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    Eif2b5 eukaryotic translation initiation factor 2B, subunit 5 epsilon [ Mus musculus (house mouse) ]

    Gene ID: 224045, updated on 23-Jun-2021

    Summary

    Official Symbol
    Eif2b5provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 2B, subunit 5 epsilonprovided by MGI
    Primary source
    MGI:MGI:2446176
    See related
    Ensembl:ENSMUSG00000003235
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C81315
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 21.4), placenta adult (RPKM 18.0) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Eif2b5 in Genome Data Viewer
    Location:
    16; 16 A3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (20317544..20328075)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (20498795..20509325)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (20498890..20509398)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family C (CFTR/MRP), member 5 Neighboring gene predicted gene, 41432 Neighboring gene predicted gene, 16618 Neighboring gene dishevelled segment polarity protein 3 Neighboring gene adaptor-related protein complex 2, mu 1 subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables translation initiation factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables translation initiation factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in aging ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in astrocyte development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in astrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in myelination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oligodendrocyte development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to glucose ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to peptide hormone ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of eukaryotic translation initiation factor 2B complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of eukaryotic translation initiation factor 2B complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    translation initiation factor eIF-2B subunit epsilon
    Names
    eIF-2B GDP-GTP exchange factor subunit epsilon

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172265.2NP_758469.1  translation initiation factor eIF-2B subunit epsilon

      See identical proteins and their annotated locations for NP_758469.1

      Status: VALIDATED

      Source sequence(s)
      AC161756, AK160985
      Consensus CDS
      CCDS28047.1
      UniProtKB/Swiss-Prot
      Q8CHW4
      Related
      ENSMUSP00000003320.7, ENSMUST00000003320.14
      Conserved Domains (4) summary
      cd05787
      Location:357435
      LbH_eIF2B_epsilon; eIF-2B epsilon subunit, central Left-handed parallel beta-Helix (LbH) domain: eIF-2B is a eukaryotic translation initiator, a guanine nucleotide exchange factor (GEF) composed of five different subunits (alpha, beta, gamma, delta and epsilon). eIF2B is ...
      cd04197
      Location:39253
      eIF-2B_epsilon_N; The N-terminal domain of epsilon subunit of the eIF-2B is a subfamily of glycosyltransferase 2
      cd11558
      Location:544707
      W2_eIF2B_epsilon; C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon
      COG1208
      Location:38434
      GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      20317544..20328075
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004939183.1 RNA Sequence

    2. XR_384555.5 RNA Sequence

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