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    Fez2 fasciculation and elongation protein zeta 2 (zygin II) [ Mus musculus (house mouse) ]

    Gene ID: 225020, updated on 31-Jan-2019

    Summary

    Official Symbol
    Fez2provided by MGI
    Official Full Name
    fasciculation and elongation protein zeta 2 (zygin II)provided by MGI
    Primary source
    MGI:MGI:2675856
    See related
    Ensembl:ENSMUSG00000056121
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9030616F16; D17Ertd315e
    Expression
    Ubiquitous expression in bladder adult (RPKM 18.4), cerebellum adult (RPKM 9.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Fez2 in Genome Data Viewer
    Location:
    17 E2; 17 48.57 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (78369212..78418152, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (78777225..78817443, complement)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 32282 Neighboring gene cysteine rich transmembrane BMP regulator 1 (chordin like) Neighboring gene predicted gene, 41620 Neighboring gene predicted gene, 32336 Neighboring gene 60S ribosomal protein L39 pseudogene Neighboring gene predicted gene, 32464 Neighboring gene histone deacetylase 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    negative regulation of autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    fasciculation and elongation protein zeta-2
    Names
    zygin 2
    zygin II

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285940.1NP_001272869.1  fasciculation and elongation protein zeta-2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC103598, AC151270
      Consensus CDS
      CCDS70844.1
      UniProtKB/TrEMBL
      D3Z6D5
      Related
      ENSMUSP00000108106.1, ENSMUST00000112487.2
      Conserved Domains (1) summary
      pfam07763
      Location:42265
      FEZ; FEZ-like protein
    2. NM_001285946.1NP_001272875.1  fasciculation and elongation protein zeta-2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 3) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC103598, AC151270
      Related
      ENSMUSP00000157359.1, ENSMUST00000234029.1
      Conserved Domains (1) summary
      pfam07763
      Location:42265
      FEZ; FEZ-like protein
    3. NM_001285949.1NP_001272878.1  fasciculation and elongation protein zeta-2 isoform 4

      See identical proteins and their annotated locations for NP_001272878.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR and has multiple coding region differences including the use of an alternate 3' terminal exon. The resulting protein (isoform 4) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC103598, AC151270
      UniProtKB/TrEMBL
      Q3TN06
      Related
      ENSMUSP00000157187.1, ENSMUST00000234052.1
      Conserved Domains (1) summary
      pfam07763
      Location:42265
      FEZ; FEZ-like protein
    4. NM_001360407.1NP_001347336.1  fasciculation and elongation protein zeta-2 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting protein (isoform 5) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC103598, AC151270
      Conserved Domains (1) summary
      pfam07763
      Location:42265
      FEZ; FEZ-like protein
    5. NM_199448.3NP_955519.1  fasciculation and elongation protein zeta-2 isoform 2

      See identical proteins and their annotated locations for NP_955519.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region compared to vatiant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC103598, AC151270, AK150241
      Consensus CDS
      CCDS28977.1
      UniProtKB/Swiss-Prot
      Q6TYB5
      UniProtKB/TrEMBL
      Q3U049
      Related
      ENSMUSP00000068987.7, ENSMUST00000070039.13
      Conserved Domains (1) summary
      pfam07763
      Location:42265
      FEZ; FEZ-like protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      78369212..78418152 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524189.3XP_006524252.1  fasciculation and elongation protein zeta-2 isoform X1

      Related
      ENSMUSP00000157338.1, ENSMUST00000234530.1
      Conserved Domains (1) summary
      pfam07763
      Location:42265
      FEZ; FEZ-like protein
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