U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Eif2b5 eukaryotic translation initiation factor 2B, subunit 5 epsilon [ Mus musculus (house mouse) ]

    Gene ID: 224045, updated on 27-Nov-2024

    Summary

    Official Symbol
    Eif2b5provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 2B, subunit 5 epsilonprovided by MGI
    Primary source
    MGI:MGI:2446176
    See related
    Ensembl:ENSMUSG00000003235 AllianceGenome:MGI:2446176
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity; translation initiation factor activity; and translation initiation factor binding activity. Predicted to be involved in several processes, including T cell receptor signaling pathway; glial cell development; and positive regulation of translational initiation. Located in cytoplasm and nucleus. Is expressed in central nervous system and retina. Used to study leukoencephalopathy with vanishing white matter. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter and leukoencephalopathy with vanishing white matter 5. Orthologous to human EIF2B5 (eukaryotic translation initiation factor 2B subunit epsilon). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 21.4), placenta adult (RPKM 18.0) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Eif2b5 in Genome Data Viewer
    Location:
    16 A3; 16 12.45 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (20317544..20328073)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (20498795..20509325)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family C member 5 Neighboring gene STARR-seq mESC enhancer starr_40320 Neighboring gene STARR-seq mESC enhancer starr_40322 Neighboring gene STARR-seq mESC enhancer starr_40323 Neighboring gene predicted gene, 41432 Neighboring gene STARR-seq mESC enhancer starr_40326 Neighboring gene STARR-seq mESC enhancer starr_40327 Neighboring gene STARR-seq mESC enhancer starr_40328 Neighboring gene predicted gene, 16618 Neighboring gene STARR-positive B cell enhancer ABC_E1488 Neighboring gene dishevelled segment polarity protein 3 Neighboring gene adaptor-related protein complex 2, mu 1 subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables translation initiation factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables translation initiation factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables translation initiation factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in T cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in astrocyte development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in astrocyte development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in astrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in astrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cytoplasmic translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytoplasmic translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in hippocampus development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in myelination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in myelination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in oligodendrocyte development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oligodendrocyte development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ovarian follicle development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to endoplasmic reticulum stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to glucose ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to glucose ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to heat ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to peptide hormone ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to peptide hormone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of eukaryotic translation initiation factor 2B complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of eukaryotic translation initiation factor 2B complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of eukaryotic translation initiation factor 2B complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    translation initiation factor eIF2B subunit epsilon
    Names
    eIF-2B GDP-GTP exchange factor subunit epsilon
    eIF2B GDP-GTP exchange factor subunit epsilon
    translation initiation factor eIF-2B subunit epsilon

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417002.1NP_001403931.1  translation initiation factor eIF2B subunit epsilon isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC161756
    2. NM_001417003.1NP_001403932.1  translation initiation factor eIF2B subunit epsilon isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC161756
    3. NM_001417004.1NP_001403933.1  translation initiation factor eIF2B subunit epsilon isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC161756
    4. NM_001417005.1NP_001403934.1  translation initiation factor eIF2B subunit epsilon isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC161756
    5. NM_172265.3NP_758469.1  translation initiation factor eIF2B subunit epsilon isoform 1

      See identical proteins and their annotated locations for NP_758469.1

      Status: VALIDATED

      Source sequence(s)
      AC161756
      Consensus CDS
      CCDS28047.1
      UniProtKB/Swiss-Prot
      Q3TU39, Q8CHW4
      Related
      ENSMUSP00000003320.7, ENSMUST00000003320.14
      Conserved Domains (4) summary
      cd05787
      Location:357435
      LbH_eIF2B_epsilon; eIF-2B epsilon subunit, central Left-handed parallel beta-Helix (LbH) domain: eIF-2B is a eukaryotic translation initiator, a guanine nucleotide exchange factor (GEF) composed of five different subunits (alpha, beta, gamma, delta and epsilon). eIF2B is ...
      cd04197
      Location:39253
      eIF-2B_epsilon_N; The N-terminal domain of epsilon subunit of the eIF-2B is a subfamily of glycosyltransferase 2
      cd11558
      Location:544707
      W2_eIF2B_epsilon; C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon
      COG1044
      Location:296406
      LpxD; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [Cell wall/membrane/envelope biogenesis]

    RNA

    1. NR_184408.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC161756
    2. NR_184409.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC161756
    3. NR_184410.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC161756

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      20317544..20328073
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004939183.1 RNA Sequence