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    Thoc1 THO complex 1 [ Mus musculus (house mouse) ]

    Gene ID: 225160, updated on 23-Jun-2021

    Summary

    Official Symbol
    Thoc1provided by MGI
    Official Full Name
    THO complex 1provided by MGI
    Primary source
    MGI:MGI:1919668
    See related
    Ensembl:ENSMUSG00000024287
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NMP-; NMP-84; AW107452; 3110002N20Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 14.3), CNS E18 (RPKM 13.3) and 19 other tissues See more
    Orthologs
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    Genomic context

    See Thoc1 in Genome Data Viewer
    Location:
    18; 18 A1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (9958180..9995484)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (9958180..9995484)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (9958178..9995482)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene cell division cycle associated 7 pseudogene Neighboring gene developmental pluripotency associated 4 pseudogene Neighboring gene ubiquitin specific peptidase 14 Neighboring gene Rho-associated coiled-coil containing protein kinase 1 Neighboring gene LSM6 homolog, U6 small nuclear RNA associated pseudogene Neighboring gene predicted gene, 26244

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC28284

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within apoptotic process RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA damage checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of isotype switching to IgA isotypes IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription, elongation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-templated transcription, elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription, elongation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of apoptotic process RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    involved_in replication fork processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in viral mRNA export from host cell nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of THO complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of THO complex part of transcription export complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of THO complex part of transcription export complex ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription export complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    THO complex subunit 1
    Names
    nuclear matrix protein p84
    tho1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153552.3NP_705780.1  THO complex subunit 1

      See identical proteins and their annotated locations for NP_705780.1

      Status: PROVISIONAL

      Source sequence(s)
      AK031785
      Consensus CDS
      CCDS37733.1
      UniProtKB/Swiss-Prot
      Q8R3N6
      Related
      ENSMUSP00000025137.8, ENSMUST00000025137.9
      Conserved Domains (2) summary
      cd08318
      Location:565650
      Death_NMPP84; Death domain of Nuclear Matrix Protein P84
      pfam11957
      Location:74539
      efThoc1; THO complex subunit 1 transcription elongation factor

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      9958180..9995484
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250419.1XP_030106279.1  THO complex subunit 1 isoform X1

      Conserved Domains (2) summary
      cd08318
      Location:427512
      Death_NMPP84; Death domain of Nuclear Matrix Protein P84
      pfam11957
      Location:1401
      efThoc1; THO complex subunit 1 transcription elongation factor
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