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    MAPK15 mitogen-activated protein kinase 15 [ Homo sapiens (human) ]

    Gene ID: 225689, updated on 17-Jun-2024

    Summary

    Official Symbol
    MAPK15provided by HGNC
    Official Full Name
    mitogen-activated protein kinase 15provided by HGNC
    Primary source
    HGNC:HGNC:24667
    See related
    Ensembl:ENSG00000181085 MIM:618616; AllianceGenome:HGNC:24667
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ERK7; ERK8
    Summary
    Enables MAP kinase activity and chromatin binding activity. Involved in several processes, including dopamine uptake; positive regulation of DNA metabolic process; and regulation of organelle organization. Located in several cellular components, including Golgi apparatus; autophagosome; and microtubule organizing center. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in lung (RPKM 5.3), testis (RPKM 4.6) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MAPK15 in Genome Data Viewer
    Location:
    8q24.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (143716349..143722458)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (144872787..144878895)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (144798519..144804628)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144781964-144782464 Neighboring gene long intergenic non-protein coding RNA 2878 Neighboring gene uncharacterized LOC101928160 Neighboring gene coiled-coil domain containing 166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144805293-144805794 Neighboring gene family with sequence similarity 83 member H Neighboring gene Sharpr-MPRA regulatory region 4007 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144819935-144820800 Neighboring gene microRNA 4664 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144822529-144823392 Neighboring gene IQ motif and ankyrin repeat containing 1 Neighboring gene SREBF pathway regulator in golgi 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 binding to CD4 results in activation of the mitogen-activated protein kinase (MAPK) in CD4(+) lymphocytes prestimulated through their T-cell receptor (TCR) PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables SH3 domain binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dopamine uptake IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in endoplasmic reticulum organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of metaphase/anaphase transition of meiosis I IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of spindle assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of telomerase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of telomerase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of telomere capping IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of telomere capping IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of telomere maintenance via telomerase IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of telomere maintenance via telomerase IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein localization to ciliary transition zone IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of COPII vesicle coating IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of autophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in autophagosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT located_in axoneme IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in meiotic spindle IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    mitogen-activated protein kinase 15
    Names
    ERK-7
    ERK-8
    MAP kinase 15
    MAPK 15
    extracellular regulated kinase 8 delta
    extracellular signal-regulated kinase 7
    extracellular signal-regulated kinase 8
    NP_620590.2
    XP_011515227.1
    XP_011515228.1
    XP_011515229.1
    XP_011515230.1
    XP_047277522.1
    XP_047277523.1
    XP_047277524.1
    XP_054184724.1
    XP_054184725.1
    XP_054184726.1
    XP_054184727.1
    XP_054184728.1
    XP_054184729.1
    XP_054184730.1
    XP_054216067.1
    XP_054216068.1
    XP_054216069.1
    XP_054216070.1
    XP_054216071.1
    XP_054216072.1
    XP_054216073.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139021.3NP_620590.2  mitogen-activated protein kinase 15

      See identical proteins and their annotated locations for NP_620590.2

      Status: VALIDATED

      Source sequence(s)
      AY065978, BP357805
      Consensus CDS
      CCDS6409.2
      UniProtKB/Swiss-Prot
      Q2TCF9, Q8N362, Q8TD08
      Related
      ENSP00000337691.4, ENST00000338033.9
      Conserved Domains (2) summary
      smart00220
      Location:13304
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07852
      Location:5343
      STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      143716349..143722458
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011516926.3XP_011515228.1  mitogen-activated protein kinase 15 isoform X2

      See identical proteins and their annotated locations for XP_011515228.1

      Conserved Domains (2) summary
      smart00220
      Location:13323
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07852
      Location:5362
      STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs
    2. XM_047421567.1XP_047277523.1  mitogen-activated protein kinase 15 isoform X5

    3. XM_047421568.1XP_047277524.1  mitogen-activated protein kinase 15 isoform X6

    4. XM_011516925.3XP_011515227.1  mitogen-activated protein kinase 15 isoform X1

      See identical proteins and their annotated locations for XP_011515227.1

      Conserved Domains (2) summary
      smart00220
      Location:25325
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07852
      Location:25364
      STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs
    5. XM_047421566.1XP_047277522.1  mitogen-activated protein kinase 15 isoform X4

    6. XM_011516927.3XP_011515229.1  mitogen-activated protein kinase 15 isoform X3

      See identical proteins and their annotated locations for XP_011515229.1

      Conserved Domains (2) summary
      smart00220
      Location:25306
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07852
      Location:25345
      STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs
    7. XM_011516928.3XP_011515230.1  mitogen-activated protein kinase 15 isoform X7

      See identical proteins and their annotated locations for XP_011515230.1

      Conserved Domains (2) summary
      smart00220
      Location:25325
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07852
      Location:25327
      STKc_MAPK15-like; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs

    RNA

    1. XR_001745494.2 RNA Sequence

    2. XR_001745493.2 RNA Sequence

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187571.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      193396..199505
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328750.1XP_054184725.1  mitogen-activated protein kinase 15 isoform X2

    2. XM_054328753.1XP_054184728.1  mitogen-activated protein kinase 15 isoform X5

    3. XM_054328754.1XP_054184729.1  mitogen-activated protein kinase 15 isoform X6

    4. XM_054328749.1XP_054184724.1  mitogen-activated protein kinase 15 isoform X1

    5. XM_054328752.1XP_054184727.1  mitogen-activated protein kinase 15 isoform X4

    6. XM_054328751.1XP_054184726.1  mitogen-activated protein kinase 15 isoform X3

    7. XM_054328755.1XP_054184730.1  mitogen-activated protein kinase 15 isoform X7

    RNA

    1. XR_008485613.1 RNA Sequence

    2. XR_008485612.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      144872787..144878895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360093.1XP_054216068.1  mitogen-activated protein kinase 15 isoform X2

    2. XM_054360096.1XP_054216071.1  mitogen-activated protein kinase 15 isoform X5

    3. XM_054360097.1XP_054216072.1  mitogen-activated protein kinase 15 isoform X6

    4. XM_054360092.1XP_054216067.1  mitogen-activated protein kinase 15 isoform X1

    5. XM_054360095.1XP_054216070.1  mitogen-activated protein kinase 15 isoform X4

    6. XM_054360094.1XP_054216069.1  mitogen-activated protein kinase 15 isoform X3

    7. XM_054360098.1XP_054216073.1  mitogen-activated protein kinase 15 isoform X7

    RNA

    1. XR_008487821.1 RNA Sequence

    2. XR_008487820.1 RNA Sequence