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    Lsg1 large 60S subunit nuclear export GTPase 1 [ Mus musculus (house mouse) ]

    Gene ID: 224092, updated on 19-Mar-2019

    Summary

    Official Symbol
    Lsg1provided by MGI
    Official Full Name
    large 60S subunit nuclear export GTPase 1provided by MGI
    Primary source
    MGI:MGI:107236
    See related
    Ensembl:ENSMUSG00000022538
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AA409273; 5830465I20; D16Bwg1547e
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 13.9), limb E14.5 (RPKM 8.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Lsg1 in Genome Data Viewer
    Location:
    16 B2; 16 21.34 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (30561369..30587613, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (30561455..30587675, complement)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene ATPase type 13A3 Neighboring gene transmembrane protein 44 Neighboring gene family with sequence similarity 43, member A Neighboring gene predicted gene, 33502

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from BioSystems

    • Ribosome biogenesis in eukaryotes, organism-specific biosystem (from KEGG)
      Ribosome biogenesis in eukaryotes, organism-specific biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
    • Ribosome biogenesis in eukaryotes, conserved biosystem (from KEGG)
      Ribosome biogenesis in eukaryotes, conserved biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
    • cyclic AMP biosynthesis, organism-specific biosystem (from BIOCYC)
      cyclic AMP biosynthesis, organism-specific biosystemCyclic adenosine monophosphate (cAMP, cyclic AMP or 3'-5'-cyclic adenosine monophosphate) is a secondary messenger that is important in many biological processes. cAMP is derived from adenosine triph...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    nuclear export ISO
    Inferred from Sequence Orthology
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Cajal body ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    large subunit GTPase 1 homolog
    NP_835170.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178069.5NP_835170.1  large subunit GTPase 1 homolog

      See identical proteins and their annotated locations for NP_835170.1

      Status: PROVISIONAL

      Source sequence(s)
      BC043724
      Consensus CDS
      CCDS37311.1
      UniProtKB/Swiss-Prot
      Q3UM18
      Related
      ENSMUSP00000112860.2, ENSMUST00000117363.8
      Conserved Domains (2) summary
      cd01857
      Location:163430
      HSR1_MMR1; A circularly permuted subfamily of the Ras GTPases
      COG1161
      Location:151540
      RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      30561369..30587613 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001781813.1 RNA Sequence

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