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    Atrx ATRX, chromatin remodeler [ Mus musculus (house mouse) ]

    Gene ID: 22589, updated on 5-Mar-2019

    Summary

    Official Symbol
    Atrxprovided by MGI
    Official Full Name
    ATRX, chromatin remodelerprovided by MGI
    Primary source
    MGI:MGI:103067
    See related
    Ensembl:ENSMUSG00000031229
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    XH2; Xnp; ATR2; MRXS3; Rad54; Hp1bp2; RAD54L; ZNF-HX; Hp1bp38; AI447451; HP1-BP38; DXHXS6677E; 4833408C14Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 17.4), CNS E14 (RPKM 16.1) and 23 other tissues See more
    Orthologs

    Genomic context

    See Atrx in Genome Data Viewer
    Location:
    X D; X 47.26 cM
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (105797615..105929406, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (102992954..103124711, complement)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L12 pseudogene Neighboring gene fibroblast growth factor 16 Neighboring gene predicted gene 14853 Neighboring gene magnesium transporter 1 Neighboring gene cytochrome c oxidase subunit 7B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • PluriNetWork, organism-specific biosystem (from WikiPathways)
      PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA translocase activity ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromo shadow domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA damage response, signal transduction by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    DNA replication-independent nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Sertoli cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to hydroxyurea IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome organization involved in meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    meiotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of telomeric RNA transcription from RNA pol II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of nuclear cell cycle DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of telomeric RNA transcription from RNA pol II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    post-embryonic forelimb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to chromosome, telomeric region IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of histone H3-K9 trimethylation ISO
    Inferred from Sequence Orthology
    more info
     
    replication fork processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    seminiferous tubule development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
     
    condensed nuclear chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with nuclear chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear subtelomeric heterochromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    telomeric heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    transcriptional regulator ATRX
    Names
    ATP-dependent helicase ATRX
    HP1 alpha-interacting protein
    X-linked nuclear protein
    alpha thalassemia/mental retardation syndrome X-linked homolog
    heterochromatin protein 2
    NP_033556.2
    XP_006528011.1
    XP_011245862.1
    XP_011245863.1
    XP_011245864.1
    XP_011245865.1
    XP_011245866.1
    XP_011245867.1
    XP_011245868.1
    XP_011245869.1
    XP_011245870.1
    XP_011245871.1
    XP_011245872.1
    XP_011245873.1
    XP_011245874.1
    XP_011245875.1
    XP_011245876.1
    XP_011245877.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009530.2NP_033556.2  transcriptional regulator ATRX

      See identical proteins and their annotated locations for NP_033556.2

      Status: VALIDATED

      Source sequence(s)
      AL670660, AL671893
      Consensus CDS
      CCDS41095.1
      UniProtKB/Swiss-Prot
      Q61687
      Related
      ENSMUSP00000109203.1, ENSMUST00000113573.7
      Conserved Domains (6) summary
      cd00046
      Location:15731735
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:20002146
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd11726
      Location:166269
      ADDz_ATRX; ADDz domain found in ATRX (alpha-thalassemia/mental retardation, X-linked)
      pfam00176
      Location:15481874
      SNF2_N; SNF2 family N-terminal domain
      pfam08070
      Location:727820
      DTHCT; DTHCT (NUC029) region
      pfam15917
      Location:9141004
      PIEZO; Piezo

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      105797615..105929406 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247569.2XP_011245871.1  transcriptional regulator ATRX isoform X8

      See identical proteins and their annotated locations for XP_011245871.1

      Conserved Domains (6) summary
      cd00046
      Location:15181680
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:19482094
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd11726
      Location:111214
      ADDz_ATRX; ADDz domain found in ATRX (alpha-thalassemia/mental retardation, X-linked)
      pfam00176
      Location:14931819
      SNF2_N; SNF2 family N-terminal domain
      pfam08070
      Location:672765
      DTHCT; DTHCT (NUC029) region
      pfam15917
      Location:859949
      PIEZO; Piezo
    2. XM_011247562.2XP_011245864.1  transcriptional regulator ATRX isoform X4

      Conserved Domains (6) summary
      cd00046
      Location:15731735
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:20032149
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd11726
      Location:166269
      ADDz_ATRX; ADDz domain found in ATRX (alpha-thalassemia/mental retardation, X-linked)
      pfam00176
      Location:15481874
      SNF2_N; SNF2 family N-terminal domain
      pfam08070
      Location:727820
      DTHCT; DTHCT (NUC029) region
      pfam15917
      Location:9141004
      PIEZO; Piezo
    3. XM_011247568.2XP_011245870.1  transcriptional regulator ATRX isoform X7

