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    Atrx ATRX, chromatin remodeler [ Mus musculus (house mouse) ]

    Gene ID: 22589, updated on 6-Sep-2021

    Summary

    Official Symbol
    Atrxprovided by MGI
    Official Full Name
    ATRX, chromatin remodelerprovided by MGI
    Primary source
    MGI:MGI:103067
    See related
    Ensembl:ENSMUSG00000031229
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    X; Rad; XH2; Xnp; ATR2; Hp1b; MRXS3; Rad54; HP1-BP; Hp1bp2; RAD54L; ZNF-HX; Hp1bp38; AI447451; HP1-BP38; DXHXS6677; DXHXS6677E; 4833408C14Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 17.4), CNS E14 (RPKM 16.1) and 23 other tissues See more
    Orthologs
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    Genomic context

    See Atrx in Genome Data Viewer
    Location:
    X D; X 47.26 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (104841221..104972978, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (105797615..105929372, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (102992954..103124711, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L12 pseudogene Neighboring gene fibroblast growth factor 16 Neighboring gene predicted gene, 26020 Neighboring gene ribosomal protein 17a pseudogene Neighboring gene predicted gene, 23656 Neighboring gene magnesium transporter 1 Neighboring gene cytochrome c oxidase subunit 7B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA translocase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromo shadow domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response, signal transduction by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA replication-independent nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within Sertoli cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hydroxyurea IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within chromosome organization involved in meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within meiotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of telomeric RNA transcription from RNA pol II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nuclear cell cycle DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of telomeric RNA transcription from RNA pol II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within post-embryonic forelimb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to chromosome, telomeric region IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of histone H3-K9 trimethylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in replication fork processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within seminiferous tubule development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, subtelomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in condensed chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    transcriptional regulator ATRX
    Names
    ATP-dependent helicase ATRX
    HP1 alpha-interacting protein
    X-linked nuclear protein
    alpha thalassemia/mental retardation syndrome X-linked homolog
    heterochromatin protein 2
    NP_033556.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009530.2NP_033556.2  transcriptional regulator ATRX

      See identical proteins and their annotated locations for NP_033556.2

      Status: VALIDATED

      Source sequence(s)
      AL670660, AL671893
      Consensus CDS
      CCDS41095.1
      UniProtKB/Swiss-Prot
      Q61687
      Related
      ENSMUSP00000109203.2, ENSMUST00000113573.8
      Conserved Domains (6) summary
      cd00046
      Location:15731735
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:20002146
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd11726
      Location:166269
      ADDz_ATRX; ADDz domain found in ATRX (alpha-thalassemia/mental retardation, X-linked)
      pfam00176
      Location:15481874
      SNF2_N; SNF2 family N-terminal domain
      pfam08070
      Location:727820
      DTHCT; DTHCT (NUC029) region
      pfam15917
      Location:9141004
      PIEZO; Piezo

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      104841221..104972978 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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