5730408K05 gene Neighboring gene LBH domain containing 1 Neighboring gene small nucleolar RNA, H/ACA box 57

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC6696

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    part_of VCP-NPL4-UFD1 AAA ATPase complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    UBX domain-containing protein 1
    Names
    SAPK substrate protein 1
    UBA/UBX 33.3 kDa protein
    protein 2B28

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362044.1NP_001348973.1  UBX domain-containing protein 1

      Status: VALIDATED

      Source sequence(s)
      AK150442, BY238872, BY606648, CX123666
      Consensus CDS
      CCDS29553.1
      UniProtKB/Swiss-Prot
      Q3UCP8
      UniProtKB/TrEMBL
      A0A6P5P4W7
      Related
      ENSMUSP00000157971.2, ENSMUST00000238036.2
      Conserved Domains (2) summary
      cd01772
      Location:210293
      SAKS1_UBX; SAKS1-like UBX domain
      cd14302
      Location:545
      UBA_UBXN1; UBA domain found in UBX domain-containing protein 1 (UBXN1) and similar proteins
    2. NM_146093.2NP_666205.1  UBX domain-containing protein 1

      See identical proteins and their annotated locations for NP_666205.1

      Status: VALIDATED

      Source sequence(s)
      AC129217
      Consensus CDS
      CCDS29553.1
      UniProtKB/Swiss-Prot
      Q3UCP8, Q922Y1
      UniProtKB/TrEMBL
      A0A6P5P4W7
      Related
      ENSMUSP00000133250.2, ENSMUST00000166407.9
      Conserved Domains (2) summary
      cd01772
      Location:210293
      SAKS1_UBX; SAKS1-like UBX domain
      cd14302
      Location:545
      UBA_UBXN1; UBA domain found in UBX domain-containing protein 1 (UBXN1) and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      8848912..8853030
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)