      See identical proteins and their annotated locations for XP_011245870.1

      Conserved Domains (6) summary
      cd00046
      Location:15341696
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:19642110
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd11726
      Location:127230
      ADDz_ATRX; ADDz domain found in ATRX (alpha-thalassemia/mental retardation, X-linked)
      pfam00176
      Location:15091835
      SNF2_N; SNF2 family N-terminal domain
      pfam08070
      Location:688781
      DTHCT; DTHCT (NUC029) region
      pfam15917
      Location:875965
      PIEZO; Piezo
    4. XM_011247571.2XP_011245873.1  transcriptional regulator ATRX isoform X10

      Conserved Domains (6) summary
      cd00046
      Location:14801642
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:19102056
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd11726
      Location:73176
      ADDz_ATRX; ADDz domain found in ATRX (alpha-thalassemia/mental retardation, X-linked)
      pfam00176
      Location:14551781
      SNF2_N; SNF2 family N-terminal domain
      pfam08070
      Location:634727
      DTHCT; DTHCT (NUC029) region
      pfam15917
      Location:821911
      PIEZO; Piezo
    5. XM_011247572.2XP_011245874.1  transcriptional regulator ATRX isoform X8

      See identical proteins and their annotated locations for XP_011245874.1

      Conserved Domains (6) summary
      cd00046
      Location:15181680
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:19482094
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd11726
      Location:111214
      ADDz_ATRX; ADDz domain found in ATRX (alpha-thalassemia/mental retardation, X-linked)
      pfam00176
      Location:14931819
      SNF2_N; SNF2 family N-terminal domain
      pfam08070
      Location:672765
      DTHCT; DTHCT (NUC029) region
      pfam15917
      Location:859949
      PIEZO; Piezo
    6. XM_011247567.2XP_011245869.1  transcriptional regulator ATRX isoform X7

      See identical proteins and their annotated locations for XP_011245869.1

      Conserved Domains (6) summary
      cd00046
      Location:15341696
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:19642110
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd11726
      Location:127230
      ADDz_ATRX; ADDz domain found in ATRX (alpha-thalassemia/mental retardation, X-linked)
      pfam00176
      Location:15091835
      SNF2_N; SNF2 family N-terminal domain
      pfam08070
      Location:688781
      DTHCT; DTHCT (NUC029) region
      pfam15917
      Location:875965
      PIEZO; Piezo
    7. XM_011247570.2XP_011245872.1  transcriptional regulator ATRX isoform X9

      Conserved Domains (6) summary
      cd00046
      Location:14961658
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:19262072
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd11726
      Location:89192
      ADDz_ATRX; ADDz domain found in ATRX (alpha-thalassemia/mental retardation, X-linked)
      pfam00176
      Location:14711797
      SNF2_N; SNF2 family N-terminal domain
      pfam08070
      Location:650743
      DTHCT; DTHCT (NUC029) region
      pfam15917
      Location:837927
      PIEZO; Piezo
    8. XM_011247565.2XP_011245867.1  transcriptional regulator ATRX isoform X7

      See identical proteins and their annotated locations for XP_011245867.1

      Conserved Domains (6) summary
      cd00046
      Location:15341696
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:19642110
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd11726
      Location:127230
      ADDz_ATRX; ADDz domain found in ATRX (alpha-thalassemia/mental retardation, X-linked)
      pfam00176
      Location:15091835
      SNF2_N; SNF2 family N-terminal domain
      pfam08070
      Location:688781
      DTHCT; DTHCT (NUC029) region
      pfam15917
      Location:875965
      PIEZO; Piezo
    9. XM_011247566.2XP_011245868.1  transcriptional regulator ATRX isoform X7

      See identical proteins and their annotated locations for XP_011245868.1

      Conserved Domains (6) summary
      cd00046
      Location:15341696
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:19642110
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd11726
      Location:127230
      ADDz_ATRX; ADDz domain found in ATRX (alpha-thalassemia/mental retardation, X-linked)
      pfam00176
      Location:15091835
      SNF2_N; SNF2 family N-terminal domain
      pfam08070
      Location:688781
      DTHCT; DTHCT (NUC029) region
      pfam15917
      Location:875965
      PIEZO; Piezo
    10. XM_011247561.1XP_011245863.1  transcriptional regulator ATRX isoform X2

