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    Crb3 crumbs family member 3 [ Mus musculus (house mouse) ]

    Gene ID: 224912, updated on 31-Jan-2019

    Summary

    Official Symbol
    Crb3provided by MGI
    Official Full Name
    crumbs family member 3provided by MGI
    Primary source
    MGI:MGI:2670904
    See related
    Ensembl:ENSMUSG00000044279
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AU015179; AU041752; 5730439B18
    Expression
    Broad expression in duodenum adult (RPKM 28.1), colon adult (RPKM 24.9) and 17 other tissues See more
    Orthologs

    Genomic context

    See Crb3 in Genome Data Viewer
    Location:
    17; 17 D
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (57061627..57068117)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (57201700..57205341)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene KH-type splicing regulatory protein Neighboring gene solute carrier family 25, member 41 Neighboring gene solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 Neighboring gene DENN/MADD domain containing 1C Neighboring gene tubulin, beta 4A class IVA Neighboring gene predicted gene 11110 Neighboring gene predicted gene, 46589

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    cell-cell junction organization ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    establishment of epithelial cell apical/basal polarity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    Component Evidence Code Pubs
    apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical plasma membrane ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347408.1NP_001334337.1  protein crumbs homolog 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      BP769883, CT571247
      Consensus CDS
      CCDS84327.1
      UniProtKB/Swiss-Prot
      Q8QZT4
      Conserved Domains (1) summary
      pfam15345
      Location:2109
      TMEM51; Transmembrane protein 51
    2. NM_001359813.1NP_001346742.1  protein crumbs homolog 3 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AK077528, AK167279, BP769883
    3. NM_001359814.1NP_001346743.1  protein crumbs homolog 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT571247
      Conserved Domains (1) summary
      pfam15345
      Location:2109
      TMEM51; Transmembrane protein 51
    4. NM_177638.5NP_808306.1  protein crumbs homolog 3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_808306.1

      Status: VALIDATED

      Source sequence(s)
      CT571247
      Consensus CDS
      CCDS28924.1
      UniProtKB/Swiss-Prot
      Q8QZT4
      Related
      ENSMUSP00000094902.3, ENSMUST00000097299.9

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      57061627..57068117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524167.3XP_006524230.1  protein crumbs homolog 3 isoform X2

      UniProtKB/Swiss-Prot
      Q8QZT4
      Conserved Domains (1) summary
      pfam14610
      Location:2277
      DUF4448; Protein of unknown function (DUF4448)
    2. XM_006524165.3XP_006524228.1  protein crumbs homolog 3 isoform X1

      UniProtKB/Swiss-Prot
      Q8QZT4
      Conserved Domains (1) summary
      pfam15345
      Location:2109
      TMEM51; Transmembrane protein 51
    3. XM_006524164.1XP_006524227.1  protein crumbs homolog 3 isoform X1

      Related
      ENSMUSP00000125760.1, ENSMUST00000169543.7
      Conserved Domains (1) summary
      pfam15345
      Location:2109
      TMEM51; Transmembrane protein 51
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