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    FGF8 fibroblast growth factor 8 [ Homo sapiens (human) ]

    Gene ID: 2253, updated on 27-Nov-2024

    Summary

    Official Symbol
    FGF8provided by HGNC
    Official Full Name
    fibroblast growth factor 8provided by HGNC
    Primary source
    HGNC:HGNC:3686
    See related
    Ensembl:ENSG00000107831 MIM:600483; AllianceGenome:HGNC:3686
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HH6; AIGF; KAL6; FGF-8; HBGF-8
    Summary
    The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FGF8 in Genome Data Viewer
    Location:
    10q24.32
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (101770109..101780369, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (102653607..102663864, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (103529866..103540126, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 3046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103483003-103483722 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:103489563-103490062 Neighboring gene uncharacterized LOC105378458 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103517739-103518240 Neighboring gene VISTA enhancer hs511 Neighboring gene uncharacterized LOC105378457 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103529890-103530667 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103534038-103534776 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103534777-103535515 Neighboring gene FGF8 5' regulatory region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103542131-103542770 Neighboring gene nucleophosmin/nucleoplasmin 3 Neighboring gene O-GlcNAcase Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103577734-103578309

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC149376

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chemoattractant activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables growth factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables type 1 fibroblast growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables type 1 fibroblast growth factor receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables type 2 fibroblast growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables type 2 fibroblast growth factor receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in anatomical structure morphogenesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in aorta morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in blood vessel remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in bone development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in branching involved in blood vessel morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in branching involved in salivary gland morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in branching involved in ureteric bud morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration involved in mesendoderm migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell proliferation in forebrain IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in corticotropin hormone secreting cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dopaminergic neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dopaminergic neuron differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in dorsal/ventral axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dorsal/ventral pattern formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in embryonic hindlimb morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic neurocranium morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epithelial to mesenchymal transition involved in endocardial cushion formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in fibroblast growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in forebrain dorsal/ventral pattern formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in forebrain morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in forebrain neuron development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gastrulation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in gonad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heart looping IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in larynx morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lung morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in male genitalia development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mesodermal cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mesonephros development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in metanephros development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in midbrain-hindbrain boundary development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in motor neuron axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cardiac muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neural plate morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuroepithelial cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in odontogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in organ growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in organ induction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in otic vesicle formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in outflow tract septum morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in pallium development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pharyngeal system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gene expression TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of mitotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of organ growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of stem cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of odontogenesis of dentin-containing tooth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction involved in regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in stem cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in subpallium development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in thyroid gland development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in thyroid-stimulating hormone-secreting cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    fibroblast growth factor 8
    Names
    androgen-induced growth factor
    fibroblast growth factor 8 (androgen-induced)
    heparin-binding growth factor 8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007151.1 RefSeqGene

      Range
      4957..10962
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001206389.2NP_001193318.1  fibroblast growth factor 8 isoform G

      See identical proteins and their annotated locations for NP_001193318.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (G) has an alternate 5' exon and lacks an internal segment in the 5' region, compared to variant F. The encoded isoform (G) is shorter at the N-terminus, compared to isoform F.
      Source sequence(s)
      AC010789, CN369230
      Consensus CDS
      CCDS73185.1
      UniProtKB/TrEMBL
      A0A087X1S5
      Related
      ENSP00000484420.1, ENST00000618991.5
      Conserved Domains (1) summary
      pfam00167
      Location:1100
      FGF; Fibroblast growth factor
    2. NM_006119.6NP_006110.1  fibroblast growth factor 8 isoform B precursor

      See identical proteins and their annotated locations for NP_006110.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (B) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (B) is shorter than isoform F.
      Source sequence(s)
      AC010789, BC128236, U36223
      Consensus CDS
      CCDS7515.1
      UniProtKB/TrEMBL
      A1A515
      Related
      ENSP00000321945.2, ENST00000347978.2
      Conserved Domains (1) summary
      pfam00167
      Location:52175
      FGF; Fibroblast growth factor
    3. NM_033163.5NP_149353.1  fibroblast growth factor 8 isoform F precursor

      See identical proteins and their annotated locations for NP_149353.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (F) encodes the longest isoform (F).
      Source sequence(s)
      AC010789, BC069106, BC128236
      Consensus CDS
      CCDS7516.1
      UniProtKB/TrEMBL
      A1A515
      Related
      ENSP00000321797.2, ENST00000320185.7
      Conserved Domains (1) summary
      pfam00167
      Location:81204
      FGF; Fibroblast growth factor
    4. NM_033164.4NP_149354.1  fibroblast growth factor 8 isoform E precursor

      See identical proteins and their annotated locations for NP_149354.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (E) uses an alternate splice site, compared to variant F. The encoded isoform (E) is shorter than isoform F.
      Source sequence(s)
      AC010789, BC128236, U46213
      Consensus CDS
      CCDS7517.1
      UniProtKB/Swiss-Prot
      A1A514, P55075, Q14915, Q15766
      UniProtKB/TrEMBL
      A1A515
      Related
      ENSP00000340039.3, ENST00000344255.8
      Conserved Domains (1) summary
      pfam00167
      Location:70193
      FGF; Fibroblast growth factor
    5. NM_033165.5NP_149355.1  fibroblast growth factor 8 isoform A precursor

      See identical proteins and their annotated locations for NP_149355.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (A) lacks an in-frame exon and uses an alternate splice site, compared to variant F. The encoded isoform (A) is shorter than isoform F.
      Source sequence(s)
      AC010789, BC128236
      Consensus CDS
      CCDS7518.1
      UniProtKB/TrEMBL
      A1A515
      Related
      ENSP00000344306.3, ENST00000346714.7
      Conserved Domains (1) summary
      pfam00167
      Location:41164
      FGF; Fibroblast growth factor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      101770109..101780369 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      102653607..102663864 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)