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    Fhod3 formin homology 2 domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 225288, updated on 19-Aug-2018

    Summary

    Official Symbol
    Fhod3provided by MGI
    Official Full Name
    formin homology 2 domain containing 3provided by MGI
    Primary source
    MGI:MGI:1925847
    See related
    Ensembl:ENSMUSG00000034295
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FHOS2; mKIAA1695; A930009H06Rik
    Expression
    Biased expression in heart adult (RPKM 21.5), bladder adult (RPKM 13.4) and 11 other tissues See more
    Orthologs

    Genomic context

    See Fhod3 in Genome Data Viewer
    Location:
    18; 18 A2
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (24708449..25133507)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (24867946..25292002)

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene elongator acetyltransferase complex subunit 2 Neighboring gene molybdenum cofactor sulfurase Neighboring gene expressed sequence AW554918 Neighboring gene tubulin polyglutamylase complex subunit 2 Neighboring gene predicted gene, 41678 Neighboring gene predicted gene, 32825 Neighboring gene CUGBP, Elav-like family member 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1695

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    actin filament network formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin filament organization IEA
    Inferred from Electronic Annotation
    more info
     
    cardiac myofibril assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sarcomere organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    sarcomere organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    sarcomere IDA
    Inferred from Direct Assay
    more info
    PubMed 
    striated muscle thin filament ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    FH1/FH2 domain-containing protein 3
    Names
    formin homolog overexpressed in spleen 2
    formin-family protein FHOS2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289654.1NP_001276583.1  FH1/FH2 domain-containing protein 3 isoform 2

      See identical proteins and their annotated locations for NP_001276583.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons in the coding region, compared to variant 1. This results in a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      AB078609, AK046161, BQ176384
      UniProtKB/Swiss-Prot
      Q76LL6
      Conserved Domains (1) summary
      pfam02181
      Location:8881259
      FH2; Formin Homology 2 Domain
    2. NM_001289655.1NP_001276584.1  FH1/FH2 domain-containing protein 3 isoform 3

      See identical proteins and their annotated locations for NP_001276584.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter isoform (3), compared to isoform 1.
      Source sequence(s)
      AB100088, AK046161, BQ176384
      UniProtKB/Swiss-Prot
      Q76LL6
      Conserved Domains (1) summary
      pfam02181
      Location:10071378
      FH2; Formin Homology 2 Domain
    3. NM_175276.4NP_780485.2  FH1/FH2 domain-containing protein 3 isoform 1

      See identical proteins and their annotated locations for NP_780485.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AB078608, AK046161, BQ176384
      Consensus CDS
      CCDS29104.1
      UniProtKB/Swiss-Prot
      Q76LL6
      Related
      ENSMUSP00000041361.7, ENSMUST00000037097.7
      Conserved Domains (1) summary
      pfam02181
      Location:10391410
      FH2; Formin Homology 2 Domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

      Range
      24708449..25133507
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525826.3XP_006525889.1  FH1/FH2 domain-containing protein 3 isoform X1

      Conserved Domains (1) summary
      pfam02181
      Location:10391410
      FH2; Formin Homology 2 Domain
    2. XM_006525830.3XP_006525893.1  FH1/FH2 domain-containing protein 3 isoform X3

      Conserved Domains (1) summary
      pfam02181
      Location:8531224
      FH2; Formin Homology 2 Domain
    3. XM_006525828.3XP_006525891.1  FH1/FH2 domain-containing protein 3 isoform X2

      Conserved Domains (1) summary
      pfam02181
      Location:8881259
      FH2; Formin Homology 2 Domain
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