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    Fbxo11 F-box protein 11 [ Mus musculus (house mouse) ]

    Gene ID: 225055, updated on 23-Jun-2021

    Summary

    Official Symbol
    Fbxo11provided by MGI
    Official Full Name
    F-box protein 11provided by MGI
    Primary source
    MGI:MGI:2147134
    See related
    Ensembl:ENSMUSG00000005371
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Jf; C80048
    Expression
    Ubiquitous expression in CNS E14 (RPKM 23.5), whole brain E14.5 (RPKM 20.3) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Fbxo11 in Genome Data Viewer
    Location:
    17 E4; 17 57.87 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (88298287..88373473, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (87990859..88066045, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (88390199..88464625, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41649 Neighboring gene ribosomal protein L36, pseudogene 4 Neighboring gene mutS homolog 6 Neighboring gene predicted gene 4832 Neighboring gene predicted gene, 31499

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Chemically induced (ENU) (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC156416

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-arginine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cellular protein modification process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081034.3NP_001074503.1  F-box only protein 11 isoform 1

      See identical proteins and their annotated locations for NP_001074503.1

      Status: VALIDATED

      Source sequence(s)
      AC087233, AC154673, AI853268, BC055343, BY127063, CA557033, CA749247, CF169182, CF172333, CN533292, CN666984
      Consensus CDS
      CCDS37717.1
      UniProtKB/Swiss-Prot
      Q7TPD1
      Related
      ENSMUSP00000005504.9, ENSMUST00000005504.15
      Conserved Domains (3) summary
      pfam12937
      Location:160203
      F-box-like; F-box-like
      pfam13229
      Location:667812
      Beta_helix; Right handed beta helix region
      cl19744
      Location:853894
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
    2. NM_001348248.1NP_001335177.1  F-box only protein 11 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC087233, AC154673, BC055343, BY127063, CA557033, CA749247, CF169182, CF172333, CN533292, CN666984
      UniProtKB/Swiss-Prot
      Q7TPD1
      Conserved Domains (3) summary
      pfam12937
      Location:73116
      F-box-like
      pfam13229
      Location:580739
      Beta_helix; Right handed beta helix region
      cl19744
      Location:766807
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
    3. NM_001379303.1NP_001366232.1  F-box only protein 11 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC087233, AC154673
      Conserved Domains (3) summary
      pfam12937
      Location:159202
      F-box-like
      pfam13229
      Location:666825
      Beta_helix; Right handed beta helix region
      cl19744
      Location:852893
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
    4. NM_001379304.1NP_001366233.1  F-box only protein 11 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC087233, AC154673
      Conserved Domains (3) summary
      pfam12937
      Location:73116
      F-box-like
      pfam13229
      Location:580739
      Beta_helix; Right handed beta helix region
      cl19744
      Location:766807
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
    5. NM_001379305.1NP_001366234.1  F-box only protein 11 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC087233, AC154673
      Conserved Domains (3) summary
      pfam12937
      Location:72115
      F-box-like
      pfam13229
      Location:579738
      Beta_helix; Right handed beta helix region
      cl19744
      Location:765806
      zf-UBR; Putative zinc finger in N-recognin (UBR box)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      88298287..88373473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160579.1XP_036016472.1  F-box only protein 11 isoform X1

      Related
      ENSMUSP00000121206.3, ENSMUST00000130379.9
      Conserved Domains (3) summary
      pfam12937
      Location:72115
      F-box-like
      pfam13229
      Location:579738
      Beta_helix; Right handed beta helix region
      cl19744
      Location:765806
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
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