      Conserved Domains (6) summary
      cd00046
      Location:15871749
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:20172163
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd11726
      Location:180283
      ADDz_ATRX; ADDz domain found in ATRX (alpha-thalassemia/mental retardation, X-linked)
      pfam00176
      Location:15621888
      SNF2_N; SNF2 family N-terminal domain
      pfam08070
      Location:741834
      DTHCT; DTHCT (NUC029) region
      pfam15917
      Location:9281018
      PIEZO; Piezo
    11. XM_006527948.2XP_006528011.1  transcriptional regulator ATRX isoform X3

      Conserved Domains (6) summary
      cd00046
      Location:15881750
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:20152161
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd11726
      Location:181284
      ADDz_ATRX; ADDz domain found in ATRX (alpha-thalassemia/mental retardation, X-linked)
      pfam00176
      Location:15631889
      SNF2_N; SNF2 family N-terminal domain
      pfam08070
      Location:742835
      DTHCT; DTHCT (NUC029) region
      pfam15917
      Location:9291019
      PIEZO; Piezo
    12. XM_011247560.1XP_011245862.1  transcriptional regulator ATRX isoform X1

      Conserved Domains (6) summary
      cd00046
      Location:15881750
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:20182164
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd11726
      Location:181284
      ADDz_ATRX; ADDz domain found in ATRX (alpha-thalassemia/mental retardation, X-linked)
      pfam00176
      Location:15631889
      SNF2_N; SNF2 family N-terminal domain
      pfam08070
      Location:742835
      DTHCT; DTHCT (NUC029) region
      pfam15917
      Location:9291019
      PIEZO; Piezo
    13. XM_011247564.1XP_011245866.1  transcriptional regulator ATRX isoform X6

      Conserved Domains (6) summary
      cd00046
      Location:15491711
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:19792125
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd11726
      Location:142245
      ADDz_ATRX; ADDz domain found in ATRX (alpha-thalassemia/mental retardation, X-linked)
      pfam00176
      Location:15241850
      SNF2_N; SNF2 family N-terminal domain
      pfam08070
      Location:703796
      DTHCT; DTHCT (NUC029) region
      pfam15917
      Location:890980
      PIEZO; Piezo
    14. XM_011247563.1XP_011245865.1  transcriptional regulator ATRX isoform X5

      Conserved Domains (6) summary
      cd00046
      Location:15501712
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00079
      Location:19802126
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd11726
      Location:143246
      ADDz_ATRX; ADDz domain found in ATRX (alpha-thalassemia/mental retardation, X-linked)
      pfam00176
      Location:15251851
      SNF2_N; SNF2 family N-terminal domain
      pfam08070
      Location:704797
      DTHCT; DTHCT (NUC029) region
      pfam15917
      Location:891981
      PIEZO; Piezo
    15. XM_011247573.2XP_011245875.1  transcriptional regulator ATRX isoform X11

      Conserved Domains (4) summary
      cd00046
      Location:15881750
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd11726
      Location:181284
      ADDz_ATRX; ADDz domain found in ATRX (alpha-thalassemia/mental retardation, X-linked)
      pfam00176
      Location:15631889
      SNF2_N; SNF2 family N-terminal domain
      pfam15917
      Location:9291019
      PIEZO; Piezo
    16. XM_011247575.2XP_011245877.1  transcriptional regulator ATRX isoform X13

      Conserved Domains (4) summary
      cd00046
      Location:15881750
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd11726
      Location:181284
      ADDz_ATRX; ADDz domain found in ATRX (alpha-thalassemia/mental retardation, X-linked)
      pfam00176
      Location:15631889
      SNF2_N; SNF2 family N-terminal domain
      pfam15917
      Location:9291019
      PIEZO; Piezo
    17. XM_011247574.2XP_011245876.1  transcriptional regulator ATRX isoform X12

      Conserved Domains (4) summary
      cd00046
      Location:15881750
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd11726
      Location:181284
      ADDz_ATRX; ADDz domain found in ATRX (alpha-thalassemia/mental retardation, X-linked)
      pfam00176
      Location:15631889
      SNF2_N; SNF2 family N-terminal domain
      pfam15917
      Location:9291019
      PIEZO; Piezo

    RNA

    1. XR_001782745.1 RNA Sequence

    2. XR_878099.2 RNA Sequence

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