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    Abcf1 ATP-binding cassette, sub-family F member 1 [ Mus musculus (house mouse) ]

    Gene ID: 224742, updated on 2-Nov-2024

    Summary

    Official Symbol
    Abcf1provided by MGI
    Official Full Name
    ATP-binding cassette, sub-family F member 1provided by MGI
    Primary source
    MGI:MGI:1351658
    See related
    Ensembl:ENSMUSG00000038762 AllianceGenome:MGI:1351658
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Abc50; GCN20; D17Wsu166e
    Summary
    Predicted to enable ATP binding activity; ribosome binding activity; and translation activator activity. Predicted to be involved in positive regulation of translation and translational initiation. Predicted to be located in cytosol; nucleus; and ribosome. Is expressed in several structures, including eye; genitourinary system; hemolymphoid system; lung; and nervous system. Orthologous to human ABCF1 (ATP binding cassette subfamily F member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 41.9), CNS E11.5 (RPKM 33.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Abcf1 in Genome Data Viewer
    Location:
    17 B1; 17 18.8 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (36267711..36280642, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35956819..35969750, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42482 Neighboring gene STARR-positive B cell enhancer ABC_E11644 Neighboring gene ring-box 1, pseudogene Neighboring gene STARR-seq mESC enhancer starr_42484 Neighboring gene protein phosphatase 1, regulatory subunit 10 pseudogene Neighboring gene microRNA 877 Neighboring gene STARR-positive B cell enhancer ABC_E8674 Neighboring gene predicted gene, 32655 Neighboring gene proline-rich polypeptide 3 Neighboring gene guanine nucleotide binding protein-like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ribosome binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribosome binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables translation activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables translation activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT involved_in ribosome biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in ribosome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ATP-binding cassette sub-family F member 1
    Names
    ATP-binding cassette, sub-family F (GCN20), member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013854.1NP_038882.1  ATP-binding cassette sub-family F member 1

      See identical proteins and their annotated locations for NP_038882.1

      Status: VALIDATED

      Source sequence(s)
      BC063094
      Consensus CDS
      CCDS28713.1
      UniProtKB/Swiss-Prot
      Q6NV71, Q6P542
      UniProtKB/TrEMBL
      Q5RL55
      Related
      ENSMUSP00000036881.9, ENSMUST00000043757.15
      Conserved Domains (2) summary
      cd03221
      Location:296517
      ABCF_EF-3; ATP-binding cassette domain of elongation factor 3, subfamily F
      COG0488
      Location:294825
      Uup; ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      36267711..36280642 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)