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    Mib1 mindbomb E3 ubiquitin protein ligase 1 [ Mus musculus (house mouse) ]

    Gene ID: 225164, updated on 23-Jun-2021

    Summary

    Official Symbol
    Mib1provided by MGI
    Official Full Name
    mindbomb E3 ubiquitin protein ligase 1provided by MGI
    Primary source
    MGI:MGI:2443157
    See related
    Ensembl:ENSMUSG00000024294
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mi; Mib; DIP-1; E430019M12Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 12.8), frontal lobe adult (RPKM 9.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Mib1 in Genome Data Viewer
    Location:
    18; 18 A1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (10725523..10822969)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (10725625..10818578)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (10725623..10812215)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 3 Neighboring gene RIKEN cDNA 4930563E18 gene Neighboring gene predicted gene, 25116 Neighboring gene Mir133a-1, Mir1b and Mir1a-2 host gene Neighboring gene microRNA 133a-1 Neighboring gene microRNA 1a-2 Neighboring gene microRNA 1b Neighboring gene apurinic/apyrimidinic endonuclease 1 pseudogene Neighboring gene predicted gene, 35814 Neighboring gene PHD finger protein 14 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1323, MGC18948

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase MIB1
    Names
    DAPK-interacting protein-1
    RING-type E3 ubiquitin transferase MIB1
    mind bomb homolog 1
    mindbomb homolog 1
    skeletrophin
    NP_001351926.1
    NP_659109.2
    XP_006525874.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364997.1NP_001351926.1  E3 ubiquitin-protein ligase MIB1

      Status: VALIDATED

      Source sequence(s)
      AC105947, AC140316
      Consensus CDS
      CCDS29058.1
      Related
      ENSMUSP00000131712.2, ENSMUST00000165555.8
      Conserved Domains (9) summary
      PHA03095
      Location:439710
      PHA03095; ankyrin-like protein; Provisional
      cd02339
      Location:83127
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      sd00045
      Location:562593
      ANK; ANK repeat [structural motif]
      cd16724
      Location:818854
      RING1-HC_MIB1; RING finger 1, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
      cd16725
      Location:865901
      RING2-HC_MIB1; RING finger 2, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
      cd16727
      Location:9621003
      RING3-HC_MIB1; RING finger 3, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
      pfam06701
      Location:154218
      MIB_HERC2; Mib_herc2
      pfam12796
      Location:670770
      Ank_2; Ankyrin repeats (3 copies)
      pfam18346
      Location:333397
      SH3_15; Mind bomb SH3 repeat domain
    2. NM_144860.3NP_659109.2  E3 ubiquitin-protein ligase MIB1

      See identical proteins and their annotated locations for NP_659109.2

      Status: VALIDATED

      Source sequence(s)
      AC140316, AY245539
      Consensus CDS
      CCDS29058.1
      UniProtKB/Swiss-Prot
      Q80SY4
      Related
      ENSMUSP00000054428.5, ENSMUST00000052838.11
      Conserved Domains (9) summary
      PHA03095
      Location:439710
      PHA03095; ankyrin-like protein; Provisional
      cd02339
      Location:83127
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      sd00045
      Location:562593
      ANK; ANK repeat [structural motif]
      cd16724
      Location:818854
      RING1-HC_MIB1; RING finger 1, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
      cd16725
      Location:865901
      RING2-HC_MIB1; RING finger 2, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
      cd16727
      Location:9621003
      RING3-HC_MIB1; RING finger 3, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
      pfam06701
      Location:154218
      MIB_HERC2; Mib_herc2
      pfam12796
      Location:670770
      Ank_2; Ankyrin repeats (3 copies)
      pfam18346
      Location:333397
      SH3_15; Mind bomb SH3 repeat domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      10725523..10822969
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525811.5XP_006525874.1  E3 ubiquitin-protein ligase MIB1 isoform X1

      See identical proteins and their annotated locations for XP_006525874.1

      UniProtKB/Swiss-Prot
      Q80SY4
      Conserved Domains (9) summary
      PHA03095
      Location:439710
      PHA03095; ankyrin-like protein; Provisional
      cd02339
      Location:83127
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      sd00045
      Location:562593
      ANK; ANK repeat [structural motif]
      cd16724
      Location:818854
      RING1-HC_MIB1; RING finger 1, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
      cd16725
      Location:865901
      RING2-HC_MIB1; RING finger 2, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
      cd16727
      Location:9621003
      RING3-HC_MIB1; RING finger 3, HC subclass, found in mind bomb 1 (MIB1) and similar proteins
      pfam06701
      Location:154218
      MIB_HERC2; Mib_herc2
      pfam12796
      Location:670770
      Ank_2; Ankyrin repeats (3 copies)
      pfam18346
      Location:333397
      SH3_15; Mind bomb SH3 repeat domain

    RNA

    1. XR_004939841.1 RNA Sequence

    2. XR_004939840.1 RNA Sequence

    3. XR_004939842.1 RNA Sequence

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