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    Wac WW domain containing adaptor with coiled-coil [ Mus musculus (house mouse) ]

    Gene ID: 225131, updated on 23-Oct-2018

    Summary

    Official Symbol
    Wacprovided by MGI
    Official Full Name
    WW domain containing adaptor with coiled-coilprovided by MGI
    Primary source
    MGI:MGI:2387357
    See related
    Ensembl:ENSMUSG00000024283 Vega:OTTMUSG00000036803
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wwp4; AI256735; AI256776; 1110067P07Rik; A230035H12Rik
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 13.8), CNS E14 (RPKM 12.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Wac in Genome Data Viewer
    Location:
    18; 18 A1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (7868832..7929028)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (7868856..7929025)

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene round spermatid basic protein 1-like pseudogene Neighboring gene high mobility group AT-hook I, related sequence 1 pseudogene Neighboring gene ribosomal protein S2 pseudogene Neighboring gene ribosomal protein S4, X-linked pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA polymerase II complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    G1 DNA damage checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    histone H2B conserved C-terminal lysine ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    histone monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of macroautophagy ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    WW domain-containing adapter protein with coiled-coil
    Names
    WW domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146298.2NP_001139770.1  WW domain-containing adapter protein with coiled-coil isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) is missing an internal coding exon compared to transcript variant 1. However, it maintains the same reading frame and encodes an isoform (2) which is 103 aa shorter than isoform 1.
      Source sequence(s)
      AC147624, AK079535, AK142196, AV585521, AW556980, BB737328, BC080851, BF461147, CA561963, CB524834, CJ054063, CO432980, DV042656
      Consensus CDS
      CCDS50218.1
      UniProtKB/Swiss-Prot
      Q924H7
      Related
      ENSMUSP00000089746.4, OTTMUSP00000052535, ENSMUST00000092112.10, OTTMUST00000094458
      Conserved Domains (2) summary
      pfam00397
      Location:133160
      WW; WW domain
      cl21494
      Location:320425
      Abhydrolase; alpha/beta hydrolases
    2. NM_001282093.1NP_001269022.1  WW domain-containing adapter protein with coiled-coil isoform 3

      See identical proteins and their annotated locations for NP_001269022.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' structure, and thus differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (3) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC130718, AC147624, AK079535, AK142196, AV585521, BB709347, BG083129, BM948716, BP766478, CB249484, CN668018, DV042656
      Consensus CDS
      CCDS70869.1
      UniProtKB/Swiss-Prot
      Q924H7
      Related
      ENSMUSP00000074454.4, OTTMUSP00000052529, ENSMUST00000074919.10, OTTMUST00000094452
      Conserved Domains (2) summary
      pfam00397
      Location:88115
      WW; WW domain
      cl26464
      Location:172483
      Atrophin-1; Atrophin-1 family
    3. NM_001360956.1NP_001347885.1  WW domain-containing adapter protein with coiled-coil isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4z) uses an alternate 5' structure, and thus differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (3) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC130718, AC147624
      Conserved Domains (2) summary
      pfam00397
      Location:88115
      WW; WW domain
      cl26464
      Location:172483
      Atrophin-1; Atrophin-1 family
    4. NM_153085.4NP_694725.3  WW domain-containing adapter protein with coiled-coil isoform 1

      See identical proteins and their annotated locations for NP_694725.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC147624, AK079535, AK142196, AV585521, AW556980, BB737328, BC080851, CB524834, CJ054063, DV042656
      Consensus CDS
      CCDS29046.1
      UniProtKB/Swiss-Prot
      Q924H7
      Related
      ENSMUSP00000132117.1, OTTMUSP00000052531, ENSMUST00000167020.7, OTTMUST00000094454
      Conserved Domains (2) summary
      pfam00397
      Location:133160
      WW; WW domain
      cl21494
      Location:423528
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

      Range
      7868832..7929028
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246888.2XP_011245190.1  WW domain-containing adapter protein with coiled-coil isoform X3

      See identical proteins and their annotated locations for XP_011245190.1

      UniProtKB/Swiss-Prot
      Q924H7
      Conserved Domains (2) summary
      pfam00397
      Location:88115
      WW; WW domain
      cl26464
      Location:172483
      Atrophin-1; Atrophin-1 family
    2. XM_006525803.3XP_006525866.1  WW domain-containing adapter protein with coiled-coil isoform X1

      Conserved Domains (2) summary
      pfam00397
      Location:139166
      WW; WW domain
      cl21494
      Location:429534
      Abhydrolase; alpha/beta hydrolases
    3. XM_006525804.3XP_006525867.1  WW domain-containing adapter protein with coiled-coil isoform X2

      Conserved Domains (2) summary
      pfam00397
      Location:139166
      WW; WW domain
      cl21494
      Location:426531
      Abhydrolase; alpha/beta hydrolases
    4. XM_006525806.3XP_006525869.1  WW domain-containing adapter protein with coiled-coil isoform X4

      Conserved Domains (2) summary
      pfam00397
      Location:139166
      WW; WW domain
      cl21494
      Location:326431
      Abhydrolase; alpha/beta hydrolases
    5. XM_006525807.3XP_006525870.1  WW domain-containing adapter protein with coiled-coil isoform X5

      Conserved Domains (2) summary
      pfam00397
      Location:139166
      WW; WW domain
      cl21494
      Location:323428
      Abhydrolase; alpha/beta hydrolases
    6. XM_017317866.1XP_017173355.1  WW domain-containing adapter protein with coiled-coil isoform X6

      Related
      ENSMUSP00000133185.1, OTTMUSP00000052530, ENSMUST00000171042.7, OTTMUST00000094453
      Conserved Domains (2) summary
      pfam00397
      Location:88115
      WW; WW domain
      cl21494
      Location:275380
      Abhydrolase; alpha/beta hydrolases
    7. XM_006525805.2XP_006525868.1  WW domain-containing adapter protein with coiled-coil isoform X3

      UniProtKB/Swiss-Prot
      Q924H7
      Related
      ENSMUSP00000128321.1, OTTMUSP00000052532, ENSMUST00000172018.7, OTTMUST00000094455
      Conserved Domains (2) summary
      pfam00397
      Location:88115
      WW; WW domain
      cl26464
      Location:172483
      Atrophin-1; Atrophin-1 family
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