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    Klhl22 kelch-like 22 [ Mus musculus (house mouse) ]

    Gene ID: 224023, updated on 31-Jan-2019

    Summary

    Official Symbol
    Klhl22provided by MGI
    Official Full Name
    kelch-like 22provided by MGI
    Primary source
    MGI:MGI:1337995
    See related
    Ensembl:ENSMUSG00000022750
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kelchl; 2610318I18Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 28.6), ovary adult (RPKM 22.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Klhl22 in Genome Data Viewer
    Location:
    16 A3; 16 11.01 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (17759089..17793382)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (17759714..17793475)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein 1 light chain 3 pseudogene copy 8 Neighboring gene biorientation of chromosomes in cell division protein 1 pseudogene Neighboring gene scavenger receptor class F, member 2 Neighboring gene zinc finger protein 520, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to amino acid stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to leucine ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic sister chromatid segregation ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic spindle assembly checkpoint IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic spindle assembly checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein monoubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    polar microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    polar microtubule ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359068.1NP_001345997.1  kelch-like protein 22

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC087802
      Conserved Domains (2) summary
      sd00038
      Location:340385
      Kelch; KELCH repeat [structural motif]
      cl28614
      Location:52592
      BTB; Broad-Complex, Tramtrack and Bric a brac
    2. NM_145479.4NP_663454.3  kelch-like protein 22

      See identical proteins and their annotated locations for NP_663454.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI845204, AK143514, CJ159851
      Consensus CDS
      CCDS49783.1
      UniProtKB/Swiss-Prot
      Q99JN2
      Related
      ENSMUSP00000127227.1, ENSMUST00000165790.8
      Conserved Domains (2) summary
      sd00038
      Location:340385
      Kelch; KELCH repeat [structural motif]
      cl28614
      Location:52592
      BTB; Broad-Complex, Tramtrack and Bric a brac

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      17759089..17793382
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522041.3XP_006522104.1  kelch-like protein 22 isoform X2

      See identical proteins and their annotated locations for XP_006522104.1

      UniProtKB/Swiss-Prot
      Q99JN2
      Conserved Domains (2) summary
      sd00038
      Location:340385
      Kelch; KELCH repeat [structural motif]
      cl28614
      Location:52592
      BTB; Broad-Complex, Tramtrack and Bric a brac
    2. XM_006522040.3XP_006522103.1  kelch-like protein 22 isoform X2

      UniProtKB/Swiss-Prot
      Q99JN2
      Conserved Domains (2) summary
      sd00038
      Location:340385
      Kelch; KELCH repeat [structural motif]
      cl28614
      Location:52592
      BTB; Broad-Complex, Tramtrack and Bric a brac
    3. XM_006522039.2XP_006522102.1  kelch-like protein 22 isoform X1

      See identical proteins and their annotated locations for XP_006522102.1

      Conserved Domains (6) summary
      smart00612
      Location:564610
      Kelch; Kelch domain
      smart00875
      Location:172275
      BACK; BTB And C-terminal Kelch
      PHA03098
      Location:71611
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:359404
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:64162
      BTB; BTB/POZ domain
      pfam01344
      Location:409452
      Kelch_1; Kelch motif

    Reference GRCm38.p4 129S1/SvImJ

    Genomic

    1. NT_187007.1 Reference GRCm38.p4 129S1/SvImJ

      Range
      17127..50889
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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