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    Cep120 centrosomal protein 120 [ Mus musculus (house mouse) ]

    Gene ID: 225523, updated on 8-Aug-2021

    Summary

    Official Symbol
    Cep120provided by MGI
    Official Full Name
    centrosomal protein 120provided by MGI
    Primary source
    MGI:MGI:2147298
    See related
    Ensembl:ENSMUSG00000048799
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccdc100; AU016693; A230075C01
    Expression
    Ubiquitous expression in testis adult (RPKM 17.4), cerebellum adult (RPKM 11.8) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Cep120 in Genome Data Viewer
    Location:
    18; 18 D1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (53814795..53877825, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (53681723..53745636, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (53841377..53904201, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41726 Neighboring gene PR domain containing 6 Neighboring gene predicted gene, 19466 Neighboring gene predicted gene, 41728 Neighboring gene casein kinase 1, gamma 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within astral microtubule organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in centrosome cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cerebral cortex development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in interkinetic nuclear migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within interkinetic nuclear migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of centriole elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of centriole elongation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of centrosome duplication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of microtubule-based process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    centrosomal protein of 120 kDa
    Names
    coiled-coil domain-containing protein 100

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178686.4NP_848801.2  centrosomal protein of 120 kDa

      See identical proteins and their annotated locations for NP_848801.2

      Status: VALIDATED

      Source sequence(s)
      AK038916, BC053439
      Consensus CDS
      CCDS37822.1
      UniProtKB/Swiss-Prot
      Q7TSG1
      Related
      ENSMUSP00000062433.7, ENSMUST00000049811.8
      Conserved Domains (5) summary
      cd00030
      Location:533566
      C2; C2 domain
      pfam08287
      Location:711791
      DASH_Spc19; Spc19
      pfam12416
      Location:118340
      DUF3668; Cep120 protein
      pfam17045
      Location:667920
      CEP63; Centrosomal protein of 63 kDa
      cl14603
      Location:9114
      C2; C2 domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      53814795..53877825 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161118.1XP_036017011.1  centrosomal protein of 120 kDa isoform X1

      Conserved Domains (3) summary
      pfam17380
      Location:646946
      DUF5401; Family of unknown function (DUF5401)
      pfam12416
      Location:118340
      DUF3668; Cep120 protein
      cl14603
      Location:9114
      C2; C2 domain
    2. XM_011246906.3XP_011245208.1  centrosomal protein of 120 kDa isoform X2

      Conserved Domains (3) summary
      COG1196
      Location:655866
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12416
      Location:118340
      DUF3668; Cep120 protein
      cl14603
      Location:9114
      C2; C2 domain
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